Philipp Leippe
@PLeippe
Followers
177
Following
944
Media
1
Statuses
81
Biosensor engineer & transporter aficionado. Cyclist, mountaineer and chef in my free time. https://t.co/fWyY43jLh6
Joined March 2019
🔬 Breakthrough in cellular logistics! After a decade of global research, 4 new studies led by Giulio Superti-Furga @ CeMM decode how cells transport chemicals, doubling knowledge on SLCs. ➡️ Read more: https://t.co/5VjkTsNS15 🧬 Open-access tools + data: https://t.co/riA3zjFlqW
1
2
12
„In bedrohlichen Situationen, etwa, als Männer in einer Straßenbahn darüber sprachen, wie sie ihn verprügeln wollten, habe ihm keiner zur Seite gestanden.“ Wir leben in einer Kultur des Wegschauens und brauchen eine Kultur des Hinschauens. https://t.co/at934gcgLN
faz.net
Nach seinem überraschenden Rückzug aus der Politik äußert sich Kevin Kühnert jetzt zu den Gründen. Er habe sich zunehmend bedroht gefühlt, etwa von Coronaleugnern und Neonazis.
620
265
2K
A single injection of a drug, called lenacapavir, protects 96-100 percent of recipients from HIV for up to six months. It's the best HIV preventive ever made. To close out Issue 05, @KLNahas explains how Gilead made it & why getting it to those who need it will not be simple.🔻
3
22
135
X has become an insufferable shithole. Same handle on the other platform!
0
0
0
Cell-Specific Optical Control of AMPA Glutamate Receptors with a Photoswitchable Tethered Antagonist (Dirk Trauner and co-workers) @DonthamsettiLab, @VandyPharm, @Pleippe, @DirkTrauner #OpenAccess
onlinelibrary.wiley.com
AMPA receptors are central to excitatory synaptic transmission in the brain but difficult to control with sufficient precision. We developed MP-GluAblock, a cell specific light-controllable AMPAR...
0
6
28
This is incredibly useful! For me, it's a go-to resource for every SLC project and also invaluable for a systems perspective
Are you curious what is known about SLCs? And how they are related? We are enthusiastic to wrap up the series of four (4) manuscripts by presenting the data- and knowledge-derived functional landscape of human solute carriers #SLC : https://t.co/So4VmaGD34
0
0
1
Happy to share our massive (>1Mio guides) functional genomics study on genetic interactions of SLC transporters by Wolf & Leippe et al.! 🧬 Particularly amazed by how the TCA cycle interactions perfectly mirror known biology! What a journey with the CRISPRator✂️ @wolf_gernot! 🙏
We are thrilled to share the THIRD study of our series which sheds light on the genetic interactions between transporters and links them to the metabolic network: https://t.co/BoNZEJjtM1
1
1
10
Do you want to know with which proteins an SLC membrane transporter socializes? Our @RESOLUTE_IMI series of 4 manuscripts continues, and we are excited to share the so far most comprehensive interactome mapping of solute carriers https://t.co/8WCyD81fbp
1
25
92
We are excited to kick off our series of 4 manuscripts from the RESOLUTE consortium by sharing the metabolic mapping of the Solute Carrier Superfamily ( https://t.co/OAn581qvIN)!
5
87
295
Finally! It is happening! After 6 years of hard work by formidable teams in 13 institutions @RESOLUTE_IMI, we have ordered and validated the results and are able to share the FOUR (4) papers aimed at assigning functional properties to each human SLC #membranetransporter
7
79
389
Thank you for attending the 31st BioOrganik symposium last week in Dortmund, a pre-tenure PI networking conference in the mainly German (bio)organic chemistry sphere, jointly organised with @GalstyanLab @PeterChemBio1 @Wiesenfeldt_Lab @kreidtscience @Johannes_Karges SidneyBecker
4
13
52
Check out our latest work on Tethered Photopharmacology: Cell‐Specific Optical Control of AMPA Glutamate Receptors with a Photoswitchable Tethered Antagonist @PLeippe @IsacoffLab @VandyPharm
0
0
3
Online now! AspSnFR: A genetically encoded biosensor for real-time monitoring of aspartate in live cells by Lars Hellweg, Kai Johnsson, @PLeippe, and colleagues at @EPFL_en @mpi_mr_hd @CeMM_News
https://t.co/5eVAJUVnne
#chembiol
cell.com
Hellweg et al. introduce AspSnFR, a genetically encoded green fluorescent biosensor designed for the real-time measurement of aspartate concentrations in live cells. AspSnFR enables studies of amino...
0
5
13
Especially happy that we were able to detect Ca2+ triggered aspartate export via SLC25A12 from mitochondria in live HCT116 cells. Thanks to everyone involved! https://t.co/we34TQM6Bp 2/2 @mpi_mr_hd @RESOLUTE_IMI @CeMM_News @giuliosf
0
0
9
Very happy and proud to finally see our work on the development the aspartate biosensor AspSnFR published. This was a long and tricky one in the making. The paper is a nice mix of biosensor development and broad applications. 1/2
1
1
19
🚨 @ScienceMagazine paper alert 👉 A novel chemical labeling method allows transient events in cells to be recorded for later analysis. Congrats to @magnus_huppertz and Jonas Wilhelm and their collaboration partners @MPIforBI, @DKFZ and @HHMIJanelia! https://t.co/vJqWIwRFlD
1
15
53
We are out of words... We are grateful to our fantastic speakers, poster presenters, SAB members and participants, that joined us during the last @IHIEurope RESOLUTE conference in #Vienna. We are sure they will #CarryTheTorch for future research on molecular #transporters.
On 27-29 September 2023, the @RESOLUTE_IMI & REsolution Final Conference took place in Vienna 🇦🇹! ~200 participants gathered to listen to top global #SLCs experts, learn more about the project's results & engage in meaningful scientific discussions! ➡️ https://t.co/tmgN5PaCr3
0
10
23
Porty is still an orphan #transporter and he wants to find his #substrate! Let's all help Porty by joining the "Unlocking Transporters for Drugs Discovery" #conference in Vienna.📽️ #scicomm #ScienceTwitter #metabolism @IHIEurope
0
4
7
If you want to hear more about iAspSnFR (and exciting applications), join us for RESOLUTE's glorious closing conference in Vienna (27-29 September) @RESOLUTE_IMI
re-solute.eu
Research Empowerment on Solute Carriers
🎉 Thrilled to share 4 yrs of hard work: iAspSnFR preprint at https://t.co/h1PdrjkUz5 🔬 GFP-based aspartate sensor, engineered via deep mutational scanning, tested in HEK293 cells. Highly specific for intracellular aspartate! #iAspSnFR #biosensor #aspartate
0
3
9
Ever wanted to know what it feels like to be a membrane transporter and be responsible for gatekeeping nutrients and metabolites essential for all biological functions ? JOIN US IN VIENNA for the transporter conference Sept 27-29 https://t.co/mAmynGzAxp
2
13
46