Brendan D. Manning
@Manning_BD
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Scientist at the interface of cell signaling and metabolism, with relevance to cancer, metabolic and neurologic diseases, and aging. @MET_HSPH @HarvardCellBio
Boston, MA
Joined December 2017
First time posting in about two years. I am out here! You will find me as BDManning on Bluesky. Hope to see you all there.
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RT @ChristofkLab: Delighted to share a recent discovery spearheaded by Blake Wilde on purine salvage pathway dependence in FH mutant tumors….
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RT @NBA: DERRICK WHITE SENDS THE EAST FINALS BACK TO BOSTON FOR GAME 7!. HE WINS IT FOR THE CELTICS AT THE BUZZER 🚨. #TissotBuzzerBeater |….
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RT @MET_HSPH: Recent work by @KaceyPrentice, and fellow researchers demonstrate that secretion of FABP4 from adipocytes can be induced thro….
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Too cool! Congrats Bart and company. Wheels are already turning on the possibilities. .
The UCL-TRO-1938 PI3Kalpha activator will soon be available from CancerTools @CancerToolsOrg Cat. #161068
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Two PhDs in the same year (#s 9 and 10)! It was a true privilege to mentor Molly @Molly__McNamara and Sophie over these last few years. Inspiring pair with the brightest of futures.
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RT @Gerta_Hoxhaj: Thank you @NatMetabolism for highlighting my scientific journey! I am grateful to my mentors, friends, and colleagues I’….
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So great to be at the Cold Spring Harbor meeting on Metabolic Signaling with my colleagues @YCormerais and Sam Lapp. Great science, good times!
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RT @LAMFoundation: Did you know that 400 million people worldwide are affected by a rare disease? This article from the NIH Director’s Blog….
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RT @ghotamis: Anyone who wish to contribute to the disaster assistance funds can use the information below. In addition, search and rescue….
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RT @RichPossemato: I am pleased to share new work out in @NatMetabolism, the Magnum Opus of former PhD student Josh Shin! Josh wanted to un….
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RT @HarmonyTurk: Check out the final issue of @CR_AACR for 2022. Great reading material for any upcoming holiday travel!.
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Lysosome-dependent turnover of membrane phospholipids providing a means to recycle fatty acids at a time when mTORC1 and SREBP-mediated de novo synthesis of fatty acids is attenuated. Still do not know the precise molecular mechanism, but involves membrane delivery to lysosomes.
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Aaron used unbiased lipidomics to determine what happens to intracellular lipid species when mTORC1 is inhibited and landed on an observation similar to that reported previously by @OlzmannLab - however the changes we see do not depend on autophagy.
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Thanks Mathieu! Looking forward to reading your perspective on the study.
I am happy to share our News and Views published today in @NatMetabolism. In this article, @LauTribouillard and I discuss exciting new findings from the @Manning_BD’s lab.
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If any scientists are left on this platform, it is my pleasure to share the work of Aaron Hosios from our group, who found that mTOR inhibition leads to phospholipid catabolism and adaptive repurposing of the fatty acids for energy storage or production.
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Truth-oblivious, rumor-mongering toxicity notwithstanding, the potential loss of this venue to communicate and celebrate science and the joy of being a scientist is sad.
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