SijbrenOttoLab
@OttoLab
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Systems Chemistry Group at the University of Groningen. Transition of chemistry to biology (incl. origins of life, synthetic life), complex systems.
Groningen, The Netherlands
Joined February 2013
Selection for photocatalytic function through Darwinian evolution of synthetic self-replicators https://t.co/2P5ugAr5zh
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How to select primitive / synthetic replicators based their photocatalysis? Check out our manuscript just published in @NatureCatalysis : https://t.co/N9BJYoKkJj
@KaiLiu125348 @Ottolab
#OoL #Origins #Prebiotic #Evolution
nature.com
Nature Catalysis - Darwinian evolution has shaped life on our planet through natural selection. Here, the authors report on the combination of self-replication, mutation and protometabolism in an...
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Light-Mediated Interconversion between a Foldamer and a Self-Replicator | Journal of the American Chemical Society @LMU_Muenchen
@StratinghInst
@univgroningen
#Foldamer #SelfReplicator #LightMediated #Interconversion
pubs.acs.org
Self-replicating molecules and well-defined folded macromolecules are of great significance in the emergence and evolution of life. How they may interconnect and affect each other remains largely...
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Simultaneous Formation of a Foldamer and a Self-Replicator by Out-of-Equilibrium Dynamic Covalent Chemistry | JACS @LMU_Muenchen @StratinghInst @univgroningen #Foldamer #SelfReplicator #OutofEquilibrium #Dynamic #Covalent #Chemistry
pubs.acs.org
Systems chemistry has emerged as a useful paradigm to access structures and phenomena typically exhibited by living systems, including complex molecular systems such as self-replicators and foldame...
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What can dissipative chemistry bring us? In our recently published paper, we demonstrate the emergence of mechanical function from disspative droplet systems. @NatureChemistry
nature.com
Nature Chemistry - The use of molecules as fuels to achieve function is largely unexplored. Now it has been shown that fuelled dissipative self-assembly can yield transient droplets that release a...
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Probe the non-enzymatic macrocyclization reaction of benzene-1,3-dithiol in the presence of peptide condensates by reactive Martini simulations, reported by @CG_Martini @OttoLab @csbrasnett
https://t.co/Xtkyb3MXJO
nature.com
Communications Chemistry - Biomolecular condensates show distinct physicochemical properties that may affect the rate of enzymatic activity and control cellular redox reactions, however, their...
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A little peak into last year's work with @Juntian74804617 and @Armin__Kiani in @OttoLab . You think our replicators are already complex enough? Then brace yourselves, Marcel has put 2-3 of them in competition and we had to make sense of their behaviour... https://t.co/alj4wARR41
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This study introduces a new mechanism that decreases error rates and corrects errors in synthetic self-replicating systems driven by self-assembly. @angew_chem #chemistry #Science #chemed #Technology #news @OttoLab @OmerMarkovitch
https://t.co/qPPaJ7ntDn
Binding of Precursors to Replicator Assemblies Can Improve Replication Fidelity and Mediate Error Correction (Sijbren Otto and co-workers) #openaccess @OttoLab @OmerMarkovitch
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Generalist versus Specialist Self-Replicators (Sijbren Otto and co-workers) @seilenfranzli @Nitrogeno_N @GuilleMonrealS @OttoLab @StratinghInst
chemistry-europe.onlinelibrary.wiley.com
Whether assembly-driven self-replicators that emerge from a mixture of two building blocks specialize on one resource or are generalists was found to depend on their supramolecular organization.
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Binding of Precursors to Replicator Assemblies Can Improve Replication Fidelity and Mediate Error Correction (Sijbren Otto and co-workers) #openaccess @OttoLab @OmerMarkovitch
onlinelibrary.wiley.com
Binding of precursor molecules to the side of a fibrous assembly of self-replicating macrocycles can improve the fidelity of replication and yield a novel error-correction mechanism, provided that...
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Our newest paper is out!!! Here we show how a replicator system can correct errors during replication. Congrats @OmerMarkovitch and @Juntian74804617 🥳 Check it out: https://t.co/hk4nm6XcmZ
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Fancy doing some shiny new chemistry in a shiny new building? If so, come and join us @UoBChemistry 😀 We have fully funded PhD positions available working on…
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Sijbren and Kayleigh were interviewed by @NEMOkennislink at the occasion of the 70th birthday of the famous Miller-Urey experiment. Check it out if you speak Dutch - or know how to use Google translate!
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We have a PhD position on phosphate-driven non-equilibrium assemblies @ERC_Research funded at @FitFreiburg @UniFreiburg. Deadline for application is 15/01/24. More information can be found here: https://t.co/0nwizkD0mW RT appreciated!
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Can a purely chemical system reduces its #errors during #replication? And even "correct" them?. In this latest @ChemRxiv we are claiming YES to both questions! https://t.co/PA7qqcJdhx
@OttoLab @Juntian74804617
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The University of Padova (@UniPadova) has opened the selection procedure for talented students from China that want to pursue a PhD in Italy with a CSC-scholarship. For those interested in working in my group ( https://t.co/5ZTcLPQsD6), please contact me via email. RT appreciated
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More details about the proposal on the university website👇 https://t.co/MYvmEUShT3
rug.nl
Sijbren Otto awarded an ERC Synergy Grant
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More PhD and also post-doc positions will open - especially prospective post-docs are encouraged to get in touch with Sijbren soon. We offer high-quality research in a multidisciplinary field and (soon) in a brand-new building in Groningen!
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BREAKING💥Ottogroup was awarded an ERC synergy grant, together with @AshkenasyLab and the groups of Eörs Szathmáry and Andrew Griffiths. Greatest thanks to all collaborators, it was a long and winding journey but it paid off!
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Please spread the word! We look for excellent students with motivation to work in an interdisciplinary environment. Potential candidates should directly get in touch with Sijbren:
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