"[Chronic inflammation rising with age]. appears to be largely a byproduct of industrialized lifestyles, with major variation across environments and populations.". Looks interesting. I haven't gotten the full text yet. h/t @JoHenrich .

RT @EricTopol: Summary Table of the massive defunding of biomedical research in the United States .

RT @peterwildeford: We take it for granted today, but a single hour on the internet exposes you to more concentrated stupidity than a peas….

RT @cremieuxrecueil: Vaccination generally, the MMR vaccine specifically, thimerosal in vaccines, mercury in vaccines. None of it is ass….

Source.

Tirzepatide (circles) reduces cravings for calorie-rich foods but not fruits and vegetables. Similar to changes in food preferences that are seen with bariatric surgery.

Source:.

This chart shows the top 12 USAID focus areas that have been partially retained at the State Department after the chaotic aid cuts. These are really deep cuts to lifesaving and security-enhancing programs.

RT @ScottAppliedSci: Can you really reverse type-2 diabetes just by losing weight?. A new Lancet meta-analysis of 22 global RCTs says a cle….

RT @StephenORahilly: So shocking to see the USA killing the goose which has laid so many of its golden eggs. NIH supported research and the….

Instant Pot finally died after 13 years. Got a new one immediately.

RT @NewsfromScience: Breaking news: Staff at the National Institutes of Health have issued a declaration calling on their director to depol….

Has anyone used sibling controls in nutritional epidemiology to see how much genetics impacts diet-disease associations?. I couldn't find much via LLMs. I'm guessing there is genetic confounding.

I've long thought there was probably a lot of confounding in this association, but it's turning out to be larger than I expected.

"This suggests that fitness levels and mortality risk are influenced by strong socioeconomic, genetic, and behavioural confounding factors that differ between more fit and less fit people.".

Key findings:. -Size of the association is reduced by using sibling controls, which partially controls for genetics. -Fitness is also strongly associated w accidental death, not just death from cardiometabolic disease, implying confounding.-Sib controls don't eliminate this.

More evidence that the strong correlation between physical fitness and risk of death is heavily confounded by genetics and other factors. This is a tough one for the preventive health community (including me)!

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Insulin level (fasting or post-meal) isn't a reliable predictor of fat gain in observational studies. If we argue that the expected correlation is obscured by confounding, that's a de facto admission that insulin secretion isn't the primary cause of fat gain.