SantosLaB
@SantosLaB8
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Quantitative biologist passionate about how stem cells make decisions @TheCrick. Alumni: @EMBL @Stanford. Fosters mentorship. ENTP. 7&2. Mom. ScubaDiver.
London, England
Joined September 2018
Our latest work ✨ led by the incredibly talented @OliverCKInge PhD student in the lab with many @TheCrick friends and collaborators ❤️
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling.
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Outstanding talk today at #CABDseminars by Silvia Santos @SantosLaB8 ! Silvia showcased the latest work understanding the deciding cellular signals during early human development. Silvia was hosted by Fernando Casares. Thanks for coming Silvia!
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.@OliverCKInge and colleagues at the @SantosLaB8 explored how activin and bone morphogenetic protein 4 (BMP4) guide fate specification during human #gastrulation. Activin and BMP4 signaling determine the choice between alternate developmental routes. | @TheCrick
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Beautiful story from @OliverCKInge @SantosLaB8 on endoderm specification. Really enjoyed being involved with this project.
Online now: Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
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Congratulations Ryan and @jvveenvliet and all the team! 🎉👏 I am happy to have been able to help a bit make this happen. Really useful quantitative analysis for gastruloids and beyond! I am sure it will enable many discoveries 😃
(1/14) I’m happy and proud to introduce: SpinePy – a framework to detect the "spine" of gastruloids and measure biological and physical signals in a local dynamic 3D coordinate system. https://t.co/kCzfVxSucd
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Online now: Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
cell.com
Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4...
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Special thanks to the @TheCrick comms team for making the work accessible to all in this piece https://t.co/TpVmbYCLdf
crick.ac.uk
By tracking the fate of individual embryonic stem cells, researchers have found that endoderm cells – early embryonic cells that give rise to tissues such as the gut and lungs – originate from...
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Excited to co-organize the Keystone Symposium “Stem Cell Models in Embryology” with Jianping Fu and @EbisuyaMiki! Join us Feb 17–20, 2026 at Asilomar to explore cutting-edge advances in stem cell–derived embryo models. Spread the word! https://t.co/rd2kE1mRbU
#KSEmbryology26
keystonesymposia.org
Join us at the Keystone Symposia on Stem Cell Models in Embryology, February 2026, in Pacific Grove, with field leaders!
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In the latest issue! Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development
cell.com
An embryonic stem cell-based 3D model that accurately recapitulates the size, morphology, and functional features of the human amnion at 4 weeks, termed the post-gastrulation amnioid (PGA), is...
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A big mission of @crick.ac.uk is to bring Science to everyone. Thank you chris agathangelou and Clare green for your help with making our latest work on a new stem cell model of the human amnion accessible to all 🙏 https://t.co/EyOhZHLYpf
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Interested in Photoreceptors, Photobiological Responses and Optogenetic Applications across species? Join us at the GRS & GRC 2026 in California on Feb 7. https://t.co/YBU64NxMb7 Share your work with the photobiology community! Abstracts will be selected for oral presentations.
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Today at @CellSystemsCP we report in back-to-back papers (!) led by @nbwang22 on how cell state potentiates the influence of individual transcription factors to drive cell-fate programming & how we used these insights to scale up production of motor neurons from primary
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We joined Bluesky a couple of weeks ago after a long break from social media. Come join us there too @santoslab.bsky.social.
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Thanks so much @stemcellpodcast for highlighting our work @TheCrick! 24:00-32:00
Drs. Borzo Gharibi, Silvia Santos, and a team at @TheCrick generated an ESC-derived 3D model of the post-gastrulation #amnion. 📄 @CellCellPress - https://t.co/44VZC1Hyne 🎤 - https://t.co/K6Kk70JuLK
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3D stem-cell-derived model of the amniotic sac complete with fluid – closely resembling that found in pregnancy 📹 Borzo Gharibi et al The Francis Crick Institute, London in @CellCellPress ➡️ https://t.co/WzG4RKtVlg
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3D human #amnion model. We are a veritable cellular lego https://t.co/ltGC92TD2c Very good piece of work, with a focus on the important aspect of this organ #physiology. @SantosLaB8 #CellsRUS #SCBM #EmbryoModels
cell.com
An embryonic stem cell-based 3D model that accurately recapitulates the size, morphology, and functional features of the human amnion at 4 weeks, termed the post-gastrulation amnioid (PGA), is...
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It is with my heart broken that I share that Philippe Bastiaens, Max Plank Director and my PhD advisor has passed away 💔. Philippe had a huge impact in my life and where I am today. His premature passing is heartbreaking. DM me if you would like to be informed of next steps. 🙏
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🔥 Today in @CellCellPress! Drs. Borzo Gharibi & Silvia Santos (@SantosLaB8) led this study showing that GATA3 is required and sufficient for #amniogenesis and BMP and Wnt signals from the amnion contribute to amniogenesis. @TheCrick
https://t.co/TsOfbrd1CA
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