Pharmechanics
@Pharmechanic
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Pharmacology data analyst
Binghamton, NY
Joined October 2018
In the mood for a deep dive on binding kinetics in drug discovery? Check out our new YouTube video: https://t.co/rWCGe1lrxi Topics include: Binding kinetics & pharmacodynamics In vitro potency distortion by slow dissociation Real-world case study on kinetics in drug discovery
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A game-changing approach for multi receptor profiling from Montana Molecular! Check out this short video.
A real world example in drug discovery: Researchers are using BacMam to get compound profiling results on multiple receptors at a fraction of the time and cost. Here's how it works: https://t.co/U3HevbU2GH
#DrugDiscovery #gpcr
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Looking for support with drug discovery pharmacology? Check out this short video on my consulting services, illustrated by CRF receptor drug discovery: https://t.co/rGZ29oWw0V Please get in touch (sam.hoare@pharmechanics.com) and check out my website at
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This is going to be awesome!
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⚠️Registration Deadline today! Register for Principles of Pharmacology II - Advanced Methods for the Optimization of Candidate Selection with Dr. Kenakin. Learn more about new ligands and new GPCR behaviors that produce unique drug profiles. ✳️ https://t.co/GZivmtRkNj
#gpcr
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We are hiring! A postdoc position is immediately available in the Orlandi lab in the Department of Pharmacology and Physiology at the University of Rochester, NY. Join us to study orphan GPCRs! Please RT
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Here's why we like BacMam as a vector for receptors and our sensors:🧵 ▫️ Expression in Many Cell Types and Primary Cultures ▫️ BSL-1 with Simple Workflow ▫️ Large Payload ~34kb ▫️ Consistent Controlled Titratable Expression Levels ▫️ Long Shelf Life https://t.co/Vl1EC4arSc
montanamolecular.com
Explore the benefits of the BacMam expression system, why we prefer it over plasmid transfection, and why we use it to deliver our sensors.
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Dr. Terry Kenakin will soon start the course Principles of Pharmacology II - Advanced Methods for the Optimization of Candidate Selection 📖 Are you joining this 5-lecture series? ✳️Register today at https://t.co/GZivmtRkNj
#gpcr #drgpcr
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Visualization of membrane localization and the functional state of CB2R pools using matched agonist and inverse agonist probe pairs - now published in Chemical Science
pubs.rsc.org
The diversity of physiological roles of the endocannabinoid system has turned it into an attractive yet elusive therapeutic target. However, chemical probes with various functionalities could pave...
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The conclusion of an exceptional meeting on "Emergence of irreversible modulation in drug discovery". I would like to thank everyone for contributing to the success of this meeting. Image credit and Copyright: @BritPharmSoc
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Thanks to @wegisdezon from @ScienceLinX, I could play with one of the microscopes that will be on #microscopiedag exhibitions in Groningen on Nov 9th It turned out to be much more fun than I could imagine! 🔬😍 In this thread, I will post microscopy images and movies 🧵1/n
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👇Read on to find out about a fascinating #GPCR acting as a domain of a larger transmembrane protein at the lysosome, important for regulation of #mTOR A wonderful collaboration with @Dr_Ellisdon between @MIPS_DDB @MIPS_Australia and @MonashBDI, and a huge effort from our teams
We are thrilled beyond words to see our LYCHOS (GPR155) publication out today in @Nature. 🥳 “LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR” https://t.co/I7ibRphMzS 🧵
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Excited to share new work from our lab led by Uyen Pham – “Location-biased β-arrestin conformations direct GPCR signaling.” We demonstrate that b-arrestins display distinct conformations in different subcellular locations in regulating ERK MAP kinases.
biorxiv.org
β-arrestins are multifunctional intracellular proteins that regulate the desensitization, internalization and signaling of over 800 different G protein-coupled receptors (GPCRs) and interact with a...
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Pick a course and learn today! Don’t miss the opportunity to expand your pharmacology knowledge with Dr. Terry Kenakin or Dr. Sam Hoare's course, now On-Demand for Ecosystem Premium Members! ❇️Go to https://t.co/iPmitgTyGr
#gpcr #drgpcr
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I am serving as a guest editor with @jjanetzko for a special issue in ASPET's Molecular Pharmacology journal called "Emerging Voices in GPCR Biology". This issue will celebrate top-tier research showcased by attendees of the 4th Transatlantic ECI GPCR Symposium. 1/4
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Thinking about a postdoc next year? Love the outdoors and doing cool science? ⛰️ 🚴 ⛷️ ☀️ 🧪 👩🏻🔬 👨🏼🔬 We’d love to meet with people interested in chemical/structural biology, protein dynamics and membrane proteins esp GPCRs 😉 DM or email w questions!
🧑🔬Are you thinking of doing a PostDoc? We would LOVE to “CU” here!🎉 Come to PEAKS, our Postdoc Recruitment event taking place April 7-8, 2025! 🧪 Present your Thesis work 🧑🏫 Meet our Faculty 🏫 Campus Tours 🤝 Networking Opportunities 💬 Engage with the CU Anschutz Community
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Fascinating! Thanks for posting on DISCo-BRET!
Introducing DISCo-BRET!🪩🕺 Check out our new pre-print in collaboration with Elisabeth Rexen Ulven’s group @UCPH_Research describing new technique to measure simultaneous ligand binding to the same #GPCR
https://t.co/yJPrsRTgIi
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Join a dynamic pharmacology class with Dr. Terry Kenakin! 🙌 Register before August 31st for these courses to deepen your knowledge of pharmacologic techniques required to create a GPCR Target Program aimed at the discovery of new drugs 🚀 ❇️ https://t.co/jJEI5l8wOk
#gpcr #drgpcr
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Inspired by the teaching of Drs. Terry Kenakin, David Hall, Arthur Christopoulos, and many other dedicated drug discovery scientists. Thanks to @yaminaberchiche & the @DrGPCR Ecosystem for the encouragement, and Dr Thomas Hughes of @livecellassays for asking the questions!
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Materials available here: https://t.co/2hi1oZTLQr including a simulator, the slides and the script. Please feel free to use these materials, with acknowledgement to Sam Hoare at Pharmechanics.
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