PitarresiPhD
@PitarresiLab
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Jason R. Pitarresi. Father. Studying pancreatic cancer, cellular plasticity/metastasis, and tumor-host interactions. @pitarresilab.bsky.social
Joined February 2021
I'm excited to share the lab’s new paper on PDAC-associated cachexia on bioRxiv today, led by star postdoc @Nikita2106 Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis A 🧵 below, if you're interested... https://t.co/SKsxKkdvog
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Thanks to @UMassChan for writing this piece about postdoc @Nikita2106 in the lab and her recent Rising Star Award from the @NatPancFdn and fellowship award from the Pancreatic Cancer Alliance. Excited to attend the NPF awards gala next week in Boston! https://t.co/xvQMj4srWu
umassmed.edu
Postdoc Nikita Bhalerao, PhD, received the 2025 Rising Star Award from the National Pancreas Foundation and a fellowship from the Pancreatic Cancer Alliance.
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Congrats to Calvin Johnson in the lab for being selected to give a talk at our cancer center retreat. You did a fantastic job!!
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To honor her late mother, PhD candidate @peura_jessica is studying how pancreatic cancer spreads. With an NIH fellowship, she developed a faster, more accurate research model to study metastasis at @UMassChan. #CancerResearch
umassmed.edu
PhD candidate Jessica Peura has earned a prestigious NIH grant to advance her research on pancreatic cancer. After the death of her mother, she’s determined to help prevent families from experiencing...
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Congrats to graduate student @BoyangMa1218 for his poster being chosen for an oral presentation during the last plenary session at #AACRPan25! Thanks to the organizers for giving Boyang this opportunity. He is doing cool work at the interface of CAF, senescence, and RAS biology.
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The largest description of cancer #cachexia to date across all tumor types and over time using data from 60,000 people. @EdReznik redefines what we know about human cachexia integrating genetics, lab values, and treatment lines.
medrxiv.org
Cancer cachexia is a wasting syndrome with outsized impact on morbidity and mortality. Neither the etiology of cachexia, nor its consequences on patient physiology and outcomes, are well-understood....
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Very excited to share this new review on the different EMT tumor states in Nature Reviews Cancer.
It is now know that #EMT is not a simple binary switch but occurs through a series of different tumour states. In this Review, Dong and Blanplain discuss this and the pharmacological implications for targeting EMT to overcome therapy resistance. https://t.co/ZsCo68DkRH
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Congrats to postdoc @Nikita2106 for being awarded an AACR Scholar-in-Training award for this year's #AACRPan25 conference. Be sure to check out her poster # B049 today from 6-9pm!
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Day 2 at #AACRPan25 was a blast! Enjoyed a fantastic lunch with the Ruscetti and Pitarresi lab peeps, followed by an inspiring session at the poster presentations. Bringing home new ideas and connections. Can't wait for Day 3!
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For those attending #AACRPan25, be sure to check out these posters being presented this evening by 3 talented graduate students in our lab @ChaitanyaParik @BoyangMa1218. Thanks to the PCA for supporting their attendance at the conference!
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Congrats Kal! A really beautiful story
Location, location, location! Now out in @NatureCancer, the final version of our study showing how a tumor's anatomic site can impact the function of driver gene mutations, using SMAD4 inactivation in pancreatic cancer as a clin. relevant example: https://t.co/rRu6RYpNWX. (1/3)
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For those attending the Cancer Cachexia Society @CancerCachexia meeting in person who just saw my talk, I know there was no chance for questions for the virtual talks today... but I am happy to connect on here, in the meeting's Whova app, or via email. Please reach out! #FOMO
Excited for my talk tomorrow at the 8th Cancer Cachexia Conference meeting, where I will present our work showing that tumor derived PTHrP is a new driver of pancreatic cancer cachexia. Check out our preprint for the full story: https://t.co/8ba1pFHN7V
@CancerCachexia
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Unfortunately, due to a last minute family medical issue, I will not be able to attend in person but will give my talk virtually and am available on here or via email to discuss our work after!
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Excited for my talk tomorrow at the 8th Cancer Cachexia Conference meeting, where I will present our work showing that tumor derived PTHrP is a new driver of pancreatic cancer cachexia. Check out our preprint for the full story: https://t.co/8ba1pFHN7V
@CancerCachexia
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Congrats to @Marcus_Ruscetti @FitzgeraldKate for their discovery of PPT1 as a new negative regulator of STING in tumor cells! A fantastic study led by postdoc Shreya Chowdhury
In a recent study from our former postdoc Shreya Chowdhury and in collaboration with @FitzgeraldKate, we identified PPT1 as a negative regulator of STING in tumor cells whose targeting could reactivate T cell immunity in ovarian and prostate cancers. https://t.co/xWwQCkLOHy
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A fantastic write-up about grad student Jess Peura's recent NIH F31 award and how she uses her life experiences to motivate her work looking at pancreatic cancer metastasis! Pieces like this remind me how lucky I am to be PI who gets to train the next gen of passionate scientists
PhD candidate Jessica Peura is studying pancreatic cancer in the lab of Jason Pitarresi, PhD, to prevent families like her own from experiencing cancer-related loss. Discover how her @NIH-funded research aims to stop cancer from spreading: https://t.co/tW9QnSZocA
@PitarresiLab
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Full story here: https://t.co/vDO47q90Mg Huge thanks to my collaborators at DFCI, HMS, Broad, UMass Chan, NiKang, and Merck. Couldn’t have done this without you. @kaelin_lab @DrChoueiri @PitarresiLab
biorxiv.org
Kidney cancer frequently causes paraneoplastic syndromes, including hypercalcemia and cachexia, but the underlying mechanisms are incompletely understood. The most common form of kidney cancer, clear...
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Congrats to postdoc @Nikita2106 for winning the Margaret Foti (@AACR_CEO) Scholar-in-Training Award for next month's Pancreatic AACR conference! If you see her at the conference, be sure to ask her about her work on PDAC cachexia, bioRxiv link below! https://t.co/SKsxKkdvog
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I’m thrilled to share that Tony Zhang, a postdoctoral fellow in my lab at the @kochinstitute, has been awarded an early stage K99 award from the NCI/NIH! He is studying how whole-body metabolism drives cancer cachexia. Please join me in congratulating Tony on this honor!
Happy to announce that I was awarded a pathway to independence award (K99) from the NCI/NIH today to work on studying whole-body metabolism driving cancer cachexia. None of this would be possible without support from @DamonRunyon and mentorship from @Transactivator and mvhlab.
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Huge congratulations to Xiling Shen @MDAndersonNews and @AyeletErez @WeizmannScience for their @CellCellPress paper: Vagal blockade of the brain-liver axis deters cancer-associated cachexia https://t.co/ITfwnEI8tR Clinical trials in patients with #PancreaticCancer forthcoming!
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