KnowlesLab Cambridge
@KnowlesLabCamb
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Interdisciplinary and interactive group of scientists working on microfluidics, protein biophysics and protein misfolding diseases.
University of Cambridge
Joined October 2016
Thanks to co-authors: @georg_meisl, @eaandrzejewska, @GeorgKrainer, @Irennn31, @giorgino83 and others.
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Our latest paper by @Catherine_k_xu.- secondary nucleation is the source of both oligomers and fibrils in Parkinson's associated a-Synuclein aggregation. Fantastic collaboration with Linse lab.@SpillantiniLab and @VendruscoloLab .
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RT @ScienceofPD: New paper from @Catherine_k_xu @KnowlesLabCamb & collaborators reports secondary nucleation as not only the key source of….
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RT @KadiLiisSaar: Our work on predicting the composition of biomolecular condensates — cellular complexes that regulate processes, such as….
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Thermodynamic insights into trigger factor broad substrate specificity - fantiastic work by Therese together with Quentin, Pavan, Tadas and @SchneiderMatth in a collaboration with Christodoulou and Cabrita groups at UCL is out now:.
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Introducing a quantitative nonspecificity score for clinical-stage antibodies - great work by Therese Herling and @HAusserwoeger in an exciting collaboration with Novo Nordisk is now published:.
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Fundamental insights into the influence of sheer forces in amyloid formation - great work by @eaandrzejewska and @mus_greta led by @Emil_Axell and others from the Linse lab is now out: .
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Check out our newest publication on creating custom architectures inside biomolecular condensates - congratulations Nadia, @DaoyuanQian219, Tomas and others together with the Weitz lab and @vanhest_lab!.
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How condensates sustain pH gradients and their potential role as emergent electrochemical microenivorenments - great work by.@HAusserwoeger, @rob_scrutton, Tomas, @CM_Fischer.and others together with @HymanLab, Alberti Lab and @novonordisk is now out:.
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Outcome of a great collaboration with @VendruscoloLab is now published! Well done @eaandrzejewska.
Super psyched to see this published at last! We demonstrate a novel approach to slowing alpha-synuclein aggregation in #Parkinsons. A massive thank you to the @VendruscoloLab, @KnowlesLabCamb, Caughey, Ghetti and Sormanni labs.
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Check out the great work of @georg_meisl and Alex!.
Check out our new PNAS paper Using a method originally developed in astronomy, we determine the half lives of all proteins in a cells, in a single set of experiments. Congrats to Alex & everyone involved on a really cool paper! @KnowlesLabCamb @PNASNews.
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Tuomas gives his inaugural talk as he takes on the position of a 1920 Professor in Physical Chemistry. Congratulations! @ChemCambridge
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RT @SupraLife_EU: Exciting start to Day 2! Tuomas Knowles, Professor & Head of the @KnowlesLabCamb at @Cambridge_Uni, kicks off the day wit….
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Check the latest work on albumin-drug conjugates! Great collaboration with Bernardes group. Well done Tuuli!
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Check our new paper on Ab42 self-replication! Well done @georg_meisl, great collaboration with @SaricLab !.
New🌶️: Amyloid self-replication occurs on small & rare “catalytic sites” on the fibril. Work of Samo, who came for @EUErasmusPlus and stayed for MS & PhD. some things take time;). Great fun with @KnowlesLabCamb @MichaelsLabETH @georg_meisl 🪩
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Congratulations to Tanu for giving a talk on her PhD work in the liquid-liquid phase separation field! #BPS2024 by @BiophysicalSoc
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Check our work on Selenium-silk antimicrobial agents! Well done Elli, @ZToprakcioglu and Akhila.
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So thrilled to share the results of an exciting collaboration with @PappulabWashU and the Hyslop lab. Congratulations @DaoyuanQian219, @HAusserwoeger and the team!.You can read more about it here:.
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Congratulations to Tomas, Nadia, @HAusserwoeger, @KadiLiisSaar, @TimWelsh_ , @DaoyuanQian219, @GeorgKrainer and @AlexBoRNA on publishing their work on the antimicrobial peptide mechanisms of action through LLPS!
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RT @SupraLife_EU: 🗣️ Tuomas Knowles, Professor & Head of the @KnowlesLabCamb at @Cambridge_Uni 🇬🇧, is a plenary speaker @#SupraLife #Second….
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