Signal Transduction & Metabolism Laboratory
@STMLab_ULB
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In the Gurzov Lab, we foster research excellence and pursue discoveries in metabolic disorders, with experts working together in a collaborative team.
Brussels, Belgium
Joined December 2017
Our project REPRO-PTP has been selected for funding! šš #ERCPoC @ERC_Research. This is a major milestone in translational research for our laboratory (. @ULBRecherche @NCP_frsFNRS @WELRI_asbl.
š£ Out now! Final results of the 2024 ERC #Proof of #Concept #Grant call for proposals for #funding. 134 researchers will receive ā¬150k each to explore the commercial or societal potential of their frontier #research results. š #ERCPoC @EUScienceInnov
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RT @sumeetpalsingh8: We just posted our new preprint, spearheaded by Garnik Hovhannisyan with @STMLab_ULB ! #zebrafā¦.
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We have generated human TXNIP knockout stem cells for metabolic studies. This initial work can facilitate future efforts in TXNIP-targeted therapies and drug screening, offering valuable controls to test specificity and efficacy.
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RT @DanielJDrucker: Mouse and human data suggests that a potent SCFA immunomodulator promotes multiple beneficial pathways and supports tarā¦.
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Our latest Review article is online! š @Gilglioni1 @hay_dave Therapeutic potential of stem cellāderived somatic cells to treat metabolic dysfunctionāassociated steatotic liver disease and diabetes - Gilglioni - Obesity Reviews - Wiley Online Library
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RT @TheLancetEndo: We provide herein an overview of #hypothalamic #obesity, departing from the hypothalamic pathways governing bodyweight aā¦.
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RT @LGMartelotto: What if single-cell analysis of 1,000 samples wasnāt just imaginableābut affordable?. Imagine analyzing 1,000 samples atā¦.
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RT @sumeetpalsingh8: A huge shoutout to the amazing PhD student @selifeski who lead the project, helped by @macotaa, our amazing team, collā¦.
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RT @TheLancet: Despite the diverse nature of obesity, there is compelling evidence that suggests brain circuits play an important role. Aā¦.
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We are very happy with the award! š.
The moment we've all been waiting for! š. š Awarded our top post of 2024 is work led by Dr. @Gilglioni1 at @STMLab_ULB. It underscores the role of PTPRK in the metabolic reprogramming of hepatocytes induced by obesity.
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It was very exciting to participate in the FASEB Protein Phosphatases conference at Palm Springs, CA #PROSRC
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RT @Teresa_IDF1: Happy to have joined the Convening Emerging Leaders to Find T1D Solutions meeting in Charlottesville. Thank you to the Manā¦.
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RT @frsFNRS: Comment l'obĆ©sitĆ© favorise le dĆ©veloppement du cancer du foie ? DĆ©couverte du Laboratoire Transduction du signal et mĆ©tabolismā¦.
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Our @frsFNRS Aspirant PhD student won the Best Poster Award at the meeting of the Belgian Society for Stem Cell Research (BeSSCR). Look how happy she is! š Well done @ValerieVanden14! #BeSSCR #StemCells
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RT @TSESystems: Leveraging the TSE Systems PhenoMaster NG platform, Dr. Gurzovās team @STMLab_ULB explored the regulatory pathways of RPTPsā¦.
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Our new paper is online! We have a nice tool to assess glycolysis in cells. Fantastic work of @Israelhabanero and collaboration with @MessensLab! Tracking fructose 1,6-bisphosphate dynamics in liver cancer cells using a fluorescent biosensor: iScience
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The study postulates PTPRK as a dual player - serving as a biomarker for hepatic metabolic adaptations that influence metabolic liver disease risk and as a potential target for the development of new therapies.
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In mice, genetic deletion of PTPRK offers protection against the rapid progression of fatty liver in an obesogenic diet and the development of liver #cancer.
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Here we found that PTPRK expression is increased in #obese human and mouse livers. Elevated hepatic expression of PTPRK triggers enhanced glycolysis, culminating in PPARĪ³ activation and de novo lipogenesis. @ULBRecherche.
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