KnowlesLab Cambridge
@KnowlesLabCamb
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Interdisciplinary and interactive group of scientists working on microfluidics, protein biophysics and protein misfolding diseases.
University of Cambridge
Joined October 2016
Thanks to co-authors: @georg_meisl, @eaandrzejewska, @GeorgKrainer, @Irennn31, @giorgino83 and others
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Our latest paper by @Catherine_k_xu - secondary nucleation is the source of both oligomers and fibrils in Parkinson's associated a-Synuclein aggregation. Fantastic collaboration with Linse lab @SpillantiniLab and @VendruscoloLab
https://t.co/zlL6BgHoRR
nature.com
Nature Communications - The formation of protein aggregates is a hallmark of Parkinson’s disease, with small oligomeric species implicated as a major source of toxicity. In this work, Xu et...
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New paper from @Catherine_k_xu @KnowlesLabCamb & collaborators reports secondary nucleation as not only the key source of a-synuclein oligomers, "but also the main mechanism of aggregate formation"; The process can occur under neutral pH & ionic strength https://t.co/WZkNUIYm3m
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Our work on predicting the composition of biomolecular condensates — cellular complexes that regulate processes, such as signalling, gene expression and stress response — together with a comprehensive proteome-scale atlas is now published in @NatureComms
nature.com
Nature Communications - Biomolecular condensates help cells organise their content in space and time. Here the authors report a machine learning driven methodology to predict the composition of...
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Thermodynamic insights into trigger factor broad substrate specificity - fantiastic work by Therese together with Quentin, Pavan, Tadas and @SchneiderMatth in a collaboration with Christodoulou and Cabrita groups at UCL is out now: https://t.co/VL88Wo17fQ
science.org
The chaperone trigger factor switches to entropy-driven binding to achieve broad specificity for ribosome–nascent chain complexes.
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Introducing a quantitative nonspecificity score for clinical-stage antibodies - great work by Therese Herling and @HAusserwoeger in an exciting collaboration with Novo Nordisk is now published: https://t.co/Bp0DcDAVz9
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Fundamental insights into the influence of sheer forces in amyloid formation - great work by @eaandrzejewska and @mus_greta led by @Emil_Axell and others from the Linse lab is now out: https://t.co/C97itZnErZ
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Check out our newest publication on creating custom architectures inside biomolecular condensates - congratulations Nadia, @DaoyuanQian219, Tomas and others together with the Weitz lab and @vanhest_lab! https://t.co/x3tZPlA61k
nature.com
Nature Chemical Engineering - Biomolecular condensates can contain multiple phases. The number of droplets of each phase and their location give the condensate a certain architecture. Here the...
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How condensates sustain pH gradients and their potential role as emergent electrochemical microenivorenments - great work by @HAusserwoeger, @rob_scrutton, Tomas, @CM_Fischer and others together with @HymanLab, Alberti Lab and @novonordisk is now out: https://t.co/5oGGivhG6A
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Outcome of a great collaboration with @VendruscoloLab is now published! Well done @eaandrzejewska.
Super psyched to see this published at last! We demonstrate a novel approach to slowing alpha-synuclein aggregation in #Parkinsons. A massive thank you to the @VendruscoloLab, @KnowlesLabCamb, Caughey, Ghetti and Sormanni labs. https://t.co/fHWtkA6eXw
https://t.co/sGUPDzMUPU
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Check out the great work of @georg_meisl and Alex!
Check out our new PNAS paper https://t.co/4QXOlMuNud Using a method originally developed in astronomy, we determine the half lives of all proteins in a cells, in a single set of experiments. Congrats to Alex & everyone involved on a really cool paper! @KnowlesLabCamb @PNASNews
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Tuomas gives his inaugural talk as he takes on the position of a 1920 Professor in Physical Chemistry. Congratulations! @ChemCambridge
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Exciting start to Day 2! Tuomas Knowles, Professor & Head of the @KnowlesLabCamb at @Cambridge_Uni, kicks off the day with a captivating talk on “Functional artificial materials through self-assembly of natural peptides and proteins”. #SupraLife #SecondSchool #ConferenceDay2
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Check the latest work on albumin-drug conjugates! Great collaboration with Bernardes group. Well done Tuuli!
pubs.acs.org
Targeted drug delivery approaches that selectively and preferentially deliver therapeutic agents to specific tissues are of great interest for safer and more effective pharmaceutical treatments. We...
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Check our new paper on Ab42 self-replication! Well done @georg_meisl, great collaboration with @SaricLab !
New🌶️: Amyloid self-replication occurs on small & rare “catalytic sites” on the fibril. Work of Samo, who came for @EUErasmusPlus and stayed for MS & PhD...some things take time;). Great fun with @KnowlesLabCamb @MichaelsLabETH @georg_meisl 🪩 https://t.co/P55qFpSB16
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Congratulations to Tanu for giving a talk on her PhD work in the liquid-liquid phase separation field! #BPS2024 by @BiophysicalSoc
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Check our work on Selenium-silk antimicrobial agents! Well done Elli, @ZToprakcioglu and Akhila.
pubs.rsc.org
Antimicrobial resistance is a leading threat to global health. Alternative therapeutics to combat the rise in drug-resistant strains of bacteria and fungi are thus needed, but the development of new...
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So thrilled to share the results of an exciting collaboration with @PappulabWashU and the Hyslop lab. Congratulations @DaoyuanQian219, @HAusserwoeger and the team! You can read more about it here: https://t.co/4I0lpqIfjD
biorxiv.org
Bio-molecular condensates formed in the cytoplasm of cells are increasingly recognised as key spatiotemporal organisers of living matter and are implicated in a wide range of functional or patholog...
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Congratulations to Tomas, Nadia, @HAusserwoeger, @KadiLiisSaar, @TimWelsh_ , @DaoyuanQian219, @GeorgKrainer and @AlexBoRNA on publishing their work on the antimicrobial peptide mechanisms of action through LLPS!
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🗣️ Tuomas Knowles, Professor & Head of the @KnowlesLabCamb at @Cambridge_Uni 🇬🇧, is a plenary speaker @#SupraLife #SecondSchool!🤩 Tuomas will elucidate the molecular mechanisms & dynamics of protein aggregation to generate biofunctionality & understand neurological disorders!
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