Del Valle Lab
@DelValleLab
Followers
559
Following
130
Media
51
Statuses
93
Organic synthesis and chemical biology lab at Notre Dame... Putting the 'PEP' in peptides.
Notre Dame, IN
Joined June 2019
Ever wondered how intra-strand staples impact beta-sheet stability? Check out our @J_A_C_S paper on an easy method to promote peptide folding and amyloid seeding activity. Congrats to Abha and Isaac!!
pubs.acs.org
Side chain stapling of cysteine (Cys) residues offers convenient entry into constrained peptides with enhanced bioactivity and bioavailability. Despite its widespread application in the constraint of...
3
13
84
Some recent publication news from the lab. First, congrats to @mmwright417 for her paper exploring the impact of azapeptoid residues on collagen stability, now out in Peptide Science!
onlinelibrary.wiley.com
Collagen, the major structural protein in connective tissue, adopts a right-handed triple helix composed of peptide chains featuring repeating Gly-Xaa-Yaa tripeptide motifs. While the cyclic residu...
0
2
20
Hot off the press in @NatureChemistry: Our paper on seed-competent stapled peptides that mimic the core fold of pathological tau! Huge congrats to Isaac, Ben, and collaborators in the Jiang and Vidal labs. #PeptideScience #tau
nature.com
Nature Chemistry - Molecules that recapitulate the structure and prion-like activity of misfolded tau hold promise as more relevant models of pathological tau propagation. Now, the macrocyclization...
2
12
71
Check out this Just Accepted paper from @Avraz__Anwar describing a streamlined synthesis of N-amino peptides. This general protocol will vastly accelerate studies on amide-to-hydrazide replacement in peptides. Congrats, Avraz!
pubs.acs.org
We report an optimized protocol for the solid-phase synthesis of backbone-N-aminated peptides. Electrophilic N-amination of amino acid zwitterions provides crude α-hydrazino acids that can be used...
0
3
37
RSC Chemical Biology paper in collaboration with the Stahelin just accepted! Stapled peptides targeting the dimer interface of the Ebola virus VP40 matrix protein. Congrats to Madi, Roopashi, and collaborators in the Stahelin and Chapagain labs!
pubs.rsc.org
The Ebola virus (EBOV) is a filamentous lipid-enveloped RNA virus that can cause viral hemmorhagic fever and has a high fatility rate. EBOV encodes seven genes including the lipid-binding matrix...
1
1
18
The fun with unnatural proline surroagtes continues. Check out our paper on stabilized aPP proteomimetics. Congrats to first author @mmwright417 and special thanks to collaborators in the Horne and Smith labs!
nature.com
Communications Chemistry - Proline plays an important role in mediating protein folding and stability, however, the impact of noncanonical proline analogues on protein folding and stability is not...
0
5
28
Our paper on delta-heteroatom proline surrogates in collagen is now online. Congrats to Taylor, Madi, and Natalia!
pubs.rsc.org
We describe the first investigation of collagen mimetic peptides harboring proline surrogates with heteroatoms at the δ-position. While dehydro-δ-azaproline and (N-methyl)-δ-azaproline destabilized...
0
2
15
Congrats to @Avraz__Anwar, whose total synthesis of marformycins A&D appeared in in @JOC_OL! Special thanks to Yassin and collaborators in the @R_H_Ebright lab.
pubs.acs.org
We report the synthesis of the antimicrobial cyclodepsipeptides marformycin A (1) and marformycin D (2) using a solid-phase approach. A scalable solution-phase synthesis of the γ-hydroxypiperazic...
1
3
24
Last week the lab got together to bid farewell to @b_raj12 aka Dr. "beta-bracelet". Congrats, Ben, and all the best in Chicago!
0
1
19
New Acc. Chem. Res. from the lab dropped online yesterday: Right on first author Isaac's birthday, and one day before second author Madi's birthday. Practically twinsies! Happy bday guys! 🎂
2
1
45
Huge week for 5th year @b_raj12. Thesis defense, Dow outstanding grad student award, and birthday to boot! Congrats Ben! 🥂
0
3
26
At last. we're thrilled to send our story on macrocyclic mini-tau seeds out into the world. Organic chem, protein mimicry, cryo-EM, cell function; something for everyone! Congrats to Isaac & Xueyong, and collabs from Purdue and IUSM!.
0
6
39
Congrats to Isaac Angera for taking home a 2nd place poster award at the 2024 Peptides GRC!! Well-deserved! Stay tuned for more on his exciting foray into "mini-tau" macrocycles.
0
2
45
RT @ChemMedChem: #OnTheCover Stabilizing Pseudouridimycin: Synthesis, RNA Polymerase Inhibitory Activity, and Antibacterial Activity of Dip….
0
1
0
4 new group members this month! Thrilled to welcome postdoc Abha Dangi, and 1st year grad students Ana-Teresa Mendoza, Alexandre Renon, and Fadwa Kamari. Welcome to the team!
0
1
25
RT @Avraz__Anwar: Had an amazing time at the Purdue University Notre Dame Symposium (PUNDS). There were so many great talks/research being….
0
1
0
Hats off to Theo and Natalia, who passed their candidacy exams this month!👏🎉 Cake, coats, and congrats on job well done!!
1
0
15
RT @AusPeptide: Almost the end of #AusPeptide2023 sadly! Thank you all for coming and having a great time, giving amazing presentations and….
0
22
0
Excited to share our story on cross-beta epitope mimics targeting tau propagation, out now in @J_A_C_S. Grateful to all involved on this project, and a special congrats to first author @b_raj12!!
pubs.acs.org
The aggregation of misfolded tau into neurotoxic fibrils is linked to the progression of Alzheimer’s disease (AD) and related tauopathies. Disease-associated conformations of filamentous tau are...
0
9
50
Check our latest pub describing stabilized PUM analogues. Congrats to @Avraz__Anwar, Chris, and Michael Garza; and our collaborators in the @R_H_Ebright lab!
chemistry-europe.onlinelibrary.wiley.com
Strategic modification of the guanidine tail and central hydroxamate bond in the antibacterial natural product pseudouridimycin (PUM) dramatically enhances its chemical stability. Three hydroxamate...
0
2
15