Hannes Ausserwöger
@HAusserwoeger
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Protein interactions and assembly. PhD, @KnowlesLabCamb
Joined October 2021
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates: Cell
cell.com
Stress granules promote TDP-43 aggregation via intra-condensate demixing, a pathway triggered by its up-concentration and oxidation within condensates. Blocking this demixing pathway prevents TDP-43...
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Excited by the possibility of proteins being able to generate distinct pH microenvironments without needing mebrane enclosure, active transporters or energy input! @KnowlesLabCamb
How condensates sustain pH gradients and their potential role as emergent electrochemical microenivorenments - great work by @HAusserwoeger, @rob_scrutton, Tomas, @CM_Fischer and others together with @HymanLab, Alberti Lab and @novonordisk is now out: https://t.co/5oGGivhG6A
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Check our latest work on studying the mechanism of action of phase separation modulators by characterising partitioning. Great work by @HAusserwoeger, @DaoyuanQian219, @GeorgKrainer, @TimWelsh_ with #StGeorgeHyslopLab @HymanLab #AlbertiLab @PappulabWashU. https://t.co/ynrdRlijkO
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Transformational insigshts into investigating multi-component systems in the new preprint by @DaoyuanQian219, @HAusserwoeger and Tomas Sneideris in a fantastic collaboration with @PappulabWashU: https://t.co/9QqixJVQ9g
biorxiv.org
Binary phase separation with conserved order parameters is a generic thermodynamic process that arises in different contexts. One system of great fundamental and practical interest is the condensat...
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Check out our new work in @PNASNews on how surface patches control protein binding specificity: https://t.co/JdOHnQRp1N Great work by @HAusserwoeger, @GeorgKrainer, @TimWelsh_, @ElladeCsillery, Tomas, @SchneiderMatth and Therese in collaboration with @novonordisk and @CCG_MOE.
pnas.org
Nonspecific interactions are a key challenge in the successful development of therapeutic antibodies. The tendency for nonspecific binding of antib...
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Magic bullet or generic sticker? Find out about antibody non-specificity in our recent work in @NatRevChem!
While antibodies have a remarkable track record in therapeutics, achieving sufficient specificity remains an issue. A Review in @NatRevChem discusses the physicochemistry of non-specificity and outlines future opportunities to improve protein binding. https://t.co/Z2NqrgPpvp
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Non-specificity as the sticky problem in therapeutic antibody development https://t.co/YfS80Ormmt A Review from Tuomas P. J. Knowles, Nikolai Lorenzen and co-workers. @HAusserwoeger @SchneiderMatth @KnowlesLabCamb @ArosioLab_ETH @ChemCambridge @ETH_en @novonordisk
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One of the more interesting reads you will come across today!
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Really excited to share our work on the fundamentals of non-specific binding in antibodies and the transition of molecular binding events to phase separation. Thanks to everybody involved! @KnowlesLabCamb @biorxivpreprint @novonordisk #targetspecificity #drugdiscovery #LLPS
Check out our preprint discovering DNA-induced LLPS of antibodies based on surface patch driven non-specific interactions: https://t.co/VrHFHnYOun Great work by @HAusserwoeger, @GeorgKrainer, @TimWelsh_, Tomas, @SchneiderMatth & Therese. Exciting collaboration with @novonordisk
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