Mark Blaser, PhD
@MarkCBlaser
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Research Scientist @CICSnews/@bwhcvls/@Harvardmed: #multiomics+#EVs+#drugdiscovery+#cardiovascularbiology | via @bme_uoft & @ChemEngMcGill | FHG1969
Boston, MA
Joined May 2011
Using mass spectrometry-based plasma & tissue proteomics, we identify specific fibrotic matrix constituents and metabolism pathways unique to #AS pathogenesis in female patients. More soon!
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There’s glaring sex disparities in the pathology & tx of aortic stenosis #AS. Here's a sneak peak at work led by @caseylclift & I, where we begin to unravel sexually-dimorphic molecular fingerprints associated with fibrocalcific disease progression:.
biorxiv.org
BACKGROUND Calcific aortic valve stenosis (CAVS) is a global clinical burden, impacting around 2% of the population over 65 years of age. No pharmacotherapeutics exist, with surgical repair and...
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RT @AppliedCVB: Member publication alert:. Calcific aortic stenosis: omics-based target discovery and therapy development. .
academic.oup.com
Abstract. Calcific aortic valve disease (CAVD) resulting in aortic stenosis (AS) is the most common form of valvular heart disease, affecting 2% of those o
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Excited to publish our State of the Art Review on #multiomics & #pharmacotherapy in #aorticstenosis #AS with @ProfMagnusBack, @ESC_President @TomLuscher, & @AikawaElena in the European Heart Journal. Thanks for the invitation @ehj_ed #EHJ @ESC_Journal!.
academic.oup.com
Abstract. Calcific aortic valve disease (CAVD) resulting in aortic stenosis (AS) is the most common form of valvular heart disease, affecting 2% of those o
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RT @CICSnews: @CNSerhanLab Our fellows @MarkCBlaser @Prabhash_PKJ and @srvsh_c shared their research and got expert feedback about pro-reso….
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RT @pnatarajanmd: Many patients with calcific aortic stenosis surprisingly do not have notable coronary artery disease. Delighted to contri….
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Pleased to share my editorial w/ @AikawaElena in @JAMACardio, where we tackle disease drivers of #aorticstenosis #AS vs #CAD in the context of an elegant new GWAS of #AS-specific risk loci by Trenkwalder et al. Article: Editorial:
jamanetwork.com
Aortic stenosis (AS) due to fibrosis and calcification of the aortic valve is a hazardous component of cardiovascular disease burden—after developing symptomatic AS, patients survive for an average...
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I just received an invitation to peer review a review article that has blatantly plagiarized something I wrote 3 years ago. Does. does this mean I've "made it"?.
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Single-sourcing & lack of resiliency is absolutely driven by a mindset of profit > everything, including pt health. That isn't gonna work anymore, unless we're willing to shoulder large+lengthy+increasingly frequent disruptions of critical supplies+services+infrastructure.
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We need to adapt to climate change by diversifying/increasing resiliency of single source/just-in-time supply chains. Helene KO'd a mine that supplies all quartz for semiconductor mfg worldwide. In '23 a tornado took out 1/4 of Pfizer's sterile injectable mfg cap. It's here. .
We have created a healthcare system in which there is never a shortage of opiates or Botox but where elective heart surgery is cancelled because of a nationwide shortage of IV fluids.
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Congrats @mandyturner_!.
Congratulation to CICS’ post doc @mandyturner_ 🎉🏆👏She received a micro grant from Brigham Research Institute to characterize circulating phosphate nanoparticles as a disease driver of calcific cardiovascular disease. @harvardmed @bwhcvls @AikawaElena @BrighamResearch @IsevOrg
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very demure, very mindful.
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RT @American_Heart: Diagnosed with aortic stenosis at 16, Claire avoided surgery valve surgery until her 30s, when at 4 months pregnant, do….
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