My yearly reminder to all founders as you go build that next Google/MSFT/Salesforce killer app in 2026: when distribution is proprietary, distribution wins (Comcast vs Netflix), when distribution is commoditized, best product wins (chrome vs IE), when product is commoditized,

Yearly renewals are the time of the year where SAAS companies play "Dormammu, I've Come To Bargain" with their clients while disagreeing which one of them is Dr. Strange. 🪄

@TruthBrosHQ Doesn’t have to be significant but a few examples that are signs but people consider normal: - hangovers are much worse - number of people wearing glasses is growing in that age group - medicine use increases - and well mortality increases with age roughly 1.5-2x higher in the

What life is like for the algorithm team

It's hard to oversell how big a discovery this is. Heart disease is America's #1 cause of death. With a combination of two drugs administered once every six months, it might be mostly defeated. Just think about that how big this is! You will know your great-grandkids!

Me: Maybe you should try being happy? Everyone: How dare you tell me to not be angry all the time

A longer life for billions, not billionaires. The promise of aging science is not to increase the lifespan of a wealthy few, but to allow billions of people worldwide to live longer, healthier lives.

i’m low-key sick of people asking me why I’m interested in solving aging, as if I need a special reason to want to work on the thing that kills 80% of people (including you, your family, oh and your dog too) it’s the people who don’t want to solve aging who are the weirdos.

Guy in one of my groups at a conference just absolutely rawdogged a meeting. No notepad, iPad or laptop. First name basis the with the c-suite. Sharpest questions in the group. Incredible stuff.

Blame yourself for everything, and preserve your agency.

New Anthropic Research: “Inverse Scaling in Test-Time Compute” We found cases where longer reasoning leads to lower accuracy. Our findings suggest that naïve scaling of test-time compute may inadvertently reinforce problematic reasoning patterns. 🧵

@LateToDinner00 OP’s post claims that people aren’t having kids due to economic uncertainty. I’m refuting this by pointing out that even those with economic certainty are having kids at lower rates. Therefore economic uncertainty cannot explain it all.

A gentle reminder. From ideology.

startup bingo 😅

Me: I wonder why they have a bad rating. Maybe people just hate on bureaucracy related apps. App: crashes and loses all data I've entered for the past five minutes.

🇳🇱 On my way to Amsterdam to host a product leadership panel with @Product__People & @Adyen this evening.

b2b is understanding budgets. b2c is understanding behavior.

Nice try @readwise! one email per month would have worked better for me as an option 😁

My account doesn’t show up on the Polytopia global leaderboard. @Midjiwan is it because I got the score playing Perfection against the bots and not in multiplayer mode? 🥲

Agree this is becoming a basic expectation like knowing how to use a calendar and spellcheck in the workplace.