Juan Melero-Martin
@MeleroMartinLab
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Associate Professor | Bioengineering, Vascular Biology, Regenerative Medicine | @BostonChildrens, @harvardmed Also at @meleromartinlab.bsky.social
Boston, MA
Joined September 2016
Our latest @Nature paper is out! We show that transplanting mitochondria into endothelial cells boosts their ability to form blood vessels in ischemic tissues, with mitophagy as the key mechanism. A potential game-changer for vascular cell therapies.
nature.com
Nature - Under stressful conditions, mesenchymal stromal cells transfer mitochondria to endothelial cells through tunnelling nanotubes, and artificially transplanting mitochondria into endothelial...
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RT @stemcellpodcast: New from the @MeleroMartinLab & Dr. @KaiWang_PKU's lab!. Dr. Liyan Gong & her colleagues generated functional vascular….
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Welcome Ziyan Liu to the lab! She’s a rising sophomore at @JohnsHopkins and joins us this summer through the @harvardstemcell HIP program to work on allogeneic stem cell therapies for vascular disease. Good luck with the experiments! #HSCI #VascularBiology #StemCells
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RT @RuiBenedito_: The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists….
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Our new Advanced Science paper is out! We show that human bone-derived endothelial cells drive bone regeneration via KIT ligand expression, revealing a vascular niche role in skeletal repair. #BoneRegeneration #KITLG #EndothelialCells #RegenerativeMedicine.
advanced.onlinelibrary.wiley.com
Bone-specific endothelial cells (b-ECs) uniquely express KITLG, which recruits c-Kit+/CD34+ hematopoietic progenitors (HPCs) to the osteovascular niche, initiating a cascade that culminates in the...
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RT @newscientist: Blood vessels grown in the lab in just five days could quickly prevent the tissue damage that can occur after an accident….
newscientist.com
Blood vessels grown in the lab in just five days could quickly prevent the tissue damage that can occur after an accident
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RT @GENbio: Rapid Formation of Vascular Organoids from #iPSCs via TF Activation. A dual #transcriptionfactor activation method enables rapi….
genengnews.com
A dual transcription factor activation method enables rapid generation of vascular organoids, accelerating modeling and therapy development.
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RT @CellStemCell: Online Now! Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothe….
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And a big thank you to @BostonChildrens, @harvardmed, and the @NIH, @NIH_NHLBI, and the @BreakthroughT1D for funding this study!.
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A big shoutout to Liyan Gong (first author), Kai Wang and the rest of the co-authors: Yadong Zhang, Yonglin Zhu, Umji Lee, Allen Chilun Luo, Xiang Li, Xi Wang, Danyang Chen, William T. Pu, Ruei-Zeng Lin, Minglin Ma, Miao Cui, and Kaifu Chen.
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Our latest @CellStemCell paper is out! We show how orthogonal activation of #ETV2 and #NKX3.1 in #iPSCs generates vascular organoids with functional microvasculature. A powerful platform for vascular therapies.
cell.com
Melero-Martin and colleagues developed a rapid method to generate vascular organoids from human iPSCs by orthogonally activating the transcription factors ETV2 and NKX3.1. This strategy enabled...
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New in @NatureCVR! ETV2 guides endothelial cell fate by recruiting REST to repress alternative lineages. This paper offers new insights into EC specification using single-cell multi-omics. Glad to have contributed!.#ETV2 #endothelialcells #stemcells.
nature.com
Nature Cardiovascular Research - Chen et al. employ multiple approaches to show that ETV2 recruits the transcriptional repressor REST, facilitating mesoderm-to-endothelial cell specification, while...
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Excited to share our new review, now online at Trends in Cell Biology! We discuss mitochondrial transfer in endothelial cells and its role in vascular health. @BostonChildrens @harvardmed @CellPressNews .
cell.com
Mitochondria play a vital role in cellular energy metabolism and vascular health, with their function directly influencing endothelial cell (EC) bioenergetics and integrity. Mitochondrial transfer...
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RT @Madam_Mito: Mitochondrial transfer in endothelial cells and vascular health: Trends in Cell Biology
cell.com
Mitochondria play a vital role in cellular energy metabolism and vascular health, with their function directly influencing endothelial cell (EC) bioenergetics and integrity. Mitochondrial transfer...
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Exciting new work from @BischoffJoyce just out in @JClinInvest! They reveal how the endothelial SOX18–mevalonate pathway axis opens the door to repurposing statins for treating infantile hemangioma. Editor’s Note:
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Excited to be a speaker at the @MbD_UofT Global Speaker Series on January 21! Looking forward to sharing insights from our work at @BostonChildrens and @harvardmed. Hope to see you there!.
Join us for our next Global Speaker Series talk on January 21 featuring Juan Melero-Martin from Boston Children's Hospital, Harvard Medical School. Save your spot today: This Global Speaker Series is in partnership with the @McEwenInstitute
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RT @PacBio: NEW: GutID, the first commercial human gut health test powered by HiFi sequencing, sets a new benchmark in gut microbiome testi….
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Yesterday, we celebrated the holidays at our annual Department of Cardiac Surgery party! The Melero-Martin Lab enjoyed great food, a few drinks, and even better company. Grateful for such an amazing team. Wishing you all a joyful holiday season! 🎊🎄✨@BostonChildrens @harvardmed
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RT @CellStemCell: Online Now! Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug….
cell.com
Pan et al. generate lineage-specific venous endothelial cells with a heterozygous TIE2-mutation from human iPSCs to recapitulate venous malformations in vitro and in vivo. Deep learning combined with...
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Our lab just got bigger! This fall, we welcomed three new postdocs—Dr. Shih-Yen Wei (Taiwan), Dr. JinJu Kim (Korea), and Dr. Youlu Chen (China)—and visiting student Hyunjung Kim (Korea) to our team at @BostonChildrens and @harvardmed. Welcome aboard!.
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