Minguet_lab
@LabMinguet
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Joined January 2020
T cell friends! CAR T cell aficionados! Here a quiz for you! The TCR have four signalling chains, the CAR uses only one, which one do you think will perform best?
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Un autentico honor y un placer volver a Majadahonda. Aquí hice mi tesis doctoral, aquí nació la semilla de la investigación, y ahora volver cierra un emotivo circulo. Gracias a la SICAM por la invitación.
Los Ponentes de las XIII Jornadas Científicas SICAM
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@KirOxford Had a great visit to the Kennedy Institute at Oxford yesterday- thanks @AGerardLab for hosting me!
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On Monday 18th Nov, Dr Mahima Swamy joins us to talk about "The multiple roles of intraepithelial T lymphocytes in maintaining intestinal homeostasis". Don't miss it! Oxford Talks: https://t.co/tmzNcUxUgE
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Vamos, @RafaelNadal! As you get ready to graduate from tennis, I’ve got a few things to share before I maybe get emotional. Let’s start with the obvious: you beat me—a lot. More than I managed to beat you. You challenged me in ways no one else could. On clay, it felt like I
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Excited to read this paper on the changes in the gut upon ageing
Our new paper on the role of Age-related loss of intestinal barrier integrity on T cell ageing is published in Ageing Cell! A massive thank you to@MsMacrophage @GAnderson808 @WvSchaik @ClaudioMauro6 and amazing team @jessicaconway_
https://t.co/8P6fKAHwXn
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Congratulations Jan! What a year, your are rocking it!
Excited to share that our story on PGE2-mediated control of NK cell metastasis surveillance in lung tissue is now published in @CellReports 🤝 Thanks to the many great colleagues who helped conduct this study! 👏Congratulations to first author @AMPedde! https://t.co/fw6guDafNW
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Interesting and important.
1/10 PREPRINT MONDAY at the SchubertLab Benchmarking TCR-Epitope Predictors with ePytope-TCR ( https://t.co/I3C3JkehlQ) Short-Summary: - 18 pre-trained public methods - evaluated on 2 benchmarking datasets - for repertoire annotation & cross-reactivity prediction
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Wow, thanks Chenqi for sharing, as always, interesting, insightful and fun to read!
We are happy to publish a perspective @NatRevImmunol, focusing on a charge-based signaling motif BRS. Being widely present in immunoreceptors and other membrane proteins, BRS can regulate many aspects of immune responses. https://t.co/337Kk5RAV1
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We are happy to publish a perspective @NatRevImmunol, focusing on a charge-based signaling motif BRS. Being widely present in immunoreceptors and other membrane proteins, BRS can regulate many aspects of immune responses. https://t.co/337Kk5RAV1
nature.com
Nature Reviews Immunology - The basic-residue-rich sequence (BRS) is a common motif located in the cytoplasmic tail of most immunoreceptors. This Perspective highlights the mechanisms of BRS...
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On the way back to @UniFreiburg after the @CIBSS_UniFR review @dfg_public - after being focused on this event for months, time to be a little unfocused or shift the focus to other things.
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Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolism after eating @Nature Huge effort by @Akaron0884 & @BrennethS and the team and collaborators to work this out. Aaron's Tweetorial 👇 https://t.co/WC4ADEpvHG
nature.com
Nature - Innate IL-17-producing T cells—in particular, adipose γδ17 T cells—are enriched in molecular-clock genes, and the circadian expression of IL-17A and RORγt by...
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Our new work led by our fantastic PhD student Jose (@j__cabezas) showing dramatic reductions in TCR-T cell cross-reactivity without modifying the TCR. Part of this work relied on SPR-based @carterra_bio to measure 163 TCR/pMHC affinities within 24 hours at 37 degrees.
I am excited to share the results from my PhD project at the @Dushek lab and my first first-author manuscript! Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors. https://t.co/ZQaen3POif 🧵
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Just over 2 weeks left to apply! Our highly collaborative and interdisciplinary Cluster of Excellence is looking for a new colleague with expertise in #cryoEM #structuralbiology and #signaling
#facultypositions #professorship
🚨 #JobAlert: W3 Professorship in Physical Chemistry with a focus on Cryo-Electron Microscopy. Join the Faculty of #Chemistry and #Pharmacy @UniFreiburg and contribute to cutting-edge research in the Cluster of Excellence #CIBSS. Apply by Nov 12, 2024! 👉
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Come work with me at the @MedUni_Wien - I have a PhD position open which investigates CAR T cell downstream signaling!
#PhDCall 2024: Optimise #CARTcells like a #lego model! 🧬⤵ In one of our PhD projects, you can optimise the signalling pathways of CAR T cells - just like a lego model! Read more and apply now! ➡ https://t.co/KcWwtCcuFx
@ZajcCharlotte
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#PhDCall 2024: Optimise #CARTcells like a #lego model! 🧬⤵ In one of our PhD projects, you can optimise the signalling pathways of CAR T cells - just like a lego model! Read more and apply now! ➡ https://t.co/KcWwtCcuFx
@ZajcCharlotte
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Happy to hear your thoughts about this perspective! Do you think there is still space for further improvements?
REVIEW @NatRevImmunol From TCR fundamental research to innovative chimeric antigen receptor design https://t.co/92g5KIILSA
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Excellent review from the lab about CAR design 😍 Look inside 👀
Do you know how to design innovative CAR T cells? The TCR is an incredible inspiration and has tons to teach us! Check our latest perspective in Nat Rev Immunology: https://t.co/OX681dHXN8 You will find a new exciting way to look at CAR T cells! @CIBSS_UniFR @BUnifr @UniFreiburg
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Do you know how to design innovative CAR T cells? The TCR is an incredible inspiration and has tons to teach us! Check our latest perspective in Nat Rev Immunology: https://t.co/OX681dHXN8 You will find a new exciting way to look at CAR T cells! @CIBSS_UniFR @BUnifr @UniFreiburg
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📣 Join us for the yEFIS General Assembly on 🗓️ November 12, 2024, at 5 PM CET via Zoom. 🧑💻 ✨ Connect with over 850 young immunologists, meet our task force, and discover upcoming activities and opportunities. 🔗 Register now: https://t.co/QNLIncwqNH (limited spots available!)
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