Mehandru Lab @MountSinai
@MehandruLab
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We study the human mucosal immune system with a focus on IBD and HIV to determine mechanisms of disease pathogenesis and predictors of therapeutic response
New York
Joined June 2021
Out today the last piece of work that Maria Guillamot did in our lab in a collaboration with @AWeinstock and @DrShrutiNaik (who lead the study) showing type I interferon (IFN)-mediated activation of hematopoietic stem/progenitor cells resulting in profound changes to systemic
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New result from #theonlylabever @uoftmedicine @UofT . open access link here (until Feb 2025) https://t.co/UYuh343tFH Many thanks to @Es_cheri_chia for the excellent editorial work. Hope you will find it interesting.
Now online! A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity
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📢Thrilled to share our work on the ontogeny, reactivity, and function of #IgA subclasses in homeostasis and #IBD! Huge thanks to Andrea, all our amazing collaborators, and @JExpMed for their support throughout the extended revision process! It's time to celebrate🥳!
Tejedor Vaquero, Neuman, Mehr, Cerutti, @GMagri_Immuno @HMar_research et al. show that gut IgA1 & IgA2 subclasses co-emerge early in life, largely derive from clonally related and somatically mutated plasma cells in adults, & show unique changes in #IBS. https://t.co/B7u4GIs7Vg
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Tejedor Vaquero, Neuman, Mehr, Cerutti, @GMagri_Immuno @HMar_research et al. show that gut IgA1 & IgA2 subclasses co-emerge early in life, largely derive from clonally related and somatically mutated plasma cells in adults, & show unique changes in #IBS. https://t.co/B7u4GIs7Vg
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#Eosinophils mitigate intestinal #fibrosis while promoting inflammation in a chronic DSS colitis model and co-culture model with fibroblasts by @jacobsinge8 @DeleuSara @gmatteoli1978 @SeverineVermei1 @VanuytselTim @bverstockt @TARGID_KULEUVEN
https://t.co/ShxZyY3hH6
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Anti-integrin αvβ6 autoantibodies are increased in PSC patients with concomitant IBD and correlate with liver disea…
pubmed.ncbi.nlm.nih.gov
Anti-αvβ6 autoantibodies identify a subset of patients with PSC with concomitant IBD.
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A fantastic day celebrating the 40th anniversary of the discovery of the TCR. Check out this T cell speaker photo which includes co-discoverers Tak Mak and Mark Davis. Thanks @UofT, @uoftmedicine, @ImmunologyUofT, @thePMCF for your support.
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Please RT 🙏!📢My lab at @UniBarcelona is seeking a highly motivated postdoc to lead an exciting new public-private collaborative project (UB, CRG, CSIC, OrikineBio) aimed at testing a potentially game-changing therapy for IBD. If interested, please contact me at gmagri@ub.edu.
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Very honored to receive the International @Inserm Prize today at the French Embassy in DC. Great evening with @Inserm CEO Didier Samuel, Ambassador Lilli, and wonderful colleagues, celebrating France/US partnerships and our shared commitment to advancing science across borders.
Bravo à @MiriamMerad chercheuse à l’Ecole de médecine du @MountSinaiNYC qui reçoit le #prixinternational 2024 de l’Inserm ! Il salue son travail exceptionnel en immunologie du #cancer et des maladies inflammatoires, symbole de la collaboration scientifique franco-américaine.
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New research from @MehandruLab describes the depletion of germinal center B cells and IgA+ plasma cells in the #GI tracts of people living with #HIV. @francescacossa1 Read more in Science #Immunology: https://t.co/AddkkyWKbD
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Celebrating our PI @NinaBhardwaj! What an amazing week; elected to the National Academy of Medicine on Monday, then selected as Inventor of the Year (Mount Sinai Innovation Awards)…we are all so proud to be in your lab! Cheers 🥂!
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Out now 🚨 in @AGA_Gastro is your latest update on selective IL-23p19 inhibition in IBD! Amongst other topics featuring discussion of pathogenesis, PD/PK, efficacy, safety, positioning, and more! Together with @JeanFredericCo1 @MehandruLab & @ryanungaro
https://t.co/E6ac1n4Zf8
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Every year, @JeanFredericCo1 hosts the GI Division #IBD Retreat to address challenging topics in #IBD. We're proud to keep the tradition going this year at IBD Retreat 2024! Register here to join: https://t.co/W9RDBvqc6U
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Great work from @MehandruLab & congrats on this #PosterOfDistinction at #DDW2024! @divyajha_phd walks us through the intricate role of cellular dynamics within the epithelial compartment and their impact on treatment responses of therapies used in #ulcerativecolitis management.
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🙏🏼🙏🏼🙏🏼pumped for the naik lab move to @SinaiImmunol and to be part of this vibrant and exciting community of immunologists and for the breakthrough discoveries we will make together @MiriamMerad @brianbrown #naiklabmoveuptown
🍾CONGRATULATIONS🍾 to the fantastic @DrShrutiNaik on winning this year's @LeoFondet award in recognition of her visionary skin research program encompassing dermatology, neuroimmunology and more! Read all about it >>>
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🍾CONGRATULATIONS🍾 to the fantastic @DrShrutiNaik on winning this year's @LeoFondet award in recognition of her visionary skin research program encompassing dermatology, neuroimmunology and more! Read all about it >>>
leo-foundation.org
This year’s winner of the LEO Foundation Award in Region Americas, Dr. Shruti Naik, is recognized for her transformative contributions to skin science. Dr. Naik has been awarded USD 100,000 to...
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How does vedolizumab work in ulcerative colitis patients? Researchers in a new @SciImmunology study say the drug targets gut-associated lymphoid tissue. Learn more: https://t.co/VMU2yK8qTa
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Explore Dr. Saurabh Mehandru's latest research uncovering vedolizumab's impact on gut-associated lymphoid tissue (#GALT) in #IBD treatment. Gain fresh insights into therapeutic response mechanisms: https://t.co/u0BQitPmTT
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How does vedolizumab work in ulcerative colitis patients? Researchers in a new @SciImmunology study say the drug targets gut-associated lymphoid tissue. Learn more: https://t.co/88dIHOwfxe
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