MyungHyun.Jo
@MyunghyunJ
Followers
78
Following
55
Media
1
Statuses
39
Biophysicist, single-molecules to living cells We moved to Boston Children's Hospital / Harvard Medical School
Boston, MA
Joined February 2020
Our research was published today in science!.We developed single-molecule tension sensors based on DNA overstretching and measured the rate of cellular force increase using these sensors.
Determination of single-molecule loading rate during mechanotransduction in cell adhesion | Science
1
6
12
RT @t_n_kohler: Congratulations to the two GRS signaling by adhesion receptor best talk winners @MilanRCollins and @MyunghyunJ as well as….
0
8
0
RT @naturemethods: Research Highlight by.@rita_strack.:.TJ Ha @taekjip, Myung Hyun Jo, and colleagues develop a single-molecule method for….
0
6
0
RT @LaskerFDN: Cells connect with their environment through surface receptors and use physical tension to regulate cellular processes. A ne….
0
15
0
RT @taekjip: Determination of single-molecule loading rate during mechanotransduction in cell adhesion | Science
science.org
Single-molecular tension sensors reveal cellular force loading rate during mechanotransduction.
0
38
0
RT @Hypothesisfund: TJ’s cutting-edge research “is based on the idea that DNA mutations can act directly through DNA physics, such as benda….
0
3
0
The Institute for Protein Innovation (IPI) introduces our recent work. Uncovering the secrets of mechanotransduction, one integrin receptor at a time.
proteininnovation.org
For the body to function, cells must decide. Embryonic cells elect to reproduce and shape into budding limbs. Immune cells choose to leave the bloodstream
0
0
9
RT @ZhixingChen2: The Cys-conjugated Cy dyes are always more prone to photobleaching than those labeled through amide bonds. Why? .Working….
0
22
0
The cell shape, or cytoskeletal structure, is thus not predetermined by cell type, but is highly regulatable by the type of ligand outside the cell.
0
0
1
Integrin proteins mediate cell-cell or cell-ECM interactions. Here we show that two subtypes of integrin (RGD-binding and LDVP binding integrins) employ dramatically different mechanotransduction mechanisms for cell spreading.
0
0
1
My third paper in Johns Hopkins just came out. Single-molecule characterization of subtype-specific β1 integrin mechanics.Nat Commun 13, 7471 (2022).
nature.com
Nature Communications - Integrins come in subtypes that bind distinct ligands. This work reveals and quantifies subtype-specific mechanical force transmission and assembly of cytoskeleton...
7
20
74
0
2
0
RT @GronlohMax: And it’s online, I’m very proud to share that our paper on neutrophil transendothelial migration hotspots can be found onli….
0
34
0
RT @joachimgoedhart: I like timelines a lot. Here's a timeline of 60 years of GFP discovery and engineering, made for @focalplane_jcs: http….
0
122
0
Here we show that neutrophils sense the level of fluid drag transduced through individual β2-integrin bonds, providing an intrinsic means to modulate inflammatory response in the microcirculation.
0
0
6
RT @taekjip: Yun Chen of MechE Hopkins led this work in Nature Physics. How membrane ruffling senses solution viscosity. Biophysical modeli….
nature.com
Nature Physics - Living cells change their behaviour in response to the viscosity of the medium surrounding them. An in vitro study shows that cells spread wider and move faster in a highly viscous...
0
7
0