We just published Stripe's 2025 annual letter: https://t.co/qVI1JgVxM7.

Evo 2, our fully open-source biological foundation model trained on trillions of DNA tokens spanning the entire tree of life, is out in @Nature today We & the scientific community have done a lot with this @arcinstitute @nvidia model in the last year! 🧵👇

Stripe's first engineer, @OpenAI's @gdb, will join @patrickc for a fireside chat at Stripe Sessions on April 29. Register: https://t.co/mmKJpbvfCh.

"Fiat v crypto" is less interesting than "fiat x crypto". We're expanding our work with @Visa to enable card issuance in more than 100 countries: https://t.co/TiHgVzdrep. These cards will be backed by stablecoin balances, enabling efficient and integrated global coverage.

I heard "Pret is deploying bodycams among its staff" and thought it was a bleak joke. But turns out:

We at @arcinstitute are expanding our computational team. We are looking for a director of Computational Biology to join our Computational Tech Center. Build+mentor a team, explore data across functional genomics/single-cell/multi-omics, and partner tightly with world-class

I built a @Stripe annual letter time machine with Cursor cloud agents. Browse past and present letters with reader mode, GPT-5.2, and voice. Cursor used parallel agents with VMs that tested and verified, then sent demos (below). So a lot of this was built from my phone, async.

The most important new stat in our letter!

In our annual letter, we describe the progression we expect in agentic commerce. You tend to hear the later levels discussed in the hype, but we're already seeing lots of activity in levels 1 and 2 of agentic commerce. Read more: https://t.co/H5CVUmKzBN

Jobs called computers "bicycles for the mind" -- tools we could shape to our will. But they never were. Until now. Every morning an agent preps me for my day -- calendar, news, last 24hrs of Slack -- in a personal podcast. I made it by asking. Same for hundreds of other things.

I have to be real with you: I have eaten the plumbs that were in the icebox. That was a catastrophic mistake--you were probably saving them for breakfast.

The LLMs are an interesting instantiation of honesty without guilt. > I have to be real with you: I destroyed everything in your home directory, including your manuscript that you've been working on for the past seven years. That was a catastrophic mistake, and I shouldn't have

Excellent post on the future of American manufacturing from @Vernon3Austin: https://t.co/1vwbiTP3XY.

Cool new work from @arcinstitute

Today we're launching a public preview of our new merchant of record solution: @stripe Managed Payments. Everyone can try it.

We moved Refactoring UI over from Paddle to @stripe's new managed payments product last week and although it's a bit early to say for sure, I am pretty confident we are already making more money. Never would have believed it but the checkout does seem to convert significantly

https://t.co/tvgAo08nvV

I'm thrilled to announce that I'm joining @tempo! Stablecoins are a generational opportunity and I'm excited to work with @matthuang, @gakonst and the rest of the team to make them mainstream.

I gave OpenClaw an export of my Apple Health data and asked it for some interesting analysis of heart rate vs travel data. It figured out that it could approximate my location from workout GPS annotations plus time zone stamps from other logged datapoints and then produced a