Todd L. Lowary
@Lowarylab
Followers
1K
Following
57
Media
29
Statuses
933
A group of chemists interested in the role of carbohydrates in (microbial) disease @IBCSinica. Opinions are my own.
Taipei, Taiwan
Joined January 2014
Ahh yes. Cellulose, a polymer of pentoses. @angew_chem Do better, please.
onlinelibrary.wiley.com
We report a molecularly engineered cellulose trimellitate ester (PCLA) quasi-solid polymer electrolyte with dual-donor and anion-π motifs. C═O/COOH groups coordinate Li+ and anchor TFSI−, while an...
3
3
34
🔬Publication - by Dr. James C. Liao @ScienceMagazine Plants, such as #Arabidopsis #thaliana, with dual #carbon dioxide fixation systems -- CBB and McG cycles -- can fix one additional carbon and show enhanced #protein, #lipid, growth, and seed yield.
science.org
Carbon fixation through the Calvin-Benson-Bassham (CBB) cycle accounts for the majority of carbon dioxide (CO2) uptake from the atmosphere. The CBB cycle generates C3 carbohydrates but is inefficient...
0
5
6
🔬Publication - by Dr. Yusuke Nasu @ACSPublications Three versions of self-complementing #bipartite #fluorescent proteins are split into fragments of β-strands and converted into bipartite #calcium ion for visualization at MERCs. https://t.co/QcN36LUloJ
#protein #Biosensors
pubs.acs.org
Self-complementing bipartite fluorescent proteins (FPs) are useful tools for the detection of protein–protein proximity and for localizing fluorophores to membrane–membrane contact sites. Here, we...
0
4
8
🚀 New publication from Academia Sinica! @asibc512 Danny Hsu’s team at Academia Sinica has uncovered how an engineered ribosome arrest peptide (eRAP) can precisely control the rhythm of protein synthesis.
academic.oup.com
Abstract. Ribosome stalling is a critical regulatory mechanism in protein synthesis, controlling the rate and fidelity of translation. Arrest peptides, sho
0
1
3
Excited to share our Nat Comm paper https://t.co/mAANwcSfqf We uncovered by cryoEM how the proteasome recognizes branched K11/K48 ubiquitin chains through a new K11-binding site in the RPN2 subunit, revealing how the proteasome precisely identifies targets for rapid turnover.
nature.com
Nature Communications - K11/K48 branched ubiquitin chains regulate protein degradation and cell cycle progression. Here, the authors report the structural basis of how such a branched ubiquitin...
3
2
1
Interesting. An N-glycan with chitotriose core with one of the residues in the L configuration..... Surely someone can develop an AI-based tool for fixing/preventing these abominations. Thanks Matt Macauley for the tip. @Nature #badglycans
https://t.co/n9LBhRL0MX
nature.com
Oncogenesis - GlycoRNAs are abundant in glioma and involved in glioma cell proliferation
0
0
7
🔬Publication - by Dr. Manuel Maestre-Reyna This study demonstrates the partial accommodation of 8-oxoguanine in the active site, and crystal-packing collapse during the very late reaction stages of #hOgg1. https://t.co/udEdECFayK
#photocage #crystallography #glycosylase
0
1
4
🔬Publication - by Dr. Meng-Chiao Ho @Lowarylab @CellPressNews This study demonstrates the #phage-host interaction of #glycan-binding domains of #mycobacteriophage #Douge during #viral #genome ejection. https://t.co/5EkFrufl4b
#mycobacteria #tuberculosis
1
2
9
If letting people starve is ‘America First,’ it’s not an America I recognize
washingtonpost.com
Too many political leaders today embrace a concept of America as a nation that cares only about itself.
1
0
1
🔬Publication-by Dr. Yusuke Nasu @NatureComms Sex-specific changes in #orexin #neuron firing were primarily driven by #astrocytic mechanisms with elevated #purinergic signaling in male mice and reduced extracellular L-lactate in female mice. https://t.co/81qlYQHl0u
#biochem
nature.com
Nature Communications - Early-life stress has lifelong impacts on neuronal function and behavior. Here, the authors show that astrocytic glucocorticoid receptor signaling drives stress-induced...
0
1
5
🔬Publication - by Dr. Chun-Hung Lin @JCRnEDITORS Targeting #PEGylated #nanomedicines to #netrin-1 in the extracellular matrix or #EphA2 on the #cancer cell membrane can increase their anti #tumor activity. https://t.co/ckYof0lgcm
#biochemistry #biochem #liposome
0
1
4
🔬Publication - by Dr. Tzu-Ching Meng and Shu-Yu Lin @JCI_insight This study shows that Calm1 gene #mutant heart accumulate high levels of N98S-CALM protein, increasing the severity of #calmodulinopathy while stabilizing mutant CALM.
0
1
2
🔬Publication - by Dr. Chun-Hung Lin @CommsChem Studies using synthetic A. #baumannii #lipid A species showed that various #acylation patterns lead to different levels of stimulatory potency and binding mode. https://t.co/QiPFXCvxX7
#acinetobacter #pathogen #infection
nature.com
Communications Chemistry - Acinetobacter baumannii is a major cause of hospital-acquired infections, yet its virulence factors, particularly lipooligosaccharides, are not well understood. Here, the...
0
2
3
🔬Publication - by Dr. Peter Chi @OUPAcademic The assembly of #recombinases on #DNA to form #nucleoprotein filaments is crucial in DNA repair. This study reveals that proteins like SWI5-SFR1 promote uniform filament growth and stabilize DNA binding.
academic.oup.com
Abstract. Homologous recombination is a key pathway for repairing DNA double-strand breaks with high fidelity. The assembly of recombinases on DNA to form
0
1
1
🔬Publication - by Dr. Hsiao-Ching Lin, Chun-Hung Lin, Zhijay Tu @ACSPublications This study identified #enzymes, such as #monooxygenase, cupin domain-containing protein, and #ketoreductase, involved in #epoxyquinoid #biosynthesis in #Aspergillus #oryzae.
pubs.acs.org
Epoxyquinoids possess multiple contiguous chiral centers and reactive functional groups, offering valuable opportunities for drug discovery and chemical biology. Despite their structural diversity,...
0
2
7
🔬Publication - by @Lowarylab @mbiojournal A gene cluster found in #Streptococcus intermedius is with homology to the #Bacillus cereus and #Pseudomonas aeruginosa pel operons, which are required for #exopolysaccharide production and #biofilm formation.
journals.asm.org
SMG species are increasingly being recognized as pathogens. Despite their clinical relevance, little is known about how SMG members transition between asymptomatic colonization and infection. Herein,...
0
2
4
How Taiwan took the American convenience store — and turbocharged it - The Washington Post
apple.news
Convenience stores in Asia give new meaning to the term: Customers can pay bills, ship packages, eat a nutritious meal and — in some locations — work out.
0
0
3
🔬Publication - by Dr. Hsin-Yung Yen @NatureComms With distinct functions, #glycogenin GYG1 and GYG2 coordinate #glycogen synthase and glycogen assembly, thereby modulating #glucose metabolic pathways and #homeostasis. https://t.co/WLbMvBW7AD
#metabolism #diabetes
nature.com
Nature Communications - Glycogenin initiates glycogen synthesis, but its two human isoforms may do more than expected. Here, Weng et al. reveal that GYG2, despite low enzyme activity, drives...
0
1
1
