Martin Lauritzen Lab
@transneuro_lab
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Research in this laboratory @uni_copenhagen is focused on the neural and astrocytic mechanisms of local vascular regulation.
Capital Region, Denmark
Joined January 2018
Our new article in Nature Aging is now published online. We reported an age-related decrease in responsivity of brain micro vessels, accompanied by a decrease in vessel density and loss of vascular mural cell processes. @lundbeckfonden
@neuroscience_dk
https://t.co/AN75nPia6s
nature.com
Nature Aging - Frailty of the aged brain may relate to impaired vascular control and limitations in energy supply. The authors report an age-related decrease in responsivity of brain microvessels,...
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Online now! In vivo 4D #2-photon imaging study reports an age-related decrease in mouse brain microvessels responsivity, decrease in vessel density & loss of vascular mural cell process @MartinMlauritz @ChangsiCai @transneuro_lab
https://t.co/KmKvrpzMQC
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Conclusion: In the #Brain 🧠, #Microvasculature is not #Innervated like in #PeripheralTissue. #PrecapillarySphincters and/or #FirstOrderCapillaries are central to #NeurovascularCoupling, which may be enhanced by a perpendicular arrangement of #NeuronalProcesses (12/15)
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🐭#Brain #Microvasculature is not #Innervated. But #Parenchymal #NeuronalProcesses arrange perpendicular to #Arteriole direction where #PerivascularSpace exists, while #AscendingVenules do not have this arrangement (10/15)
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#Astrocytes are normally depicted as #Parenchymal somas with processes reaching the #bloodvessels. Here, I show that #AstrocyteSoma are part of the #Endfeet around #PenetratingArterioles and #AscendingVenules (9/15)
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At the #PrecapillarySphincter and #NeurovascularUnit, I show: #EndothelialCell, #MuralCell, #Fibroblast, #Macrophage, #Astrocyte and #Neuron. Also, structures: #ContractileElement, #MyoendothelialJunction, #PinocyticVesicle, #Collagen, #Elastin, #Glycocalyx (6/15)
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Results: In this study of the #MICrONS 🐭👁️-cortex 3D #ElectronMicroscopy dataset, I show how the shape of #Contractile #MuralCells transition from #PenetratingArteriole to #PrecapillarySphincter to #Capillaries. Vascular lumen = blue, mural cells = various colors (5/15)
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The function 🧑🔧 of the #PrecapillarySphincter is to control the #BloodFlow to the #Capillaries, securing adequate distribution of blood flow between the upper and lower cortical layers. For more, check these🧵: https://t.co/HWkL6XoKAh and https://t.co/Zkb3AyXKRX (4/15)
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‼️Importantly, #PrecapillarySphincters exist where a #Capillary branches from a much larger #Arteriole (≈upper cortical layers) but not when there is a more gradual transition (≈lower cortical layers). (3/15)
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🔥🔥🔥Exciting news! Today @biorxiv_neursci, #preprint on the #Ultrastructure of #PrecapillarySphincters and the #NeurovascularUnit. This study is based on the https://t.co/SRzAuzTZSD dataset by @AllenInstitute. Check 🧵 for more details, including movies of the findings. (1/15)
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How to use #twophoton #microscopy to investigate #bloodbrainbarrier transport and #CNS #drugdelivery? Check the summary of our work @transneuro_lab, where we pit #fluorescence #imaging #invivo against classical approaches to study the #brain and #BBB
https://t.co/zvwCFpSaXE
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It is our sincere pleasure to receive funding from @DCAcademyDK for #imaging #nano-scale motion of blood #vessels with two-photon #microscopy.
Very happy to receive a PostDoc fellowship from @DCAcademyDK for studying nano-scale motion of blood vessels @UCPH_health @neuroscience_dk. Fantastic Christmas gift!
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This collaborative effort between @uni_copenhagen @UCPH_health @aausund and @DTU_HealthTech was supported by @lundbeckfonden @nordeafonden and @DFF_raad Congrats to all involved @transneuro_lab @KasperBJohnsen @TorbenMoos2 @micael_micl @MartinMlauritz Stay tuned for more videos!
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I am honored for the invitation to present our work on ApoM/S1P regulation of the #BBB #paracellular permeability and #transcytosis at the #FASEB #LRMSRC21 today at 2:05PM(ET). https://t.co/tTmWgEMSl7
@MartinMlauritz @transneuro_lab @kucharz_neuro @lundbeckfonden @nordeafonden
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Our #twophoton #bbb paper has just got nice press coverage. Thank you @uni_copenhagen @UCPH_health for this great outreach article! @aausund @DTU_HealthTech @transneuro_lab @KasperBJohnsen @TorbenMoos2 @micael_micl @MartinMlauritz
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Please read this thread!
I am very proud to contribute to a @CompBiochPhys @elsbiomedchem collection of review papers celebrating the Legacy of August Krogh, 1920-2020. https://t.co/YHCIU323XJ. I have made a thread below describing our contribution, and how it relates to the work of #AugustKrogh. 1/16
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Deadline extended ‼️ You can still register to the #BrainConference "Brain Stroke: Why, how and hope"! Join a panel of international speakers to discuss the latest advances in #research on #BrainStroke! Register now: https://t.co/n2nUrQoNm3
#Stipends available
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This new discovery by @sorengrubb and @transneuro_lab changes the understanding of the blood circulation in the #brain. Read more: https://t.co/aVfmFq1bOm
@neuroscience_dk, @lundbeckfonden #neuroscience
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New paper in @NatureComms from our lab @uni_copenhagen @UCPH_health about #precapillarysphincters in the #brain. A big thanks to @lundbeckfonden and @DFF_raad for supporting this study! #neuroscience #dkforsk
Today our #neuroscience #research #paper about #PrecapillarySphincters in the #Brain is live on @NatureComms: https://t.co/dIQb5Cr3BG. I’m so proud of our work @Uni_Copenhagen @UCPH_Health @Neuroscience_dk and would like to share it with you in the following tweets. #happy (1/10)
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