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Juan Melero-Martin Profile
Juan Melero-Martin

@MeleroMartinLab

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Associate Professor | Bioengineering, Vascular Biology, Regenerative Medicine | @BostonChildrens, @harvardmed Also at @meleromartinlab.bsky.social

Boston, MA
Joined September 2016
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@MeleroMartinLab
Juan Melero-Martin
1 year
Our latest @Nature paper is out! We show that transplanting mitochondria into endothelial cells boosts their ability to form blood vessels in ischemic tissues, with mitophagy as the key mechanism. A potential game-changer for vascular cell therapies.
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nature.com
Nature - Under stressful conditions, mesenchymal stromal cells transfer mitochondria to endothelial cells through tunnelling nanotubes, and artificially transplanting mitochondria into endothelial...
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@MeleroMartinLab
Juan Melero-Martin
8 days
RT @stemcellpodcast: New from the @MeleroMartinLab & Dr. @KaiWang_PKU's lab!. Dr. Liyan Gong & her colleagues generated functional vascular….
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@MeleroMartinLab
Juan Melero-Martin
27 days
Welcome Ziyan Liu to the lab! She’s a rising sophomore at @JohnsHopkins and joins us this summer through the @harvardstemcell HIP program to work on allogeneic stem cell therapies for vascular disease. Good luck with the experiments! #HSCI #VascularBiology #StemCells
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@MeleroMartinLab
Juan Melero-Martin
28 days
RT @RuiBenedito_: The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists….
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@MeleroMartinLab
Juan Melero-Martin
1 month
Our new Advanced Science paper is out! We show that human bone-derived endothelial cells drive bone regeneration via KIT ligand expression, revealing a vascular niche role in skeletal repair. #BoneRegeneration #KITLG #EndothelialCells #RegenerativeMedicine.
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advanced.onlinelibrary.wiley.com
Bone-specific endothelial cells (b-ECs) uniquely express KITLG, which recruits c-Kit+/CD34+ hematopoietic progenitors (HPCs) to the osteovascular niche, initiating a cascade that culminates in the...
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@MeleroMartinLab
Juan Melero-Martin
1 month
RT @newscientist: Blood vessels grown in the lab in just five days could quickly prevent the tissue damage that can occur after an accident….
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newscientist.com
Blood vessels grown in the lab in just five days could quickly prevent the tissue damage that can occur after an accident
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@MeleroMartinLab
Juan Melero-Martin
1 month
RT @GENbio: Rapid Formation of Vascular Organoids from #iPSCs via TF Activation. A dual #transcriptionfactor activation method enables rapi….
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genengnews.com
A dual transcription factor activation method enables rapid generation of vascular organoids, accelerating modeling and therapy development.
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@MeleroMartinLab
Juan Melero-Martin
1 month
RT @CellStemCell: Online Now! Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothe….
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cell.com
Melero-Martin and colleagues developed a rapid method to generate vascular organoids from human iPSCs by orthogonally activating the transcription factors ETV2 and NKX3.1. This strategy enabled...
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@MeleroMartinLab
Juan Melero-Martin
1 month
And a big thank you to @BostonChildrens, @harvardmed, and the @NIH, @NIH_NHLBI, and the @BreakthroughT1D for funding this study!.
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@MeleroMartinLab
Juan Melero-Martin
1 month
A big shoutout to Liyan Gong (first author), Kai Wang and the rest of the co-authors: Yadong Zhang, Yonglin Zhu, Umji Lee, Allen Chilun Luo, Xiang Li, Xi Wang, Danyang Chen, William T. Pu, Ruei-Zeng Lin, Minglin Ma, Miao Cui, and Kaifu Chen.
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@MeleroMartinLab
Juan Melero-Martin
1 month
Our latest @CellStemCell paper is out! We show how orthogonal activation of #ETV2 and #NKX3.1 in #iPSCs generates vascular organoids with functional microvasculature. A powerful platform for vascular therapies.
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cell.com
Melero-Martin and colleagues developed a rapid method to generate vascular organoids from human iPSCs by orthogonally activating the transcription factors ETV2 and NKX3.1. This strategy enabled...
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@MeleroMartinLab
Juan Melero-Martin
1 month
New in @NatureCVR! ETV2 guides endothelial cell fate by recruiting REST to repress alternative lineages. This paper offers new insights into EC specification using single-cell multi-omics. Glad to have contributed!.#ETV2 #endothelialcells #stemcells.
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nature.com
Nature Cardiovascular Research - Chen et al. employ multiple approaches to show that ETV2 recruits the transcriptional repressor REST, facilitating mesoderm-to-endothelial cell specification, while...
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@MeleroMartinLab
Juan Melero-Martin
2 months
Excited to share our new review, now online at Trends in Cell Biology! We discuss mitochondrial transfer in endothelial cells and its role in vascular health. @BostonChildrens @harvardmed @CellPressNews .
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cell.com
Mitochondria play a vital role in cellular energy metabolism and vascular health, with their function directly influencing endothelial cell (EC) bioenergetics and integrity. Mitochondrial transfer...
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@MeleroMartinLab
Juan Melero-Martin
2 months
RT @TrendsCellBio: Mitochondrial transfer in endothelial cells and vascular health
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@MeleroMartinLab
Juan Melero-Martin
4 months
Exciting new work from @BischoffJoyce just out in @JClinInvest! They reveal how the endothelial SOX18–mevalonate pathway axis opens the door to repurposing statins for treating infantile hemangioma. Editor’s Note:
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@MeleroMartinLab
Juan Melero-Martin
6 months
Excited to be a speaker at the @MbD_UofT Global Speaker Series on January 21! Looking forward to sharing insights from our work at @BostonChildrens and @harvardmed. Hope to see you there!.
@MbD_UofT
Medicine by Design
7 months
Join us for our next Global Speaker Series talk on January 21 featuring Juan Melero-Martin from Boston Children's Hospital, Harvard Medical School. Save your spot today: This Global Speaker Series is in partnership with the @McEwenInstitute
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@MeleroMartinLab
Juan Melero-Martin
6 months
RT @PacBio: NEW: GutID, the first commercial human gut health test powered by HiFi sequencing, sets a new benchmark in gut microbiome testi….
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@MeleroMartinLab
Juan Melero-Martin
7 months
Yesterday, we celebrated the holidays at our annual Department of Cardiac Surgery party! The Melero-Martin Lab enjoyed great food, a few drinks, and even better company. Grateful for such an amazing team. Wishing you all a joyful holiday season! 🎊🎄✨@BostonChildrens @harvardmed
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@MeleroMartinLab
Juan Melero-Martin
8 months
RT @CellStemCell: Online Now! Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug….
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cell.com
Pan et al. generate lineage-specific venous endothelial cells with a heterozygous TIE2-mutation from human iPSCs to recapitulate venous malformations in vitro and in vivo. Deep learning combined with...
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@MeleroMartinLab
Juan Melero-Martin
8 months
Our lab just got bigger! This fall, we welcomed three new postdocs—Dr. Shih-Yen Wei (Taiwan), Dr. JinJu Kim (Korea), and Dr. Youlu Chen (China)—and visiting student Hyunjung Kim (Korea) to our team at @BostonChildrens and @harvardmed. Welcome aboard!.
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