Lorenzo Ramos-Mucci, PhD
@LRamosMucci
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Senior scientist at Relation Rx. Formerly at University of Oxford. Focus on musculoskeletal biology and single-cell. Uni of Liverpool, UTwente and Yale alum.
Oxford, UK
Joined April 2013
Our latest @scTrends_update article is now in @CellGenomics: https://t.co/HRaUAjqXbP Paired with this is our end of year round up: https://t.co/faq6ASYyCY Get in touch if you want to be involved!
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Want to get involved in @scTrends_update ? Read about the #livingreview concept here:
sctrends.org
A Living Review of Commercial Single Cell and Spatial Omic Technologies
A community effort to track commercial single-cell and spatial ’omic technologies and business trends https://t.co/suvfo1IJ8m
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Have you ever wondered which single cell/spatial omic technology to use? Excited to share the scTrends Consortium's first report on single-cell and spatial genomics tech! Check out our comment in @NatureBiotech! #Genomics #Biotech #scTrends
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Today is the go live day for @scTrends_update! A consortium to both review *commercial* technologies, but also study market trends to assess angles for how technologies may differentiate themselves.
Have you ever wondered which single cell/spatial omic technology to use? There's lots of methods developed in academia, but no review of marketed products. Check the @scTrends_update ( https://t.co/aEMejm8Upm) commentary in @NatureBiotech by @wildtypehuman & @AdamCribbs
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Have you ever wondered which single cell/spatial omic technology to use? There's lots of methods developed in academia, but no review of marketed products. Check the @scTrends_update ( https://t.co/aEMejm8Upm) commentary in @NatureBiotech by @wildtypehuman & @AdamCribbs
sctrends.org
A place to hear what's going on in the world of single cell and spatial omic tech! Click to read scTrends, a Substack publication with hundreds of subscribers.
The July issue is live https://t.co/VZe8hqtMbH Our cover shows a DNA nanodevice measuring organellar sodium ion levels in lysosomes of living cells. Zou et al. developed RatiNa for imaging intracellular Na⁺ at single-organelle resolution https://t.co/P1A5ldvRNk
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We are thrilled that our paper on healthy hamstring tendons is finally out in @FASEBorg Journal! https://t.co/KHZIS5dJZR Congratulations to the amazing team that worked on this @Sarah_JB_S, @AdamCribbs, @mathewbaldwin3, @LRamosMucci, @alina_kurjan, @ClaudiaPaul3, and many more!
faseb.onlinelibrary.wiley.com
This study characterized healthy human hamstring tendon using single nucleus RNA-seq, spatial transcriptomics, and imaging. The resulting reference dataset improves current understanding of the...
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Transformers for cell segmentation in spatial transcriptomics https://t.co/gsKpyKWLqt
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Pls RT! We are hiring a senior computational biologist to work on large sc/spatial datasets of human brain cancer. High potential for career dev & long term opportunities with the lab. We are drowning in cool data & you get to look at pretty ST as a bonus https://t.co/2BRPZBzSc8
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Not very often scientists are featured in the newspaper, even if it is just a brief mention of the bone research we are doing at @RelationRx. We work hard to have a lasting impact on the patients. Check out the article on @thetimes:
thetimes.com
Twice last week, Lorenzo Ramos-Mucci received a coolbox with macabre contents: bloodied bones chilled on ice. The hips, donated by an osteoporosis sufferer wh
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We are thrilled to share our pre-print: “Single nucleus and spatial transcriptomic profiling of human healthy hamstring tendon” https://t.co/ZhbTtyuJIY
@LRamosMucci @ClaudiaPaul3 @alina_kurjan @chinychinchin_ @HulleyLab @SteveGwilym @AdamCribbs @mathewbaldwin3 @Sarah_JB_S
biorxiv.org
The molecular and cellular basis of health in human tendons remains poorly understood. Amongst human tendons, the hamstrings are the least likely to be injured or degenerate, providing a prototypic...
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The mechanism of action of LNA043, a disease-modifying #osteoarthritis treatment candidate, is characterized in preclinical studies and through transcriptomic profiling of osteoarthritis patient cartilage from a phase 1 trial #OA #NIBR @NovartisScience
nature.com
Nature Medicine - The mechanism of action of LNA043—a novel disease-modifying osteoarthritis treatment candidate—is characterized in preclinical studies and through transcriptomic...
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Our work “Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease” just published in @ScienceMagazine. The work started with the creation of the OneK1K cohort, consisting of scRNA-seq data on PBMCs from ~1000 donors https://t.co/Uzskay7TeM 🧵
science.org
Cell type and context affects gene expression affecting immune-mediated disease.
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Our latest publication is finally online!!! Well done @LRamosMucci We describe changes in histological and mechanical properties with post traumatic osteoarthritis in vivo model. @LivuniILCaMS @VersusArthritis @EithneEjc @KrisDaout @livunieng
https://t.co/sJc6IUM88J
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I'm late to the party, but wanted to share our newest perspective review on tendon transcriptomics! Learned a lot working with @PauSarmien and many thanks to @Sarah_JB_S and @DianneLittlePhD for the encouragement. https://t.co/a0JWrRAuHe
onlinelibrary.wiley.com
Tendon transcriptomics is a rapidly growing field in musculoskeletal biology. The ultimate aim of many current tendon transcriptomic studies is characterization of in vitro, ex vivo, or in vivo,...
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Hot off the press! A lot of fun to write with @Sarah_JB_S @PauSarmien @LRamosMucci - tips to navigate the challenges of human #tendon transcriptomic studies. @ors_tendon @ORSsociety @JOrthopRes
onlinelibrary.wiley.com
Tendon transcriptomics is a rapidly growing field in musculoskeletal biology. The ultimate aim of many current tendon transcriptomic studies is characterization of in vitro, ex vivo, or in vivo,...
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Congrats @PauSarmien & @LRamosMucci on publication of "Pipelines to human tendon transcriptomics" This was fun to be part of & very much a team effort with joint 1st & last authors. It's also relevant to tissues beyond tendons! @DianneLittlePhD @JOrthopRes
https://t.co/BOJsLo57vu
onlinelibrary.wiley.com
Tendon transcriptomics is a rapidly growing field in musculoskeletal biology. The ultimate aim of many current tendon transcriptomic studies is characterization of in vitro, ex vivo, or in vivo,...
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To help develop better treatments for those suffering from tendon tears, #ECR @Sarah_JB_S’s lab builds tissue atlases of the human tendon to serve as a reference so they can develop biomaterial-based treatments. #SciComm #Science
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@ndorms researchers @Sarah_JB_S, @AdamCribbs, @arthritisbham and Mathew Baldwin are building a diverse musculoskeletal atlas of healthy tissues. The work is being funded by @ChanZuckerberg
https://t.co/OWJtBrgTSI
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To say we are really excited about this funding is an understatement! We can't wait to work together to establish training & deliver ancestrally diverse atlases of musculoskeletal tissues. @AdamCribbs @CambridgeHipDoc @SAMSON_tweets @arthritisbham
https://t.co/6A59UXzL5V
ndorms.ox.ac.uk
NDORMS researchers and several international collaborators have been awarded funding from the Chan Zuckerberg Initiative to deliver an ancestrally diverse musculoskeletal atlas of healthy tissues.
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Our newest paper on murine ligaments in PTOA and mechanical changes available on BioRxiv. Congratulations @LRamosMucci
@KrisDaout @EithneEjc @LivuniILCaMS @craigk1986
The anterior cruciate ligament in murine post-traumatic osteoarthritis: markers and mechanics https://t.co/DFuiiDk50m
#bioRxiv
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