Lauren Saunders
@LSaund11
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✨ Brand new Junior Professor @COSHeidelberg former postdoc w/ @coletrapnell. @parichylab alum dev bio | zebrafish | neural crest | single cell genomics. she/her
Heidelberg, Germany
Joined May 2012
🇩🇪🚆🏰Heidelberg offers a vibrant life sciences community with DKFZ, EMBL, and UniHD + we’re just 2 hrs from Basel and 4 hrs from Paris (by train)! Reach out if you’re curious about living in Europe - affordable childcare, 30 days vacation/yr, a walkable city, and more
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Join us! The Saunders lab is looking for postdocs, PhD students, and technicians to join our new lab at #COSHeidelberg 🐟🧬🔬🇪🇺 We’re studying neural crest lineage plasticity in fish with developmental genetics and single-cell genomics. For postdoc apps:
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We have postdoc openings related to EMBL's new "Life in Context" program. What's unique about them? Opportunities for fieldwork, learning cutting-edge single cell genomic techniques, using non-traditional model organisms, and a focus on the effects of the environment.
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And please do check out @mwdorr’s preprint which highlights how the approach can be used to study environmentally-induced phenotypic variability!
Our preprint on using single-cell sequencing to study how zebrafish embryos manage temperature stress is now online. Led by @mwdorr, with critical contributions from @lsaund11, @maddymduran, @SRsrivatsan, and David Kimelman.
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…and of course, we couldn't have done it without decades of work by the zebrafish community on the genetic perturbations we included!
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Thanks especially to the dream team I was fortunate enough to work with while generating and disentangling this giant pool of data! @mwdorr @maddymduran @RaibleLab @CeciliaMoens @coletrapnell & David Kimelman
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I'm excited to finally share my postdoc work, co-lead with my dear friend @SRsrivatsan, establishing a framework for time-resolved, multi-scale phenotyping of whole zebrafish embryos. See Cole's thread for a semi-brief digest of our findings! 🐟🧬
Our preprint on deep phenotyping of genetic perturbations of zebrafish embryos with single-cell RNA sequencing is now online. Led by @LSaund11 and @SRsrivatsan, with David Kimelman, @CeciliaMoens, @RaibleLab and @JShendure
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Are you a ⭐️molecular biologist⭐️ who wants to use single cell genomics to study how climate change affects fish development? Want to live in Europe? The Dorrity lab is hiring a Lab Officer to join our growing team! 🐟🌡🧬
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Our paper on sci-Space, a spatially resolved version of sci-RNA-seq, is out today! Led by @srsrivatsan and @mregier13, Joint work with @JShendure and @kellystevenslab. (Art by @nigelsussman)
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What a fun collab with @Andrewjohnaman! We used the power of sci-RNA-seq to profile nuclei across 4 genotypes during scale development in z-fish. Andy dug deep with live imaging, and we found some exciting new stuff about the cells involved in patterning scales and pigment!
Last up, postdoc @Andrewjohnaman and @Lsaund11 in @coletrapnell lab document the diversity of skin cell types in zfish. 8/11 https://t.co/O70hXUhtax
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Do not skip the movies in this one - Andy's heroic imaging efforts and fish resuscitation skills allowed him to track scale development over three months!
We have a new preprint out on postdoc @andrewjohnaman’s work on scale development in zebrafish, with help from @LSaund11 and undergrad Margaret Kim. 1/12 https://t.co/CkrJ33SeEE
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Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day next Friday (3/26). All talks will be live-streamed (no registration required) at https://t.co/ZYfAPcXfj7
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A bright spot in 2020! Congratulations!! I guess I picked a good day to do some CRISPR editing 🙌 #NobelPrize
BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
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We made some new zebrafish tools! We built and tested a new #zebrafish #transcriptome, which improved gene detection in #RNAseq, especially in #scRNAseq. Check out our new paper at @eLife: https://t.co/sYHNqAlrFw. My 1st "real" first author paper in almost 20 years!
elifesciences.org
Computational efforts yield a zebrafish transcriptome annotation that provides more sensitive and comprehensive gene detection over existing annotations when used for bulk or single-cell RNA-seq.
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After 1200 + commits, I am proud to announce that dynamo is now on PyPi. See how we leverage it to go beyond RNA velocity to velocity / acceleration vector fields which then power us to calculate the potential, curl, divergence, curvature of single cells. https://t.co/v5qxpORdba
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New postdoc position available in our group to study development, genetics, or evolution of adult phenotypes. We have extra $$$ after good news on 2 fellowships and 1 R01 (written w/ a postdoc to support HIS program; we have great people).
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Climate change, temperature & embryogenesis. Concurrent 9 #2020SDB Michael Dorrity @mwdorr shares his findings on how temperature stress introduces variability in embryogenesis via cell type-specific effects on developmental rate. @___SDB___
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in exciting personal news, my grad school work has been (finally) published! many thanks to @LSaund11 - an exceptional collaborator - and many other people! https://t.co/NxRtBuoSQt
pubmed.ncbi.nlm.nih.gov
Compartmentalization of macromolecules is a ubiquitous molecular mechanism that drives numerous cellular functions. The appropriate organization of enzymes in space and time enables the precise...
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