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Wiep Klaas Smits Profile
Wiep Klaas Smits

@SmitsLab

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Assoc. prof. @LUMC_Leiden/CMAT. Cdiff, DNA replication, AMR, microbiome, anaerobes. Clostpath SC. Education officer ESGCD. Also: @smitslab.bsky.social

Leiden, Nederland
Joined August 2015
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
2 months
Important: if a bug does not make the WHO's priority list, this does not mean it is not relevant. We present arguments why investment in R&D for surveillance, control and treatment of C. difficile (CDI) is of critical importance:
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
20 hours
Host origin of microbiota drives functional recovery and Clostridioides difficile clearance in mice | mBio
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
2 days
RT @JessicaMABlair: If anyone needs a clear explanation of how to do standardised antibiotic susceptibility testing (MICs) properly then I….
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
10 days
Environmental microbiomes drive chemotactile sensation in octopus
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
12 days
Full article: Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
12 days
Flagellar switch inverted repeats impact heterogeneity in flagellar gene expression and thus C. difficile RT027/MLST1 virulence
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
12 days
Phenotypic analysis of various Clostridioides difficile ribotypes reveals consistency among core processes | Applied and Environmental Microbiology
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
12 days
Genomic Characterization of Linezolid-Resistant Clostridioides difficile Harboring cfr Variants.
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
12 days
Novel integrative and conjugative elements carrying cfr(B) and cfr(C) linezolid resistance genes in Clostridioides difficile isolates from calves, Italy
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
16 days
Great to work with a diverse group of co-authors: @TheGareyLab @RupnikMaja @a2binny @PeggyFund #ESGCD (@ESCMID) @AnaerobeSociety @YipingHan1 and others.
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
16 days
Paper alert: Proud that we brought together researchers, clinicians and patient/carers to convey our point that it is important to bring novel treatments for bacterial pathogens to patients also if they are not on the WHO Bacterial Priority Pathogen list.
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
16 days
Defining the minimal structural requirements of DivIVA in filamentous Actinomycetota - by the lab of @ClaessenLAB.
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
16 days
Tumbleweed: an artificial motor protein that walks along a DNA track -
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
16 days
Cell cycle dysregulation of globally important SAR11 bacteria resulting from environmental perturbation
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
17 days
A deoxynucleoside triphosphate triphosphohydrolase promotes cell cycle progression in Caulobacter crescentus | Journal of Bacteriology
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
17 days
RT @EricTopol: This is wild! .Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol) .@NatureChemistry . https://t.co….
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
17 days
Paper alert ❗️Mass spectrometric analysis of lipid-linked oligosaccharide heterogeneity in genetically modified E. coli used for glycoconjugate bacterial vaccine production - led by our colleagues at CPM @LUMC_Leiden with @JNJInnovMedNED.
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
18 days
Cyclic-di-AMP modulates cellular turgor in response to defects in bacterial cell wall synthesis -
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
28 days
RT @nonresidentdesi: Thrilled to share our new paper in @ScienceMagazine! We found that when bacteria can’t digest available nutrients—but….
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
1 month
The dark matter of bacterial genomic surveillance—antimicrobial resistance plasmid transmissions in the hospital setting | Journal of Clinical Microbiology
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@SmitsLab
Wiep Klaas Smits
@SmitsLab
1 month
RT @biorxiv_micrbio: Analysis of Essential Genes in Clostridioides difficile by CRISPRi and Tn-seq #biorxiv_micrbio.
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