Dave
@MrDavidHourigan
Followers
526
Following
4K
Media
6
Statuses
546
PhD. Postdoctoral researcher at @Pharmabiotic. Microbes to Molecules. President of @ISAPPSFA. Part time renaissance man. @LFC fan. Views expressed are my own.
Cork / Dungarvan
Joined November 2010
proGenomes4: providing 2 million accurately and consistently annotated high-quality prokaryotic genomes | Nucleic Acids Research | Oxford Academic
academic.oup.com
Abstract. The pervasive availability of publicly available microbial genomes has opened many new avenues for microbiology research, yet it also demands rob
0
3
3
Meet the Ankylosaurus: nature’s original phage-resistant strain. 🦖🧬
0
3
18
The 2026 Gregor Reid Award for Outstanding Scholars in Developing Nations is open for applications! 🏆 Deadline: November 14th, 2025. https://t.co/rA7XPxLf2A
0
2
3
Proud to present a new preprint from our lab https://t.co/qA0iDmyQ4M
@Isala_UAntwerp : deep dive into mechanisms of vaginal lactobacilli-host interactions by @carolinedricot & @denisedelgato - lots of collabs!
biorxiv.org
The human vaginal microbiome, particularly with lactobacilli as the main inhabitants, plays a key role in maintaining women’s health. While lactic acid-mediated pathogen exclusion is well known,...
0
1
4
New paper alert! 🚨Work led by Jan Franzen from Horst Posthaus' lab, who spent some time in our group. Amazing collection of C. perfringens isolates, 220 new @PacBio genomes + analyses.
microbiologyresearch.org
0
1
2
In this month’s ISAPP SFA blog, PhD student Anik Khan shares his work with the EU-funded DOMINO project. His synthetic ecology approach can be used to transform by-products like fruit pulp into nutritious, plant-based fermented foods 🌱 Read more 👇 https://t.co/IWV0jLOoCk
0
3
11
Isolation, engineering and ecology of temperate phages from the human gut | Nature
nature.com
Nature - Human host-associated cellular products may act as induction agents for bacteriophages.
1
6
23
QUESTION: When you think of someone who's inspired you & had a significant impact on the field of probiotics, prebiotics, synbiotics, postbiotics and fermented foods, who do you think of? Consider nominating them for the 2026 Sanders Award! Details here: https://t.co/gFdNchlv02
isappscience.org
In 2023, the ISAPP board of directors launched the Sanders Award for Advancing Biotic Science to mark the retirement of ISAPP’s longtime Executive Director,
0
3
7
Serine recombinases are conserved genetic markers of antiphage defense systems https://t.co/N5YsfdzG55
#biorxiv_micrbio
biorxiv.org
Antiphage defense systems confer bacteriophage (phage) resistance in bacteria. Renewed interest in phage therapy indicates a need to understand the breadth and molecular mechanisms of antiphage...
0
8
17
Out Now! How nutrient starvation impacts the gut microbiome https://t.co/ZA4vzp089y
#GutMicrobiome #NutrientStarvation #Microbiology
1
47
132
In our latest ISAPP-SFA blog, David Alvarado shares how setbacks, mentorship & connection at his first ISAPP meeting shaped his path in research. His honest take shows us that persistence, not perfection, drives science! Read the full blog now 👇 https://t.co/NfXsjiGum0
0
4
6
Some amazing talks at @APCPostdoc symposium today! Here is @MrDavidHourigan sharing insights into Nisin genes distribution across microbiomes
0
2
3
@MrDavidHourigan et al. find widespread #nisin-like core peptides prevalent on mobile genetic elements with evidence of horizontal transfer between #Streptococcus, #Enterococcus and #Staphylococcus. https://t.co/j9dWR5cygY
#bacteriocin #microbiome
1
7
7
We heterologously express 5 novel nisin variants and show that they have antimicrobial activity. One of these is naturally produced by the pig gut anaerobe Velocimicrobium porci.
0
0
0
A significant fraction (~30%) of these gene clusters appear to be associated with mobile genetic elements. Which means they’re not fixed and can travel between bacterial species.
1
0
0
Nisin is a bacteriocin and food preservative with antimicrobial properties. We highlight that the genetic capacity to produce nisin is more widespread than previously anticipated.
1
0
0
Delighted to have this piece of work published in mBio: "Nisin-like biosynthetic gene clusters are widely distributed across microbiomes". @Pharmabiotic @mbiojournal @ASMicrobiology @UccMicrobiology
https://t.co/30wRPtUxMn
journals.asm.org
Our research reveals the heretofore underappreciated presence of diverse and widespread nisin-like biosynthetic gene clusters in microbiomes across the globe. Notably, different clusters share...
1
3
4
Big congrats to Dr. David Woods, Technical Officer @UccMicrobiology, on successfully defending his PhD! Thanks to supervisors @JenniferMahony7, @JerryReen_UCC, internal examiner @PaulineScanlan, chair Dr. Supratik Roy, & external examiners @AndreasKaraj & Paudie Murray(TUS)
1
3
13
First time attending the @esnm_eu conference - what a fantastic meeting! #Neurogastro2025 Many thanks to @ISAPPscience and @esnm_eu for the invitation to present our @Nature Microbiology review ( https://t.co/idPJ1lP6zE), led by @ProfWhelan and Maria Marco.
0
6
19
ISAPP was pleased to hold a joint symposium with @esnm_eu addressing the question: "Is gut health a meaningful concept in neurogastroenterology?" https://t.co/bqfWLLbwoj Stay tuned for our gut health definition paper, to be published soon!
0
6
14