Michael J. Hogan
@MikeHoganPhD
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Immunologist/virologist studying T cells & mRNA vaccines. Assistant Prof at Penn Vet (https://t.co/Dw70dLFnus).
Joined February 2022
Excited to share my paper, out today in @NatImmunol Nature Immunology! We discovered a HIGHLY unusual influenza peptide (named M-SL9) from a novel viral product, presented on the enigmatic MHC-E, driving a major killer T cell response in mice; 1/thread.
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STOP in the name of antigen presentation! Get your own science sticker swag by visiting @Penn_EHRS’s booths for biosafety month.
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The current mpox epidemic in central Africa is lethal, spreading, and mutating. The DRC and other affected countries must get all the vaccine doses they need ASAP if we don't want this deadly virus to spread out of control.
nytimes.com
Drugmakers have supplies ready to ship that are necessary to stop a potential pandemic. But W.H.O. regulations have slowed access.
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Interested in doing a high-impact postdoctoral fellowship at UPenn? The Hogan Lab ( is recruiting a postdoc to study mRNA vaccines for HIV and non-classical T cells restricted to MHC-E. Email CV+cover letter to mihogan@upenn.edu. Please share!
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me as a grad student: “Where can I get free food next?”. me as a PI: “Omg what am I going to do with all this free food? Also how is a tray of sandwiches so hard to carry across campus??”
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Back from a trip to Australia (conference + vacation) and found this lovely welcome message from my lab! p.s. Conrad is my cat who has many fans
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“There’s no sound I don’t like,” Aissam said, with the help of interpreters during an interview last week. “They’re all good.”. Shout out to my previous employer CHOP for their innovations in gene therapy!.
nytimes.com
The genetic treatment targeted a particular kind of congenital deafness and will soon be tried in children who are younger.
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RT @SarahMackAttack: Do you like Squid Facts?.🔲Yes.🔲No. @invertebabe designed valentines to infuse some science into your celebrations!. Th….
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Treasures found while raiding the emptied-out lab next door to mine:.-a dozen bags of 50 mL conical tubes: $125.-large box of -80 freezer boxes: $300.-case of speciality 384-well pipette tips: $626.-THIS CLOCK?! to go in my trainees' office . priceless
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RT @LabWaggoner: Intranasal mask (positively charged hydrogel) for protecting the respiratory tract against viral aerosols. 3D print an ana….
nature.com
Nature Communications - The spread of many infectious diseases substantially relies on aerosol transmission to the respiratory tract. Here, the authors design an intranasal mask with the ability to...
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RT @KingOfPathogens: Who likes enteric pathogens and the DC and CD4 T cells that control them? @iancohn and @striepenlab find a role for D….
biorxiv.org
Cryptosporidium is an enteric pathogen that is a prominent cause of diarrheal disease. Control of this infection requires CD4+ T cells, though the processes that lead to T cell-mediated resistance...
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@devarajan_priya I presented this in the Eisenlohr lab journal club last week and there was lots of interest!.
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Cytotoxic CD4 T cells are a little understood topic that holds major promise for immune therapies and vaccines. Here, my collaborator Priya Devarajan in the Swain lab reports great progress in understanding exactly how these cells are generated in the lungs during flu infection!.
So excited to share our new paper on how cytotoxic CD4 T cells develop in infected tissues after viral infection. @CellReports A tweetorial:.
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RT @bxv_imm: Interleukin-10-producing monocytes contribute to sex differences in pain resolution in mice and humans. .
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*Please share!* The Hogan Lab ( at Penn is hiring our first lab tech to start ~1/2/24. Topics include mRNA vaccines, viral immunology, and T cell protection. Job ad & instructions here:
hoganlab.org
The Hogan Lab at Penn Vet studies the determinants of protective immune responses and applies these lessons to mRNA vaccines.
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Link to episode: Time stamps for our paper: 2m30s to 12m.
open.spotify.com
The Immunology Podcast · Episode
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Check out this week's episode of "The Immunology Podcast" for a great run-down of our new [accidentally] Halloween-themed manuscript on antigens. 𝒇𝒓𝒐𝒎 𝒕𝒉𝒆 𝒄𝒓𝒚𝒑𝒕. 🧛♂️ 🎃👻.
On this week's episode: Drs. Mike Hogan, Ike Eisenlohr, and a team at @ChildrensPhila identified a nonclassical MHC epitope that directs the #Tcell response against #influenza. 📝 @NatImmunol paper: 💬 Discussion:
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RT @MauroCorradoBio: The total mass, number, and distribution of immune cells in the human body: ~2 trillion cells collectively weighting ~….
pnas.org
The immune system is a complex network of cells with critical functions in health and disease. However, a comprehensive census of the cells compris...
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RT @LabWaggoner: Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient prim….
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