David Langlais
@LanglaisLab
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research lab in immunogenomics at #McGill, studying genetics and functional genomics of immunodeficiencies, infectious and autoimmune diseases. #LanglaisLab
Joined July 2013
1/ We report @ImmunityCP that the PD-1:PD-L1 axis promotes the development of B-cell memory and antibody responses in mice and humans. To our surprise, the pro-B-cell effect of PD-1 and PD-L1 is, at least partially, mediated in a B-cell-intrinsic manner. https://t.co/bUQetIShiF
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Protestation mondiale contre la fermeture de VEuPathDB
It appears #NIAID will shutter the genome data base we all use daily. This strikes me as a significant mistake that may well endanger much of our global progress. @BSPparasitology @AS_Para @ASTMH @TrendsParasitol @AmSocParasit @parasitesrule @PiParasitology
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🎉Congratulations to @LanglaisLab and Michel L. Tremblay from @mcgillu for their award from @GenomeQuebec for their project "Establishing therapeutic cord blood-derived NK cells for hard-to-treat cancers through omics based and pharmacological activators"
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What a great way to start our Single Cell Education Workshop @SingleCellClubM ! Look forward to see the community later tonight at our “Get Clean, Or Get Lost” scQC Discussion hosted by @michaelluo @theresawonder @LanglaisLab !!
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Fundraising for the Canadian Pulmonary Fibrosis Foundation to support pulmonary fibrosis research on behalf of the McGill Against PF Team:
p2p.onecause.com
Aidez-nous à lever des fonds pour CPFF! L'équipe multi-disciplinaire de recherche sur les maladies pulmonaires interstielles et la fibrose pulmonaire de l'Université McGill, participeront à la marche...
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Thrilled that our project is funded!! My lab and Dr Michel Tremblay's lab partner with Kanyr Pharma and the MUHC Cell Therapy Lab (Drs Pierre Laneuville and Linda Peltier) to establish therapeutic cord blood-derived NK cells for hard-to-treat cancers. @mcgillu @McGillGenome
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Attend the Single Cell Discussion about “Quality Control of Single Cell Data - Get clean or get lost”. The seminar will be about quality control parameters of SC sequencing data including sample preparation, ambient RNA, and doublet detection. Details in the poster below.
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Out in @CellCellPress today! We describe the first humans with inherited, complete FLT3L deficiency. Despite a lack of most dendritic cells, they reached adulthood. See the thread below for the main highlights of our paper.
cell.com
Adult humans with inherited, complete FLT3L deficiency enable valuable insights into the role of the hematopoietic growth factor FLT3L in human hematopoiesis, revealing that FLT3L deficiencies impair...
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Dear SC community. Join us on April 24th, 9am for a special session with @ParseBio at our single cell monthly seminar. Link on our website. https://t.co/HSheYiTvnY
@TheNeuro_MNI @LabStratton @LanglaisLab
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You can read our latest paper :) A comment on: Extracellular Vesicles: Translational Agenda Questions for Three Protozoan Parasites. Published in Traffic - Wiley Online Library
onlinelibrary.wiley.com
The framework summarises the potential translational utilities of extracellular vesicles in Plasmodium falciparum, Leishmania spp. and Trypanosoma cruzi. It highlights three strategic questions to...
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Dear SC community. We have officially opened registration for our 2024 Single cell RNA sequencing workshop! When: June 6th-7th 2024 Registration is free at https://t.co/HSheYiTvnY. The final agenda of the workshop will be provided soon @TheNeuro_MNI @LabStratton @LanglaisLab
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Congratulations @Tangye_Lab Thanks for having invited us to participate in this important study!
What does human CD4 do? By studying 7 ppl from 5 families with pathogenic homozygous CD4 mutations, our latest work by @GuerinAntoine6 @GarvanInstitute @UNSWMedicine describes non-redundant functions of CD4 in human immunity. https://t.co/mzjbiFjE49
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🚨 Job opportunity, please RT! 🚨 My lab in Kyoto 🇯🇵 is looking to recruit 2 postdocs to work on comparative epigenomics, transposable elements, and/or related topics. Come work with @TakaInoue5 and me @Ashbi_KyotoU ! https://t.co/5uW5VT4Vs4
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C'est demain! Qui d'autre a hâte? 🍻 It's tomorrow! Who else is excited? 🎉
The next MIM happy hour will be on March 19 at Pub l'Île Noire! See below for details 🍻 Le prochain 5 à 7 de MIM sera le 19 mars au Pub l'Île Noire! Voir ci-dessous pour plus de détails
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The next MIM happy hour will be on March 19 at Pub l'Île Noire! See below for details 🍻 Le prochain 5 à 7 de MIM sera le 19 mars au Pub l'Île Noire! Voir ci-dessous pour plus de détails
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Another amazing discovery from @BeziatV team in @casanova_lab. The 1st humans with inherited pre-TCRalpha deficiency, published in @ScienceMagazine. Grateful that my lab participated in this study! @mcgillu @McGillGenome
1/ Just in! We report the first humans with inherited pre-TCR⍺ deficiency in @sciencemagazine. Dive into our fascinating findings on complete and partial forms of pre-TCRα deficiencies, including a common variant in the Middle East and South Asia.
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1/ Just in! We report the first humans with inherited pre-TCR⍺ deficiency in @sciencemagazine. Dive into our fascinating findings on complete and partial forms of pre-TCRα deficiencies, including a common variant in the Middle East and South Asia.
science.org
Functional αβ T cells and late-onset immunological conditions occur in humans with rare or common inherited pre-TCRα deficiency.
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Dear Single Cell community! We are really excited for Dr. Iain Clark’s Killan lecturer talk. If you share the same interest in this GREAT single cell event, please register via QR code to attend in person or via Zoom. @TheNeuro_MNI @LabStratton @easchurr @LanglaisLab @RIMUHC1
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Dear SC community Join us tomorrow Jan 31st, 9am EST for Dr Yue Li talk on Single-cell deconvolution by machine learning approaches. Zoom link available via our website at https://t.co/vcsWRtqZyT.
@TheNeuro_MNI @LabStratton @easchurr @LanglaisLab
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🔬 Day 1 of our #ParasiteEV series: Introduction to Extracellular Vesicles (EVs) in Parasite Biology. EVs, crucial for cellular communication, play pivotal roles in parasites. Let’s unveil their mysteries! 🦠🧫 #ScienceTwitter #EVs #ISEV (1/4)
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