Ratmir Derda
@RatmirDerda
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Rewind the time and let it go forward: will we, or nature, make the same discoveries and innovations? Seeking ways to test "Reproducible Discovery" hypothesis.
Edmonton, Alberta
Joined October 2017
Remember The Glycans: Consideration of Glycans in Evaluating the Threat of Mirror-Image Life Forms https://t.co/d3fE2tthux by 32 #glycobiology PIs @ChemicalBiology @CarolynBertozzi @GlyCosmos @peterseeberger @daniel_bojar @FeiziTen @Lowarylab @sjwill99 et al #RememberTheGlycans
science.org
Broad discussion is needed to chart a path forward
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"Later but Better" -- nice title for this highlight of our work (thank you, Guoqing Jin!)
nature.com
Nature Reviews Chemistry - A new approach to reshape a set of peptide candidates into stable, drug-like macrocycles has been developed to better target large protein surfaces.
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To distract everyone from the devastating NIH news, I recommend reading this Mirror Image Life discussion in Science magazine https://t.co/d3fE2tthux or popular press https://t.co/eEasWsa0OT and our view on this topic: TLDR: do not forget about Glycans!
biorxiv.org
Cross-chiral recognition in glycobiology is the interactions between biologically conventional proteins and the enantiomers of biological glycans (e.g., L-proteins binding with L-hexoses) from...
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Congrats to GlycoNet Investigator, Dr. Matthew Macauley from @Ualberta, the 2025 X-Chem Research Excellence Award winner! His work on Siglec-glycan interactions is advancing immune system research. Read more: https://t.co/OCEFnzEwML
#glycotime #Glycoimmunology #Immunology
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Next at #SFG2024
@RatmirDerda talks about is liquid arrays to study glycan-lectin interactions, e.g., effect of ligand density on Siglec binding or effect of high expression of a lectin on a cell line. Also detection of glycan ligands or lectins binding to tissues in a mouse.
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Congratulations to Kejia Yan @yantwohappyyyy the lead on the most complex and comprehensive @acsJACS publications from @derda_lab to date. Big thanks to @48HourDiscovery and Dustin Maly Lab for their contribution. See "late stage reshaping" paper at https://t.co/n5CCXgCqns
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I finally know how it feels like to own a Ferrari. Every morning my email goes from 0 to 60 unread emails in 2.4 seconds.. sends shivers down my spine
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DNA-encoded, Liquid Glycan Array (LiGA) and its application to cell-surface profiling is out in @NatureProtocols . Big thanks to @miratsojitra for leading the effort and @MatthewMacaule4 + members of Macaluley Lab and @derda_lab !
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Calling all Chemical Biologists in Canada and beyond. Submit your abstracts to the Canadian Society Conference (CSC) in June 2024. Deadline Extended to Feb 6. Check out the Chemical Biology session organized by myself and Fred Menard (UBC) https://t.co/Qk9iPZyTk9
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Apologies: ran out of characters: BIG thanks to @MatthewMacaule4 Lab @JameZeynab + Eddie @glycocode Lara Mahal, Claire Yang+Justine Lai in Raymond Lai's Lab (UofA Oncology), Gisele Monteiro, super-alumnus @miratsojitra and of course, the fearless leader: Guilherme Meira Lima
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I'm curious about any feedback from #Glycobiology #glycan #carbohydrate #glycotime community on @derda_lab preprint on DNA-encoded liquid #lectin arrays (LiLA). [LiLA] non-lineary amplifies detection of compositional differences of the cellular #glycocalyx
https://t.co/O1kAGlHjqV
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Big shout out to all collaborators on a paper that finally came out in @NatureComms with @Fe_Will26 @Yu_Shan_Lin @MatthewMacaule4
https://t.co/cNFpE1vNHf , @Vukovic_Lab, Vederas Lab and many contributors from @derda_lab @JeffYKWong @ARUNIKAEKANAYA1
nature.com
Nature Communications - Peptide-based therapeutics are promising therapeutic modalities, however, their prevalent drawback is poor circulation half-life in vivo. Here, the authors report the...
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Congratulations to our superstar undergrad @ryannqiu for winning the best oral presentation award at the #wcucc2023!!! Very well deserved for all his hard work and dedication.
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Check out this article on our collaboration with the Macauley and Hubbard labs! Thanks to Hansol and everyone for their hard work on the project! https://t.co/cpV2t9K5yP
@BazHubbard @Hansol_Chemist @MatthewMacaule4
crisprmedicinenews.com
At a length of around 100 nucleotides, single guide RNAs are not synthesised efficiently. However, thanks to click chemistry, they can now be synthesised efficiently as three short fragments that...
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Big up to Tracy (Chih Lan) Lin @tracy6528, @miratsojitra, Eric Carpenter and others @derda_lab with @MatthewMacaule4 and @Lowarylab for release of the new Liquid N-Glycan Array (LiGA) made via Chemoenzymatic Synthesis. Check it out!
biorxiv.org
A hallmark of cellular glycosylation is its chemical complexity and heterogeneity, which can be challenging to capture synthetically. Using chemoenzymatic synthesis on M13 phage, we produce a...
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From the University of Alberta, @CanadianPeptide CPPC student representative @ARUNIKAEKANAYA1 wins an oral presentation award at the @ampepsoc symposium! #peptides2022 @ualbertachem @derda_lab
One of our "Young Investigators," Arunika Ekanayake from University of Alberta, presents her very well received "Genetically Encoded Fragment-Based Discovery, GE-FBD, from Covalent and Non-Covalent Pharmacophores" talk. #Peptides2022
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Today is the international "you have 0 unread emails" day! (celebrated by various academics worldwide once a year around this time in summer). For reviewers who don't believe me, see Figure 1 below:
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