Very excited to share that our manuscript on cis-eQTL analysis of adipose tissue gene expression in 2,344 samples is now out in Nature Genetics. See thread from lead author @SarahBrotman below.

RT @imartincorena: Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 erro….

RT @MDC_Neville: Excited to share our new preprint in which we address:.(1) Accurate sequencing of sperm at scale.(2) Positive selection of….

RT @R_Rahbari: II'm excited to finally share our study on the mutational landscape and selection dynamics in sperm, now live on medRxiv: ht….

RT @alanjhodgkinson: Several group leader positions available in Dept. of Medical and Molecular Genetics at King's College London (from lec….

RT @SarahBrotman: I am excited to share our preprint describing a collaborative effort to identify conditionally distinct signals in the la….

Our paper in collaboration with @MinaRyten and led by Karishma D’Sa.

RT @nonfiniteloop: Excited to share a local maximum of my grad school roller coaster ride: our paper “The origins and functional effects of….

Our paper led by @anto_zito investigating variation in escape from X-inactivation across tissues, individuals and twin pairs is now published in @PlosGenetics . Many thanks to @A_L_Roberts @_alesssia @Julia_Moustafa @MarioFalchi @TwinsUKres.

Our paper led by @A_L_Roberts on skewed X chromosome inactivation and its relationship with molecular and cellular measures of aging, cardiovascular disease risk, and cancer diagnoses is online at @elife.

RT @lifecourse_KCL: We're recruiting a Chair in Population Health Sciences & HoD of Population Health Sciences. Population Health is a maj….

Our paper investigating ACE2 gene expression in adipose tissue across three cohorts is now online at @IntJObesity. Work led by @Julia_Moustafa in collaboration with Anne Jackson, Li Guan, @SarahBrotman @klmohlke Laura Scott and others.

RT @anto_zito: We conducted a transcriptomic survey to study properties of escape from X-inactivation across tissues and cells in female tw….

RT @Gelironald: **New!** London Genetics Network .- online launch meeting 4th Dec 2020.- early career poster prize.- great speaker line up….

RT @jordanatbell: Recruiting for a 4-year BBSRC-funded PhD studentship in computational genomics of human skin ageing at @KingsCollegeLon i….

Heritability of adipose ACE2 expression levels was 30% in TwinsUK. Despite this heritability and our meta-analysis sample size, we did not identify cis- or trans-eQTLs for adipose ACE2 expression 4/4.

Adipose ACE2 expression was associated with the estimated cell type content of biopsies; positively correlated with proportion of microvascular endothelial cells (known to express ACE2 in other cardiovascular tissues) and negatively correlated with proportion of macrophages 3/4.

Across 3 cohorts (TwinsUK, FUSION, METSIM; N=1,471), lower adipose ACE2 expression levels were associated with adverse cardio-metabolic health indices, including increased obesity, type 2 diabetes, and fasting insulin, and reduced HDL levels 2/4.

Our preprint “ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition”, with @Julia_Moustafa Anne Jackson, Li Guan @SarahBrotman @klmohlke Laura Scott @TwinsUKres 1/4.

King's College London DRIVE-Health is offering 10 PhD studentships in Data-Driven Health (deadline April 19th). Projects 7 and 42 ( are with my group, co-supervised with @DrClaireSteves and @alanjhodgkinson.