🥁 Our manuscript "Multistate and functional protein design using RoseTTAFold sequence space diffusion" is finally out @NatureBiotech! 🧵b/c it's changed a LOT since preprint! New highlights: - High res structures - Conditionally caged peptides - Multistate design

🚨Today in @NatureComms: We resolve an enduring enigma in T cell biology—how TCR binding to p/HLA triggers intracellular signaling. CryoEM in native environment reveals a 'jack-in-the-box' mechanism! Collab btw @RockefellerUniv @MSKCancerCenter @parkerici https://t.co/HJng8WvjOp

Researchers use #AI and Reverse Vaccinology 2.0 on human blood samples to identify a potential new mpox target, and use the target in a vaccine that elicited mpox-neutralizing antibodies in mice. @ScienceTM https://t.co/xl05ZBCoIL

Excited to share my recent work, CIRPIN 🐍 with @sokrypton and @MazAbulnaga on the discovery of thousands of naturally occurring circularly permuted protein domains

What if we have a big protein but need a smaller version for delivery or engineering? Introducing SCISOR: we shrink proteins by training a diffusion model to find natural substrings! arXiv: https://t.co/hxk2ilSIOf @EthanBaron78553, @ruben_weitzman, @deboramarks, @andrewgwils! 1/7

New paper “Proteome-wide model for human disease genetics” is now live at Nature Genetics: https://t.co/3UKcPlepDV popEVE ( https://t.co/HuxeGfe0g0) finds the needles in the haystacks of human genetic variation:

🚨 New Results Alert 🚨 Have you ever wondered what new therapeutic avenues would be enabled if we could program T Cells in the computer to target any desired peptide-MHC neoantigen with a TCR or a TCR-like antibody? What if we could validate these molecules easily in small

Delighted to share the peer-reviewed version of our article describing a prefusion-stabilized MARV GP vaccine immunogen and a best-in-class MARV neutralizing and protective antibody! Led by Amin Addetia with @VirBiotech @HHMINEWS https://t.co/SI78iXWkef

🚀 New Paper: We’ve just released HalluDesign – a novel framework for protein optimization and de novo design using AlphaFold3-style models, without finetuning or gradient backpropagation! 🎉 https://t.co/tmqKqPMp2b

Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵 https://t.co/E2fZXw2Pom

🚨new paper alert🚨 Here, we show how recently developed ML tools can be leveraged to design self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the oligomeric building blocks. Read more @PNASNews: https://t.co/ZTaO9m1X4x

Morphed transition of the intermediates in the catalytic cycle of the yeast TRiC chaperone (PDB codes: 6KRD, 6KRE and 6KS6) @UCSFChimeraX #molecularart #scivis

How can we computationally design new peptides that activate T cells against cancer and viruses?@UW @PNASNews "T cell receptor specificity landscape revealed through de novo peptide design" • T cells recognize pathogen-derived peptides presented on MHC molecules through T

🚨 new paper in @ScienceTM 🚨 Here, we describe and evaluate a "best-of-both-worlds" vaccine technology platform that combines the benefits of mRNA vaccines and computationally designed protein nanoparticle immunogens: https://t.co/E7jl0fYInN.

This week's issue of #ScienceTranslationalMedicine has arrived! New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://t.co/mfA8HqzCYv

Looks like a scrotum mixed with the hot sauce guy from SpongeBob

We are pleased to share our new preprint: “De novo design of RNA and nucleoprotein complexes”. This work extends the principles of de novo protein design to RNA and DNA, enabling the generative design of complex multi-polymer structures! (1/6) https://t.co/QPqpNZr0er

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8) Preprint: https://t.co/iIucGbMSDp

Thrilled to share that today we report our human protein interactome in @ScienceMagazine! Predicting which pairs of proteins in the human proteome is a great challenge due to the shallow eukaryotic evolutionary signals but hugely important to understand.

We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.

Trust me.