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Ed Needham Profile
Ed Needham

@NeedhamNeuro

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Neurologist treating and researching neuroimmunology & neurocritical care; worser-half of @drzoeneedham

Cambridge, England
Joined July 2014
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@fabnascimen
Fábio Nascimento
1 month
How to Read an #EEG strikes back -- Now covering "#Epileptiform Abnormalities"! ⚡️🧠 @KNascimenski @SBeniczky @DrHirschEEG https://t.co/69CecWqrwd
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@LabListon
Adrian Liston
1 month
A small 🧵 encouraging people to publish protocols. Our #AutoSpectral release has made me reflect on how much the community tends to appreciate protocol papers. People rarely present protocols as their main work, but they are often the most impactful https://t.co/BG3DVIMySZ
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biorxiv.org
The advent of spectral flow cytometry has seen a rapid rise in the complexity of flow cytometry experiments, allowing the construction of assays with at least 50 fluorescent parameters. To correctly...
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@LabListon
Adrian Liston
1 month
Pre-print alert! And this one really is a must read for anyone that does spectral flow cytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? https://t.co/BG3DVIM13r
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@CaptainSwing666
CaptainSwing666 🇪🇺
2 months
I attended a Ska/2 Tone revival concert yesterday. This morning, and thinking about it, I find it depressing how the movement's essential message is still relevant and still needed. Great band, though.
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@GreenJournal
Neurology Journal
2 months
This study highlights the complexity and diversity of the AChR autoantibody repertoire, suggesting its potential impact on responses to treatments among patients with myasthenia gravis: https://t.co/B3Y137Jdif #NeuroX #NeuroTwitter
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@LabListon
Adrian Liston
3 months
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: https://t.co/lfhJyTUXKg
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currentprotocols.onlinelibrary.wiley.com
Recent advances in dyes and cytometers have seen an exponential increase in the ability to perform multidimensional flow cytometry. As we increase our capacity to extract information from cells, the...
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@TBI_REPORTER
TBI-REPORTER
3 months
Inspiring first day at TBI-REPORTER General Assembly. A photo of all participants and delegates who’ve contributed to the discussions today. #UKABIF #TBI #REDCap #cognitron #aquiredbraininjury
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@AdelHelmy79
Adel Helmy
3 months
Many congratulations to Michael Baker on putting together this detailed analysis of metabolic abnormalities after moderate-severe Traumatic Brain Injury incorporating ICP, MD and autoregulatory indices @_SaraVenturini_ @pja_hutch
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journals.plos.org
Objective We aimed to compare the prevalence and multimodal associations of mitochondrial dysfunction as defined by published cerebral-microdialysis-based criteria versus our novel multimodality-mo...
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@estamatakis
Emmanuel A Stamatakis
4 months
We are pleased to announce the launch of a new taught MPhil programme in Brain Health and Disease: Clinical Neurosciences at the University of Cambridge. We are currently seeking a Course Coordinator to support this new programme. Please see: https://t.co/82p4Zm0bbu
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@Brain1878
Brain
5 months
Othman et al. studied the impact of apomorphine and methylphenidate on consciousness biomarkers and clinical arousal in ICU patients with brain injury, in a randomized placebo-controlled trial. https://t.co/BWR0FNiMvF
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@MedCambridge
Medicine at Cambridge
6 months
Passionate about neuroimaging and data science? Join the @TBI_REPORTER as a Postdoctoral Research Associate in Image Analysis. You'll work with scientists, clinicians & industry partners globally to develop and execute imaging analysis pipelines. APPLY: https://t.co/q9NKMr45Mh
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@Mayo_AING
Mayo Florida AutoImmune Neurology Group
7 months
Beware commercial tissue based assays (TBAs) to detect cell surface autoantibodies in neurology. TBAs are often used as screening tests and are reader dependent. Bottom line: please think clinically when diagnosing autoimmune neurological syndromes https://t.co/l1Dptb28Tl
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pubmed.ncbi.nlm.nih.gov
The diagnostic performance of EUROIMMUN IIF-TBA in detecting NSAbs in autoimmune encephalitis is suboptimal. NMDAR antibodies, among the most common NSAbs, can be missed in 50% of cases. This...
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@NeurologyCP
Neurology: Clinical Practice
7 months
Implementation of 2HELPS2B Seizure Risk Score: A Cost-Effective Approach to Seizure Detection in the Intensive Care Units https://t.co/VNIr7pFLto
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@Mayo_AING
Mayo Florida AutoImmune Neurology Group
8 months
#CASPR2-#antibody diseases are provide clues to mechanisms of autoantigen-specific tolerance Here - in @ScienceAdvances - we show how central and peripheral B cell tolerance licences pathogenic CASPR2 antibody generation. https://t.co/lmXB9fcHBy More below 👇🏿
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science.org
Central and peripheral tolerance thresholds that license CASPR2-antibody diseases are identified.
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@LukensJohnR
John Lukens
9 months
Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 @NatureNeuro
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nature.com
Nature Neuroscience - The authors show that brain inflammation in COVID-19 correlates with viral load, systemic inflammation and virus-sensing pattern recognition receptors. Microglial dysfunction...
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@tccambs
Thomas Cope
9 months
A huge privilege to participate in the @ARUKscientist debate, discussing hope for future treatments for devastating dementias but also practical barriers to delivering current therapies both in NHS @CPFT_NHS and privately @spirehealthcare that need to be overcome for a true cure
@ARUKscientist
Research at ARUK
9 months
🔥 Burning debate incoming! Expect a lively discussion on the most pressing issues in dementia research. What’s your take on today’s big topics? #ARUKConf25
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@EnriqueZenitram
Enrique Martinez
10 months
About half of patients with NPH and parkinsonism have an abnormal DaT SPECT, but they do not have nigrosomal loss like in PD! Is their parkinsonism from mechanical disruption rather than neurodegeneration? Check out this cool study! https://t.co/bQfUXkJLjJ
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