Matthew Ryan King
@MattKingLab
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I study floppy proteins and teach students who are incarcerated | https://t.co/IEka0gToDJ
St Louis, MO
Joined June 2019
Floppy protein phase separates to make microtubules grow off each other super efficiently. (Shameless self promotion 🙃)
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Congratulations to @DanaFarber's Cigall Kadoch, PhD, (@CKadoch) who was named as the Laureate of the Blavatnik National Awards for Young Scientists today. The prestigious award from @BlavatnikAwards and @NYASciences (cont) https://t.co/eGr7a5hkkQ
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Congratulations to Avnika Pant on receiving a scholarship & invitation to attend the @MBLScience Physiology program this summer! This selective and intensive program is one of the oldest continually running biology courses. Avnika is a doctoral student with @PappulabWashU.
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🔥🔥How does the LINE-1 retrotransposon jump around in the human genome? Super excited to present my postdoctoral work answering this published today @Nature together with twitterless Kathy Collins's lab and @NogalesLab @UCBerkeley
https://t.co/quoQOpZb5X A 🧵
nature.com
Nature - Human LINE-1 ORF2p relies on upstream single-stranded target DNA to position the adjacent duplex in the endonuclease active site for nicking of the longer DNA strand, with a single nick...
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Congrats to @sophiembtravis and team from @RuiZhangWUSTL and @LabPetry on the augmin structure! Also congrats to @PfefferCryoLab and @lchangpurduebio for their structural work!
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Have you wondered how a decades-old oocyte can give rise to a new embryo while other cells in the body age? Our study @Nature, spearheaded by @AidaRoNu, uncovers the mechanism that allows early #oocytes to maintain ROS-free #mitochondria
https://t.co/eVQfeRWmVq🧵
nature.com
Nature - Oocytes prevent the production of reactive oxygen species by remodelling the mitochondrial electron transport chain through elimination of complex I, a strategy that enables their...
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Happy to present a new preprint from @MarileenD’s lab, in which we ask if a microtubule plus-end tracking comet is held together by interactions that also drive phase separation. The answer is not a clear ‘yes’ or ‘no’, so here goes the 🧵1/10
Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus ends
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You Were Duped Into Saying Yes. Is That Still Consent?
nytimes.com
Legal scholars have long debated this question. Recent psychological studies shed new light.
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At some point you have to admit that doing things ironically can have very straightforward consequences. #FakeAccountsClub @laurenoyler
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Why am I "the only person who can see the true essence of this book?" Any thoughts @laurenoyler?
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Beautiful work officially out by @SagarSetru, Bernardo deGouveia, Josh @shaevitz and Howard Stone - a tri-departmental @Princeton collaboration. What do drops on spiderwebs and protein droplets on microtubules have in common? #PhaseSeparation on Cellular Surfaces
A hydrodynamic instability drives protein droplet formation on microtubules to nucleate branches
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My kitties - Jenny and Emmy - couldn’t be prouder of their namesakes’ - Jennifer @doudna_lab and Emmanuelle #NobelPrize #CRISPR
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Frogs rule!
Xenobots are programmable organisms made from the cells of frog embryos -- golems dreamed in silicon and then written into flesh. Should bioethicists be concerned?
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Once again: DO NOT TRACK THE NUMBER OF CASES. THIS IS SUPPOSED TO INCREASE AS TESTING COMES ONLINE. Instead, track the number of deaths per day. If the "doubling time" of these slows to more than 3 days, we're starting to bend the curve. thread:
Bookmark this. When the doubling time of deaths* gets above 3 days, we will have begun to get past the runaway period of the pandemic. Note the current doubling times for China (35 days) & South Korea (12 days). *not cases, which can be underdiagnosed
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As promised, here is our first glimpse of the #COVID19 spike protein (aka the demogorgon) in action, courtesy of @foldingathome . More to come!
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So thrilled and honored to receive the Harold Weintraub Award for my graduate research! @WeintraubAward @fredhutch
https://t.co/w2gXACo276
fredhutch.org
Fred Hutch Announces 2020 Harold M Weintraub Award Winners
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Non-spherical coacervates are cool! I was wondering when this would be coming out. Congrats @luiree and Kasper!
PNPase mediated UDP Polymerization leads to non-isotropic Poly(U) * Spermine Coacervate Growth. High phosphate levels drive Poly(U) Depolymerization & Coacervate Dissolution. By @luiree & @MarileenD. Now in Langmuir: https://t.co/JipA6v24Uk
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In a paper just published Rohit Pappu’s and my lab show that the number of stickers and their patterning determine LLPS of prion-like LCDs. Our findings lead to a numerical model that enables the prediction of full binodals from the sequence. https://t.co/WwZ8m3TT2T (1/15)
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Come explore the Physics of Life. A summer school for advanced undergraduates. We have space for 24 students, with all local expenses covered and no tuition or fees.
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