I was delighted to be asked to write for Practical Neurology on treating and depression in people with epilepsy. Hopefully useful, practical advice to help all neurologists feel confident that this is within their competence: With @eosimo and @PaulPcf22.

I am pleased @guardian showed the King's delight at our study of parallel transmit 7T MRI in Epilepsy. I am similarly delighted that it enabled a third of patients with negative conventional imaging to be offered a curative surgical treatment

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A huge privilege to participate in the @ARUKscientist debate, discussing hope for future treatments for devastating dementias but also practical barriers to delivering current therapies both in NHS @CPFT_NHS and privately @spirehealthcare that need to be overcome for a true cure.

Patients with epilepsy often complain bitterly about poor memory, but what can we say about how different types of memory are affected by different types of epilepsy? Kirsty Phillips' excellent review will be core reading for clinicians and neuroscientists

What does it look like to lose your understanding of the world? Drawings from patients with semantic dementia reveal a transmodal graded loss of concept knowledge: with @CambridgeFTD.

RT @le_Tomassini: Thrilled to share my latest paper, a culmination from my prior career chapter. Special thanks to my fellow co-authors @….

RT @CamNeuro: 📢 CNS2024: Sleep, Consciousness & Cognition is live and open for registration.🌍Queens' College | April 5th 2024.🌟Incredible l….

I am extremely grateful to the patients, their families, and the healthy volunteers . To my collaborators, including @DrMattDavis @MasudHusain @AuditoryGroup @chrisrbutler @CambridgeFTD and others. And to the funders who made it possible, especially @acmedsci @theABN_Info.

Overall, we propose a tripartite speech perception network in which inferior frontal gyrus supports prediction reconciliation in echoic memory, and precentral gyrus invokes a motor model to instantiate and refine perceptual predictions for speech.

We showed that frontal neurodegeneration impairs the integration of speech predictions with sensory input in the ‘mind’s ear’ – echoic memory regions of anterior superior temporal gyrus.

We showed that a different frontal brain region, Left Inferior frontal gyrus ("Broca’s area"), represents verified and violated predictions independently. This is a significant change in the way we understand how the brain reconciles prediction with sensory input.

Weighted prediction error is a new concept that quantifies how much information the error contains about how predictions could be better next time. This is similar to precision weighting, but is based on the informativeness of a single trial, rather than long-run uncertainties.

We showed that the brain regions that control mouth motor movements (Left Precentral gyrus) not only represented the patterns of sounds in spoken words (phonology), but also represented weighted prediction error.

We used advanced brain imaging (7T fMRI) to decode the neural patterns of written predictions and spoken words. We compared these patterns when the written and spoken words matched (a verified prediction) and when they did not (a violated prediction).

Over four years we collaborated to recruit patients with a very rare illness called non-fluent variant primary progressive aphasia (nfvPPA), which is caused by selective neurodegeneration of frontal lobe language regions, but without damage to temporal lobe auditory regions.

I am delighted to share a major collaborative study between Cambridge, Oxford, London and Newcastle that has really changed my understanding of how the brain predicts and perceives speech, and how this can go wrong in non-fluent aphasia [a thread].

The fantastic @ProfRobHoward again highlighting something I hadn't considered. The potential for infusion reactions unblinding patients and relatives during the lecanemab trial, perhaps contributing to very small clinical effects. @The_BNPA fantastic conference.

RT @M_Malpetti: Our work on synaptic PET in FTD is online on @ANA_journals - I couldn't be prouder of the wonderful teamwork (during a pand….

Thank you to @mrccbu for hosting the research, to @CambridgeFTD for making it all possible by recruiting patients over many years, and to my collaborators Laura Hughes, Tallie Adams, @MoatazAssem, @AlexWoolgar, John Duncan and many others, who made this work better.

This in turn helps us to explain the problem in clinic, to emphasise the importance of signposting changes and providing extra time to deal with new situations.