Andrew Robinson
@MBB_Andy
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Manager of Manchester Brain Bank (@MancBrainBank) and researcher in the neuropathology of ageing and neurodegenerative disease. Views are my own.
Joined July 2017
Our latest collaborative paper suggests long-term intellectual engagement, particularly in academic professions, may offer benefits for cognitive aging. https://t.co/kECn6FaWRh
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Check out our recent paper in @braincomms: C9orf72 dipeptides activate the NLRP3 inflammasome šš»šš»šš» With @choyle22, @mere_conjecture, @ComorbidCath, @DNS_UOM, @GJBrainResearch & funded primarily by @AlzSocResearch
Rivers-Auty et al., find that C9orf72 dipeptides cause neuroinflammation in frontotemporal dementia and amyotrophic lateral sclerosis, and highlight the inflammasome as a therapeutic target. Please read the full paper at: https://t.co/Spt043wEJM
@DrSarahRyan
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New paper: Our findings suggest that anti-AĪ² therapies are more effective if given before AĪ²3pE-42 deposition. https://t.co/qig00JijA4
life-science-alliance.org
The amyloid Ī² peptide (AĪ²), starting with pyroglutamate (pE) at position 3 and ending at position 42 (AĪ²3pE-42), predominantly accumulates in the brains of Alzheimerās disease. Consistently, donane...
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New publication - Depression in older adults and its associations with sleep and synaptic density. https://t.co/465UvMJvMH [ https://t.co/xscvm01DYj]
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Another interesting clinico-pathological case study using tissue from @MancBrainBank
https://t.co/TbI0r8As6I
movementdisorders.onlinelibrary.wiley.com
Background Corticobasal syndrome is a clinical diagnosis and common pathological causes are corticobasal degeneration, progressive supranuclear palsy and Alzheimer's disease. Objectives We would l...
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New paper alert! Blocking Hippo to boost cognition:
science.org
Blocking its sequestration by Hippo pathway kinases shifts WWC1 to neuroreceptors that promote learning.
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Donāt miss this weekās issue of #ScienceSignaling! Experiments in mice suggest that a neuron-supporting factor could be a promising target in depression, scientists discover a new approach that boosts memory in models of Alzheimerās disease, and more. https://t.co/Pid6HOubw8
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**NEW PAPER ALERT** Delighted for the first work from the Pickās disease International Consortium (PIC) to be published in Lancet Neurology.. (1/12)
thelancet.com
The Pick's disease International Consortium provides an opportunity to do large studies to enhance our understanding of the pathobiology of Pick's disease. This study shows that, in contrast to the...
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Tissue from Manchester Brain Bank was utilised in this very important study https://t.co/501kUSGIVc
thelancet.com
The Pick's disease International Consortium provides an opportunity to do large studies to enhance our understanding of the pathobiology of Pick's disease. This study shows that, in contrast to the...
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Self-reported late-life hypertension is associated with a healthy cognitive status and reduced Alzheimer's disease pathology burden: https://t.co/IM8i0xM5wz
pubmed.ncbi.nlm.nih.gov
Our findings suggest that late-life hypertension is associated with less severe AD pathology. We postulate that AD pathology may be promoted by reduced cerebral blood flow.
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Great to have been involved in this important work led by @jakobhartmann28Ā andĀ @GassenNils. https://t.co/lIvRBvmd2h
nature.com
Nature Communications - Secretory autophagy (SA) plays a crucial role in neuroinflammation-driven neurodegeneration, through SKA2 and FKBP5. SKA2 regulation of SA can inhibit IL-1Ī² release....
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Very proud that my daughter is involved in this great initiative
Our Varsity Academy programme continued today for students from @HathershawC @saddleworth_sch @TheRadclyffe and @OasisLeesbrook ā ā We hope you enjoyed your second day of sessions at OSFC!ā ā #WeAreOSFCā
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Our Varsity Academy programme continued today for students from @HathershawC @saddleworth_sch @TheRadclyffe and @OasisLeesbrook ā ā We hope you enjoyed your second day of sessions at OSFC!ā ā #WeAreOSFCā
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My first ever research paper is out !! š©š¼āš¬š šš https://t.co/GoDwQC3MwO A natural product "brazilin" inhibits the NLRP3 inflammasome pathway, a key driver of numerous inflammatory human diseases including those affecting the brain such as stroke and dementia.
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Apolipoprotein-E genotyping in formalin-fixed and paraffin-embedded post-mortem brain tissue #neurodegeneration
https://t.co/if0xsVeseh
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Latest paper from the team at MBB! ApolipoproteināE genotyping in formalināfixed and paraffināembedded postāmortem brain tissue
onlinelibrary.wiley.com
Formalin-fixed paraffin-embedded brain tissue held in tissue banks constitutes a valuable research resource, especially when associated with clinical annotations and longitudinal psychometric...
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Congratulations to @MinshNeuro on his first 'first author' paper!
Proud to share my first first-name paper! It's been a long time coming. @MancBrainBank ApolipoproteināE genotyping in formalināfixed and paraffināembedded postāmortem brain tissue - Minshull - Brain Pathology - Wiley Online Library
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The countdown is on to the Jeff Showcase 2024! We're really looking forward to welcoming everyone this Friday at Hyatt Regency Manchester. All the details, from venue to programme can be found here: https://t.co/LNVQ9PoU5D See you there! #Jeffshowcase2024
eventbrite.co.uk
A showcase of the pioneering research happening in the centre.
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