Kavita Rawat
@RawatKSM
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Senior Scientist @WUSTL, Postdoc @Dartmouth @DMS_Microimmuno , Mom 👨👩👧, Immunologist
St Louis, MO
Joined September 2020
Don't know how Sipuleucel-T (Provenge) works - or how we can make it better? 🤔 Check out our hot-off-the-press review in @jitcancer 🔥 Sip-T was the FIRST approved cellular vaccine therapy for ANY cancer (2010)! https://t.co/GTz2mKAzXg
jitc.bmj.com
Clinical trials of immunotherapy in metastatic castration-resistant prostate cancer (mCRPC) have largely been unsuccessful despite promising preclinical studies and proven efficacy in other solid...
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Meet our next #FASEBLEAD reverse mentoring pair: @RawatKSM, Senior Scientist @WUSTL, teams up with Titus A. Reaves, Associate Professor @MedUnivSC. Excited to see the fresh perspectives they'll bring! 🌟 Learn more about the pair: https://t.co/tAqcSE80Dq
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Natural antibodies drive type 2 immunity in response to damage-associated molecular patterns: https://t.co/lXRH4l55M7
@claudjak @GeiselMed
#Immunology
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Delighted to share our recent findings exploring the involvement of B1 cells and Natural antibodies in DAMP-induced airway allergic disease. @JCI_insight @ArlindUC17 @claudjak
Ever wondered how DAMPs initiate type 2 inflammation? Turns out B1 B cells and natural antibodies are involved! Read more about how we used Allergic Airway Disease as a model to show their involvement @JCI_insight
https://t.co/WNL36hUfoH
@RawatKSM @claudjak
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Had a fabulous visit at UAB with Fran Lund, Troy Randall, Andre Ballesteros-Tato, Bea Leon-Ruiz, and John Kearney, B1 cell guru- Loved that he (pic of our paper on his desk) asked me questions about our JI NAb story! So very cool.
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A grateful couple has donated $500,000 to advance #immunotherapy research in the lab of @RPachynski @WUSTLmed. Their support aims to power crucial #cancer breakthroughs. https://t.co/OjnBGYnI1B
siteman.wustl.edu
In 2016 while receiving treatment for bladder cancer at Siteman Cancer Center, Kerry Preete frequently engaged in conversations with his Washington University medical oncologist, Russell Pachynski,...
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This was a fun study beyond our usual focus. We asked, 'When and how do congenic markers and nonimmunogenic antigens elicit immunity in their hosts?' Turns out, it happens quite often, especially in cells with low immunogenicity. @RawatKSM @ArlindUC17
https://t.co/poBrIvdzNH
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Congratulations @RawatKSM!!!
Congrats to Kavita Rawat for being a FASEB CARES recipient! She is a research scientist in the Department of Microbiology and Immunology @GeiselMed. Rawat's research investigates natural antibodies' role in immune surveillance during cancer development. https://t.co/eaJxN6GaTF
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Our work on perforin-2, a pore-forming protein expressed by #DendriticCells to deliver antigens into the cytosol during #CrossPresentation is now out in @ScienceMagazine
https://t.co/ZdFoAyFQR2… Huge amount of work from Pablo, in collaboration with @laub_marco & @Pati_Krawczyk
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Perforin-2 facilitates antigen translocation to the cytosol in cross-presenting dendritic cells @patrycja_kozik
https://t.co/CenA1C7ZuX Comment in @ScienceMagazine by @claudjak @RawatKSM
https://t.co/ks5p7T3ZhL
science.org
Perforin-2 facilitates antigen translocation to the cytosol in cross-presenting dendritic cells
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Thrilled to share our preprint. Interstitial macs unbiased clustering is due to conserved chemokine expression patterns, resembling T cell biology with cytokines 👇 IM-depleting 🐭showed their major role is orchestrating leukocyte recruitment in TLOs. https://t.co/4Q2mBJYL0h
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I will be presenting my work on monocyte migration at #KSMyeloid23. My poster is available for viewing today, and I will deliver a talk tomorrow.
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Excited to share our new findings on how moDCs lacking CCR7 transport Ag from the periphery to the draining LNs, where they regulate DC-mediated immunity. @RawatKSM @bart_lambrecht CCL5-producing migratory DCs guide CCR5 monocytes into the draining LNs https://t.co/qFlFEgTsmx
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In @JExpMed, @RawatKSM, Tewari, @Claudjak et al. show that dendritic cells use the chemokine receptor CCR7, while monocytes follow chemokines secreted by migratory DCs to reach lymph nodes and control immunity. https://t.co/uqln8J04qc
@ArlindUC17 @NnamChinaza @bart_lambrecht
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.@RawatKSM, Tewari, @Claudjak et al. @GeiselMed show that dendritic cells use the chemokine receptor CCR7, while monocytes follow chemokines secreted by migratory DCs to reach lymph nodes and control immunity. https://t.co/9RYrCoTFgB
@ArlindUC17 @NnamChinaza @bart_lambrecht
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Religion is a culture of faith; science is a culture of doubt.
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#JI_TopRead from @claudjak & @RawatKSM @m2p2_dartmouth | demonstrate that #NaturalAntbodies can recognize & eliminate transformed cells early in #tumorigenesis | #tumorimmunology #FreetoRead #ReadTheJI #immunology @GeiselMed
https://t.co/gqjffZh7YA
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Excited to share our Lung Macrophage review with @bart_lambrecht and @Helligator
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SPOTLIGHT: Natural Antibodies Alert the Adaptive Immune System of the Presence of Transformed Cells in Early Tumorigenesis @GeiselMed @RawatKSM @claudjak. Originally published in @J_Immunol. To read our summary click https://t.co/JVdsZ3Mi7v and scroll all the way down.
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NAb-deficient mice develop uncontrolled tumors (2nd lung), naive serum can rescue the anti-tumor response (4th lung)
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