🚨 Just out in Nature Communications:. Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish.We challenge old assumptions on liver regeneration!.🔗 🧵(1/8).

Excited to co-edit a @FrontPhysiol Research Topic on Intercellular Calcium Signal Propagation in Tissue Function!.We're inviting original research & reviews on how calcium signals shape tissue behavior. Submit your work:

Delighted to share the first submission from our @ShivNadarUniv @dls_snioe lab to @ANRFIndia ! Grateful to @MotianiRaj1 & Dr. Savneet Kaur for encouraging a junior PI like me to lead with the highest funding request, while seeking much less for theirs. 🤞.#AlcoholicLiver

Afternoon stroll in the biodiversity park @ShivNadarUniv . Saw a flying peacock but couldn't click its pic.

View from @ShivNadarUniv library #grantwriting

RT @Ishwariya13: This right here is what we live to see.A new gene treatment from the lab that causes axons (green) to grow through a sharp….

RT @Ishwariya13: 🚨🚨Dropping our 2nd V-Lab preprint, this time on work led by @Yogeshsahu2030 🥳! We identify 2 novel regulators of CNS axon….

RT @SanjeevSaGa: Stoked to announce our new preprint describing mechanism of SATB1-dependent chromatin interactions & its interplay with a….

If you’re interested in liver regeneration, cholangiocyte biology, or cell fate plasticity, we’d love to hear your thoughts!. #LiverRegeneration #Zebrafish #RegenerativeBiology #CellPlasticity.(8/8).

🙏 Funded by @frsFNRS and @DBTIndia , whose support was essential. 🐟 This study also highlights the power of #zebrafish as a model for dynamic cell plasticity and #regeneration. 🔗 Full paper: 🔗 Lab: (7/8).

Huge thanks to our team:.👏 Lead author @selifeski .👏 Co-authors @JiaruiMi @macotaa Garnik Hovhannisyan.👏 Collaborators @O_Andersson_Lab @STMLab_ULB. @RitaManco3 @FedeBioinfo .(6/8).

This reveals that cholangiocyte plasticity is not just a backup plan, but an active, physiological response during liver growth and moderate injury. A new paradigm: transdifferentiation can occur without senescence, fibrosis, or chronic damage. (5/8).

Surprisingly, de novo hepatocytes emerged even when spared ones were present—a key deviation from the idea that cholangiocytes only activate after massive hepatocyte loss. We confirmed this with a 17% partial hepatectomy model. ✂️🐟.(4/8)

Enter CellCousin: a new zebrafish tool we designed to trace liver regeneration. 🟢 Spared hepatocytes.🔴 Ablated hepatocytes.🔵 De novo hepatocytes (not hepatocytes before injury).This lets us precisely map where new hepatocytes come from after injury. (3/8)

The liver can regenerate itself—a fact known since the myth of Prometheus. But when hepatocytes are damaged, can cholangiocytes step in to rebuild the liver even if some hepatocytes remain?.We built a new zebrafish model to test it. (2/8).

Pleased to have contributed commentary to this recent article by @1989_mariab for @IntEngineering , which explores the science of tissue #regeneration and its potential applications in medicine.

The @Lim_Labo lab is a pioneer in study of 14-3-3 and metabolism. Don't miss out this opportunity!.

Huge thanks to the team and funding support @frsFNRS @DBTIndia that made this happen 🙌.We hope CellCousin2 helps others studying regeneration, cell fate, and tissue repair. All plasmids are available on @Addgene .

How does DDCreER work?.We fused CreER to a destabilizing domain (DD) that is degraded unless stabilized by TMP. 💊 TMP = protein stabilization.🟣 4-OHT = nuclear translocation.Only when both are present does recombination occur—ensuring tight temporal control.

What’s new in CellCousin2?.✅ DDCreER: chemically inducible Cre with low leakiness.✅ NTR2.0: ablation with 10× less metronidazole.✅ Cleaner, more precise regeneration readouts.The system is modular and adaptable to other tissues or models.