Miro Plum
@PlumifyM
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Former PhD student @Basler_Lab working on intracellular pathogens - I like tea. Now PostDoc @EPFL in the Persat lab working with cool bacs- I still like tea.
Joined June 2022
The lab's latest NINJ1 story is out on @biorxivpreprint 🥳 Ninjurin-1 mediated plasma membrane rupture is a two-step process requiring cell swelling
biorxiv.org
Plasma membrane rupture (PMR) and the release of cytosolic content are hallmarks of necrotic cell death. The plasma membrane protein ninjurin-1 (NINJ1) actively promotes cell lysis by polymerizing...
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(1/6) Really jazzed to have this out - my first @wellcometrust fellowship paper! https://t.co/uhA1c5Qv0M Can bacteria evolve resistance to competitors' T6SS weaponry? We find that the answer depends on **how many toxins** competitors are using. A thread:
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Out now @biorxiv_micrbio, one of the main publications of my postdoc @Basler_Lab 🥳 more on this soon 😁
Mechanisms of P. aeruginosa resistance to Type VI Secretion System attacks https://t.co/pxoq33OxM5
#biorxiv_micrbio
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🚨🔬Excited to share our new paper now out in @NatureMicrobiol! Using Tn-seq + live imaging in engineered airway organoids, we explored the fitness tradeoffs P. aeruginosa faces while growing and surviving antibiotic treatment on the mucosal surface. 🔗 https://t.co/DCPVogORDv
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Researchers @Biozentrum @UniBasel_en have uncovered a unique tactic certain bacteria use to spread in the body without being detected by the immune system. The bacteria use a kind of nano-sized harpoon. @Basler_Lab
https://t.co/wV2Vvl51rw
unibas.ch
Some pathogens hide inside human cells to enhance their survival. Researchers at the University of Basel, have uncovered a unique tactic certain bacteria use to spread in the body without being...
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If anyone wants to chat about it feel free to shoot me a message. I am always happy to talk about science. Big thanks to @Basler_Lab @yunnhwen @christy_chc non-twitter Patricia, our reviewers and editor.
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🔬 Our paper is live! 🎉Dive into the wild world of Burkholderia's secret tactics – plenty of #T6SS assemblies, actin acrobatics, and some galectin/dynamin inside host cells. We got plenty of images and some cool movies! https://t.co/DRDRUNv7LK
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Snapshot of infection of host cells by Burkholderia thailandensis (white). The pathogen polymerizes actin (green) to move from one host cell to another and breaks the membranes (magenta) by its Type VI Secretion System #T6SS. https://t.co/zpqk4ZOWVk
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Congratulations to Miro (@PlumifyM), Christy (@christy_chc), Patricia and others on a beautiful paper showing #T6SS role in spreading of Burkholderia thailandensis between infected cells: https://t.co/V8WbSv8W5B
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Nice little exhibition at the Biozentrum by @fabi_est_ and @AHarms485 Always surprising to see how diverse Bacteriophages are.
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When you are out of straws but you still got some fermentation equipment at home xD
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