danny hsu
@asibc512
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Joined May 2013
RT @Saritapuri24: Good start of year 2025 with the last publication from my postdoc work where we dissected the role of individual domains….
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RT @Saritapuri24: Combining SAXS, MD simulations and HDX-MS, we identified a new conformational (H) state in AL LCs. This state could be a….
elifesciences.org
Computational modeling and in vitro experiments identify a unique conformational state in amyloidogenic light chains, providing a structural basis for amyloidosis and a precise target for drug design.
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Very pleased to know that our recent work on hCoV-229E S:hAPN recognition has been highlighted by Nature Communications alongside the work of the newly minted Nobel Prize laureate David Baker
lnkd.in
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RT @erhminlai: We are thrilled to welcome @MakotoShirakaw2 joining @IPMBSinica as a new PI in this fall. Look forward to exciting research….
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RT @IPMBSinica: @IPMBSinica summer undergraduate internship program is now open for applications!. 🔗 Apply here: 📆….
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We used cryoEM and mass spectrometry glycoproteomics plus GlycoSHIELD to determine the molecular structure of human coronavirus 229E spike protein in complex with its human receptor, hAPN in a 6:2 binding stoichiometry.
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@PDraczkowski Here is a more dynamic view of how the K11/K48-branched ubiquitin chain is recognized by the proteasome .
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Here is how the K11/K48-branched ubiquitin chain looks like on the 26S proteasome. And a K11-K48 alternating linkage from proximal ubiquitin! Kudos to @PDraczkowski
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Our preprint on the first glimpse of how the human proteasome recognizes a K11/K48-branched ubiquitin chain is out. This work reveals a new multivalent ubiquitin binding mode by the proteasome that could serve as priority checkin signal for proteolysis.
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RT @tecro_ksa: The 2024 Franco-Taiwanese Scientific Grand Prize was presented to Danny Shang-te Hsu, deputy director of the Institute of Bi….
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RT @Saritapuri24: Happy to share our work on conformational states of amyloidogenic light chains published as preprint in eLife https://t.c….
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RT @Saritapuri24: Check out our latest invited review published in @FrontiersIn Biophysics explaining why dynamics in deubiquitinase (DUBs)….
frontiersin.org
Ubiquitin C-terminal hydrolases (UCHs) are crucial enzymes within the ubiquitin-proteasome system, characterized by a characteristic Gordian knotted topology...
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RT @IBCSinica: AI systems capable of #protein structure prediction and protein drug design won #NobelPrize2024 Prize in Chemistry. IBC pr….
smctw.tw
今（2024）年的諾貝爾化學獎，由大衛．貝克（David Baker）、德米斯．哈薩比斯（Demis Hassabis）和約翰．瓊珀（John M. Jumper）獲得殊榮，貝克成功創造了全新類型的蛋白質，而哈薩比斯和瓊珀開發了一種人工智慧模型來解決預測蛋白質複雜結構的問題。台灣科技媒體中心邀請四位專家解析研究重要性。
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RT @IBCSinica: 🔬Publication - by @asibc512 @jbiolchem . This study reveals the structure and interaction of #ZFAND1 and #p97, providing a b….
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CryoEM workshop at @AcadSinica by @KPWu11 from @IBCSinica 100 participants for a whole day of ultra-cool stuff.
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RT @IBCSinica: 🔬Publication - by @asibc512 @khooAS @CellCellPress .By using glycoSHIELD, a #reductionist method that reveals the structure….
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Chronicle of GlycoSHIELD in German :) Zelloberfläche: Wechselwirkungen lassen sich einfacher simulieren.@cyril_hanus @BioPhysMatt @IBCSinica @AcadSinica.
deutschlandfunk.de
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Sugar coating of membrane proteins has been the Emperor’s New Clothes for structural biologists due to the intrinsic dynamics. Kudos to team @BioPhysMatt @cyril_hanus we now have GlycoSHIELD .in Cell to aid visualization of glycans.
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RT @BioPhysMatt: 🔥🔥🔥Thanks @cyril_hanus this was a wild ride! congrats to all co-authors, amazing support from @MCB_UJ, @MPIbp, @HummerLab….
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