Shields Lab
@Shields_Lab
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We aim to understand how the supporting stroma of the tumour micro environment regulates immune activity from early stages of disease to promote carcinogenesis.
London, England
Joined March 2019
What an absolutely fantabulous day of talks at @TheBACR Tumour Microenvironment and 3D modelling meeting in Nottingham.
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In vivo fluorescent labeling and tracking of extracellular matrix | Nature Protocolsm
nature.com
Nature Protocols - A protocol for broad-spectrum, in vivo fluorescent labeling and tracking of extracellular matrix proteins through the systemic or local application of N-hydroxysuccinimide...
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Cool!
Endothelial antigen presentation is not made for T cell trafficking... very happy to finally share this study with all of you -
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Who and what is transported from tumours to lymph nodes, and how does it impact tumour immunity? Can we use lymphatic cargo to identify breast cancer earlier and predict disease progression? Just one day left to apply for this exciting project and find out.
Applications now open! Join us @KCLcancer_pharm and be part of an exciting @CRUKresearch funded project to identify if we can exploit the lymphatic system for cancer #EarlyDetection and better predict patient outcomes
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Happy we could play a small role in this fab story out in @CD_AACR. Check out @doctor_kno’s tweetorial!
We are excited to share our new paper published in @CD_AACR about the molecular similarity between pre-cancerous Barrett's esophagus (BE) and Gastric Intestinal Metaplasia (IM). @RFitzgerald_lab @nygenome @Cancer_dynamics @EarlyCancerCam
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Neutralization of NET-associated human ARG1 enhances cancer immunotherapy
science.org
Immunosuppressive ARG1 is cleaved by CTSS to a functionally active form in NETs released by activated neutrophils of patients with PDAC.
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Applications now open! Join us @KCLcancer_pharm and be part of an exciting @CRUKresearch funded project to identify if we can exploit the lymphatic system for cancer #EarlyDetection and better predict patient outcomes
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Just one week left to apply for our exciting project investigating the potential of localized magnetic thermal therapy to reprogram the tumour immune microenvironment. Come join us!
Are you interested in developing new ways to treat cancer and understanding how they work? Why not come join us at the brilliant #CancerCentre @KCLcancer_pharm
https://t.co/Ku8OTB7Dpo
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Thanks to @CRUKresearch support we can get cracking on answering this! We will be recruiting imminently, so please keep an eye out if #lymphatics and #EarlyDetection are your thing
Is it possible to exploit the lymphatic system for cancer #EarlyDetection? This is what @Toastyjac (@KingsCollegeLon) will study, to build a better understanding of #BreastCancer progression & identify early drivers of cancer spread to better predict patient outcomes [2/4]
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Are you interested in developing new ways to treat cancer and understanding how they work? Why not come join us at the brilliant #CancerCentre @KCLcancer_pharm
https://t.co/Ku8OTB7Dpo
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Really lovely story from @immunonoah. Happy we could play a small part in a great collaboration
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Extremely proud of this guy @Corrado___M for passing his PhD viva yesterday. Thanks to his examiners and coPI @Biointerface_CU. Congratulations Dr Mazzaglia!!!
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Fully funded MRC DTP PhD studentships for 2023 available @KCLcancer_pharm, including our lab!! Top training within a collaborative and supportive environment. Apply by 9th November https://t.co/bPGMBJPxK7
kcl-mrcdtp.com
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Come and join the fabulously collaborative network that is @KCLcancer_pharm ! 👇
We are recruiting a Postdoctoral Computational Biologist in the team to work collaboratively across the Cancer Centre @KCLcancer_pharm to decode #RNAseq #FACs #CyTOF datasets to uncover new insight into the microenvironment in #Cancer. @CRUKCOLcentre 👇 https://t.co/j085QaXYmc
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Exciting data from the @IrshadLab_: what happens to the tumour microenvironment of high-risk chemotherapy resistant breast cancers?
Delighted to have our deep dive into understanding the #tumourmicroenvironment of high-risk chemotherapy resistant breast cancers published in @CCR_AACR today!! @KCLcancer_pharm @ICR_London
@CRUKresearch
https://t.co/LJdn3Ks9ux
https://t.co/aQlpdnvD3G
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This is a great opportunity for lovers of tumour immunology. Exciting work, top PI @CoffeltLab and amazing facilities!
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Hepatic macrophages are more heterogeneous than once thought: the markers that define them, the signals driving their development and their unique functions in the healthy and diseased liver. @ImmunityCP @KC_DC_01 @MartinGuilliams
https://t.co/7JCm83KQWe
cell.com
Hepatic macrophages are more heterogeneous than once thought. In this perspective, Guilliams and Scott discuss what is currently known regarding the distinct macrophage populations, the markers that...
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Does ECM composition determine immune cell phenotype? Yes! In our new work on #ECM #immunity, we found tumour ECM induces a population of TAMs found in ovarian cancer with tissue remodelling and immunoregulatory properties. https://t.co/UqRO55b0Xq
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I am thrilled to share our paper with you all today! We unraveled how dural lymphatic vessel dysfunction assists the behavioral response to peripheral inflammation:
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Immunology peeps - this is a great opportunity in an awesome lab!!
🚨We’re Hiring! 🚨 Come join our lab led by Dr Sheeba Irshad! 🙌 Details below👇
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