Ed Needham
@NeedhamNeuro
Followers
389
Following
641
Media
17
Statuses
1K
Neurologist treating and researching neuroimmunology & neurocritical care; worser-half of @drzoeneedham
Cambridge, England
Joined July 2014
How to Read an #EEG strikes back -- Now covering "#Epileptiform Abnormalities"! ⚡️🧠 @KNascimenski @SBeniczky @DrHirschEEG
https://t.co/69CecWqrwd
2
100
349
A small 🧵 encouraging people to publish protocols. Our #AutoSpectral release has made me reflect on how much the community tends to appreciate protocol papers. People rarely present protocols as their main work, but they are often the most impactful https://t.co/BG3DVIMySZ
biorxiv.org
The advent of spectral flow cytometry has seen a rapid rise in the complexity of flow cytometry experiments, allowing the construction of assays with at least 50 fluorescent parameters. To correctly...
2
8
49
Pre-print alert! And this one really is a must read for anyone that does spectral flow cytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? https://t.co/BG3DVIM13r
8
53
234
I attended a Ska/2 Tone revival concert yesterday. This morning, and thinking about it, I find it depressing how the movement's essential message is still relevant and still needed. Great band, though.
0
2
9
Just had my first piece for @bmj_latest Opinion published. Thanks to @dr_mattmorgan for the encouragement. Hopefully it’ll resonate with EM colleagues. https://t.co/r4biuGZ4N1
bmj.com
We need a culture shift from defensive practice to clinical courage, writes Iain Beardsell Emergency medicine in the UK and across the world is in trouble. This is not news, I know. We’re overwhelmed...
3
20
35
This study highlights the complexity and diversity of the AChR autoantibody repertoire, suggesting its potential impact on responses to treatments among patients with myasthenia gravis: https://t.co/B3Y137Jdif
#NeuroX #NeuroTwitter
0
7
27
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: https://t.co/lfhJyTUXKg
currentprotocols.onlinelibrary.wiley.com
Recent advances in dyes and cytometers have seen an exponential increase in the ability to perform multidimensional flow cytometry. As we increase our capacity to extract information from cells, the...
5
32
149
Inspiring first day at TBI-REPORTER General Assembly. A photo of all participants and delegates who’ve contributed to the discussions today. #UKABIF #TBI #REDCap #cognitron #aquiredbraininjury
1
3
3
Many congratulations to Michael Baker on putting together this detailed analysis of metabolic abnormalities after moderate-severe Traumatic Brain Injury incorporating ICP, MD and autoregulatory indices @_SaraVenturini_ @pja_hutch
journals.plos.org
Objective We aimed to compare the prevalence and multimodal associations of mitochondrial dysfunction as defined by published cerebral-microdialysis-based criteria versus our novel multimodality-mo...
0
1
1
We are pleased to announce the launch of a new taught MPhil programme in Brain Health and Disease: Clinical Neurosciences at the University of Cambridge. We are currently seeking a Course Coordinator to support this new programme. Please see: https://t.co/82p4Zm0bbu
0
2
2
Othman et al. studied the impact of apomorphine and methylphenidate on consciousness biomarkers and clinical arousal in ICU patients with brain injury, in a randomized placebo-controlled trial. https://t.co/BWR0FNiMvF
0
3
16
Passionate about neuroimaging and data science? Join the @TBI_REPORTER as a Postdoctoral Research Associate in Image Analysis. You'll work with scientists, clinicians & industry partners globally to develop and execute imaging analysis pipelines. APPLY: https://t.co/q9NKMr45Mh
0
3
5
Beware commercial tissue based assays (TBAs) to detect cell surface autoantibodies in neurology. TBAs are often used as screening tests and are reader dependent. Bottom line: please think clinically when diagnosing autoimmune neurological syndromes https://t.co/l1Dptb28Tl
pubmed.ncbi.nlm.nih.gov
The diagnostic performance of EUROIMMUN IIF-TBA in detecting NSAbs in autoimmune encephalitis is suboptimal. NMDAR antibodies, among the most common NSAbs, can be missed in 50% of cases. This...
1
8
35
and how dysfunctional meningeal lymphatics regulate synaptic physiology in a microglia-dependent manner https://t.co/AZ4eOJXd4c
cell.com
Dysfunctional meningeal lymphatics interfere with the inhibitory synaptic inputs and disrupt excitatory/inhibitory balance on cortical neurons in a microglia-IL-6-dependent manner. Enhancing the...
0
5
13
Implementation of 2HELPS2B Seizure Risk Score: A Cost-Effective Approach to Seizure Detection in the Intensive Care Units https://t.co/VNIr7pFLto
1
6
29
#CASPR2-#antibody diseases are provide clues to mechanisms of autoantigen-specific tolerance Here - in @ScienceAdvances - we show how central and peripheral B cell tolerance licences pathogenic CASPR2 antibody generation. https://t.co/lmXB9fcHBy More below 👇🏿
science.org
Central and peripheral tolerance thresholds that license CASPR2-antibody diseases are identified.
3
18
52
Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 @NatureNeuro
nature.com
Nature Neuroscience - The authors show that brain inflammation in COVID-19 correlates with viral load, systemic inflammation and virus-sensing pattern recognition receptors. Microglial dysfunction...
3
33
135
A huge privilege to participate in the @ARUKscientist debate, discussing hope for future treatments for devastating dementias but also practical barriers to delivering current therapies both in NHS @CPFT_NHS and privately @spirehealthcare that need to be overcome for a true cure
🔥 Burning debate incoming! Expect a lively discussion on the most pressing issues in dementia research. What’s your take on today’s big topics? #ARUKConf25
0
5
16
About half of patients with NPH and parkinsonism have an abnormal DaT SPECT, but they do not have nigrosomal loss like in PD! Is their parkinsonism from mechanical disruption rather than neurodegeneration? Check out this cool study! https://t.co/bQfUXkJLjJ
5
11
59