Did we get dietary saturated fats all wrong? The #HADLmodel provides a new understanding and an opportunity to get it right. THREAD👇👇👇.@simondankel @kariannesve

Really enjoyed our talk, @TyRBeal .Let's hope this can add to the somewhat confusing discussion on UPFs (or ultra-processed products, as we argue for). It's not about salt, sugar and (saturated) fat. It's about evolutionary mismatched foods.

". a higher contribution of unhealthy plant foods was associated with a higher prevalence of MetS . and elevated TAG". "Plant based diet", as a term for guiding food choices, is useless.

If you want to understand the science behind the headlines, this episode is worth a listen. PS: I speak a bit slowly in English — feel free to listen at 1.2x speed.

You won’t hear me listing additives to avoid. The list is incomplete, and changes continuously. At this point, it is far more useful to try to shift towards mostly whole foods, than to obsess over which ultra-processed product has the “least bad” label.

We talk about everything from what’s in the food—nutrients, structure, additives, pollutants, process-derived chemicals—to how these things actually interact with our biology. We also talk about food as information for the body.

Your genes, your environment, and the stressors you face all shape how you respond to this evolutionary foreign diet that acts like a major inflammatory trigger.

The risk isn’t down to a single culprit—it’s the combined effect of many factors that together overwhelm the systems our bodies evolved to keep us healthy.

🎧 What’s wrong with ultra-processed diets?. That’s the question I got to dig into with @TyRBeal 🙏.

"Multiple regression analysis showed that consumption of ultra-processed foods contributed to the levels of several dl-PCBs in meconium".

". reducing calories alone improves body weight and glucose tolerance. However, a prolonged . is necessary for many of the benefits . , including improved insulin sensitivity, reduced Alzheimer’s pathology, improved neuroprotective signaling, and improved cognition".

"Overall, our results suggest that both when and how much we eat may influence the development and progression of Alzheimer’s disease". We also have human studies demonstrating that more breaks from foods is an achievable path to better health.

Our brains on UPF diets. ". high UPF intake corresponded to extensive gray matter compromise, including reduced subcortical volumes with right-hemispheric predominance, and widespread cortical deterioration in volume, thickness, and surface area.".

Once again, the necessary change is grassroot-driven, not government-driven. This makes me hopeful.

"‘It ain’t what you don’t know that gets you into trouble. It’s what you know for sure that just ain’t so". Great quote to highlight the shortcomings of applied nutritional science.

The "high fat diet" of rodents.

The processing level of the diet matters a lot more than other factors typically emphasized by guidelines. Like dairy fat, which doesn't matter at all.

Will the misrepresentation of dietary fat ever end?

What the review on the diet-microbiota-gut-brain axis stated: "High-fat diets have been reported to alter . (microbes). potentially negatively impacting brain function" . No mention of this: .In (IL10-) mice.High-fat diets for rodents are high fat + high sugar. Sigh.

"High UPFs intake was associated with elevated levels of inflammation biomarkers in the general healthy population, highlighting the need to promote natural dietary patterns and reduce UPFs consumption".

Great work! You can lose weight on a "healthy ultra-processed diet". But more on a minimally processed. And drop the fatigue, constipation, sleep issues and infections ; ).(I know it's a lot to ask. But really hope they drew blood for nutrient analyses).