Beatriz Rico
@Rico_lab
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We are interested in understanding how genes are involved in the development of neuronal circuits
London, UK
Joined December 2013
RT @dev_neuro: We're #hiring! Looking for an experienced and dynamic Research Strategy Manager. More details in link below.Deadline 09 Ju….
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RT @Interneuron_Dev: Our study on the impact of altered serotonin (5-HT) signalling on developing sensory cortex is now live @NatureComms….
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RT @MarinLab: 1/10 Our latest research, led by @MartijnSelten, identifies a mechanism through which Parvalbumin (PV) interneurons regulate….
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12/12. Here’s the paper @NatureComms if you want to dig in: Thanks to @wellcometrust for funding, and thanks to everyone for sharing! @dev_neuro @MRC_CNDD @KingsIoPPN.
nature.com
Nature Communications - How cortical interneurons establish precise connections among intermingled populations of excitatory neurons remains unclear. Here, the authors reveal that Cadherins...
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11/12. Our findings reveal a molecular and cellular code that orchestrates the assembly of inhibitory microcircuits targeting distinct pyramidal cell populations.
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10/12. The differential inhibition signature is acquired during the initial steps of synaptogenesis and regardless of the pyramidal cell’s position, suggesting that connectivity features might be part of L5 cell type identity.
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9/12. We revealed a minimal overlap between IT and ET presynaptic inhibitory networks, suggesting that different PV+ basket cell populations innervate distinct L5 pyramidal cells.
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8/12. To explore whether the PV presynaptic partners were different, we engineered a multiplex monosynaptic tracing approach to simultaneously visualize the presynaptic networks of two different neurons.
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7/12. The same cadherin plays a distinguished role in each pyramidal cell.
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6/12. We identified two members of the Cadherin superfamily, Cdh12 and Cdh13, that contribute to cell-type- and input-specific perisomatic inhibition. Cdh12 mediates CCK+ inhibition onto L5 IT neurons, while Cdh13 conducts PV+ inhibition onto L5 ET neurons.
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5/12. How is this achieved? Our study demonstrates that pyramidal cells, by expressing a unique cell-surface molecule signature, could shape basket cell interneuron wiring to drive cell-type-specific inhibitory connectivity.
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4/12. We found that in the somatosensory cortex, L5 intra- (L5 IT) and extra-telencephalic (L5 ET) pyramidal cell populations receive different ratios of PV+ and CCK+ inputs.
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3/12. For example, in Layer 5, neighbouring pyramidal cells receive distinct levels of inhibitory inputs.
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1/12. How do cortical interneurons select specific pyramidal cells during development? Julie Jezequel in @Rico_lab has identified specific cellular and molecular codes that interneurons use to target pyramidal cell types @NatureComms @dev_neuro @MRC_CNDD @KingsIoPPN
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RT @Sergiu_P_Pasca: In this week’s @Nature, we publish a group effort to outline a framework for studies with neural #organoids, #assembloi….
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RT @ruimcosta: Science Matters. 🧪🔬🚀.I am alive because of science. We all benefit from science — every day. Science is in our homes, our ho….
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Congratulations, @GuilleLBendito and @GLB_Lab, beautiful work!.
🚀New paper out! Can somatosensory maps be reshaped before birth? We reveal a critical embryonic window where prenatal mystacial whiskers deprivation reorganizes facial maps, expanding upper lip representation, refining map resolution & enhancing function.
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RT @BrainPrize: Congratulations to winners of The Brain Prize 2025!.Professors @michelle_monje, @StanfordMed and @HHMINEWS Investigator, an….
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RT @MasudHusain: Why academia is sleepwalking into self-destruction. My editorial @Brain1878 If you agree with the sentiments please RT. I….
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