
Jeb Keiper
@JebKeiper
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CEO @NimbusTx. A guy (he/him) helping teams discover and develop new medicines for patients. Any tweets are solely my own personal views.
Joined December 2014
I've always enjoyed studying the history of drug R&D, and to share a small snapshot of one perspective on @ldtimmerman's podcast was quite humbling. I submit for your 1.25-1.5x listening pleasure a small piece of the @NimbusTx story (along with some personal early career stories).
Nimbus CEO @jebkeiper joined @Ldtimmerman’s Long Run podcast to share personal insights on the Nimbus story from our computational beginnings 14 years ago, through the Takeda acquisition of our allosteric TYK2 inhibitor, and what our next chapter holds.
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RT @JonahDispatch: America hasn’t been perfect. It’s made grave mistakes. But there is no country that has ever done more for improving the….
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Another great breakdown. One may argue a point here or there but the methodology and approach is fab.
1/ 🧬 How to Price a Platform in Biotech. Q2 M&A is ripping, Capstan just cleared $2.1B at Phase 1, and something important has changed. A new market dynamic may be emerging, where optionality matters again. Let’s break it down with math, comps, and a framework 🧵
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RT @mcuban: No. It's because PBMs corrupt healthcare. Big Pharma wishes they could set their own pricing. They don't. PBMs control formul….
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RT @itsalexvacca: BREAKING: MIT just completed the first brain scan study of ChatGPT users & the results are terrifying. Turns out, AI isn….
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Hype is a bit overblown here. It’s a good build in a rapidly developing field, but structure prediction still doesn’t best AF3 and binding affinity prediction is still inferior to FEP. It is possible to couple those approaches, and for that the team deserves some kudos.
NEW: A trio of young MIT scientists say their new AI model has made progress in predicting binding affinity, a key property in drug discovery. Good affinity prediction has evaded other AI models, but Boltz-2 showed solid improvement: .
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RT @LifeSciVC: Time to get more positive about biotech? @ArthurTzianabos makes the case in a new blog. “We Got This”: Don’t Let Negati….
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RT @matthewstoller: Senator John Kennedy says it's time to break up PBMs instead of mucking around with partial solutions. "I'm all for t….
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RT @mcuban: If you are a CEO of a self insured companies and you want to know what the problem with pricing on medications do this:.Call yo….
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Servants of the US public (which @VPrasadMDMPH you are now) need to stay open to the public. Not block everyone who disagrees, especially someone who does it politely and credibly represents views that deserve dialogue.
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RT @RepAuchincloss: Independent pharmacists are not only trusted medical providers. They are small business owners who are fixtures of Main….
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RT @mcuban: Gotta be honest. The @realDonaldTrump EO on healthcare and in particular, drug pricing could save hundreds of billions. Here….
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RT @RepAuchincloss: Of the eight authors of "Attention is All You Need," the landmark 2017 AI paper from Google, seven are immigrants. The….
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I ❤️ Massachusetts. I ❤️ breakthrough medicines for patients. I ❤️ a strong, competitive biotech industry. I ❤️ insurance reforms that don’t require ridiculous patient out of pockets for drugs. MA can be BOTH competitive & compassionate.
Massachusetts leads the world in biotech—yet its own leaders often criticize the industry that powers the state's economy and develops the new medicines we all depend on. Why?. Over 1,000 companies, 100,000+ jobs, and a mission to save lives. 📺 Watch: The Massachusetts Paradox
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