Dr. Cheryl Keller @cherylkeller.bsky.social
@KellerCaponePhD
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Director, Genomics Research Incubator at PSU, DNA 🧬sequencing, gene regulation. Triathlete, #TeamZoot #novid
State College, PA
Joined August 2011
Anyone want to see the inside of one of these NextSeq 2000 reagent cartridges? 🙋‍♀️🙋🙋‍♂️
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🔬Simplified breakdown of the Decode ME results: DecodeME identifies 8 gene regions linking immune response, mitochondrial energy control, and brain-cell signalling to ME/CFS Genomic evidence the disease is biological. Let’s breakdown everything in depth 🧵
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Just realizing that "TTAM" in TTAM Research Institute, a non-profit founded by Anne Wojcicki, stands for Twenty Three And Me. Lol
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Our NIH grant to discover coronavirus antiviral meds was terminated today. With this grant, we had developed a better SARSCoV2 inhibitor than Paxlovid, and we recently discovered an improved drug that looks better than Pfizer's own second-generation inhibitor.
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Strong article from Tom Maniatis, head of the NY Genome Center, on the history of the NIH and its role in maintaining U.S. scientific leadership. Safeguarding the future of biomedical science in the United States: Cell
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Having served as a Moscow correspondent in the early days of Putin's reign, this reminds me of how the Kremlin took over its own press pool and made sure that only compliant journalists were given access.
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Plasma protein and brain structural imaging evidence that #SARSCoV2 is associated with greater brain β-amyloid pathology in older adults, particularly those hospitalized or with hypertension. https://t.co/CwY7tOYceR
@NatureMedicine a matched @uk_biobank case-control study
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Nicholas Winton helped 669 Jewish children escape the Nazis. His efforts went unrecognized for 50 years. Then in 1988, while sitting as a member of a TV audience, he suddenly found himself surrounded by the kids he’d rescued, now adults. I like to remember this every Jan 27th.
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“That’s when they suspended the constitution. They said it would be temporary. There wasn’t any rioting in the streets. People stayed home, watching their televisions, looking for direction. There wasn’t even an enemy you could put a finger on.” - Margaret Atwood, Handmaids Tale
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NIH appears to have canceled/postponed all of its study sections—the independent review panels that approve federal grants for health research. Such grants fund the work/salaries of 300k people at more than 2,500 institutions
Trump blocks NIH review. I’m on a study section to review cancer grants but received this email today: NIH has paused all communication, as directed by the new administration (e.g. https://t.co/KD9vnuN3ac  ), and that apparently includes a pause for all study section meetings
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Trump blocks NIH review. I’m on a study section to review cancer grants but received this email today: NIH has paused all communication, as directed by the new administration (e.g. https://t.co/KD9vnuN3ac  ), and that apparently includes a pause for all study section meetings
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Looking at bioinformaticians’ profiles these days, you'd think everyone has decades of experience in cutting-edge single-cell and AI-driven bioinformatics. But something’s missing… 👇
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VIDEO CORRECTION: We compare footage from eight months apart showing the destruction caused by wildfires in Los Angeles. We will delete an earlier version that said the videos were shot 10 months apart https://t.co/C3uTVqrazP
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It’s inspiring seeing mask blocs & covid cautious organizations working to ensure everyone in California has access to respirators. This is made possible because the disability & Covid communities never gave up on clean air & masking The government should take a cue from them.
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I had ZERO research experience as an undergrad. I was the first one of my grad school cohort to defend my PhD thesis, won an outstanding dissertation award, got a F32 as a postdoc, and am now the Director of the Genomics Research Incubator at PSU.
Here's the thing. We have **NO IDEA** how to pick good graduate students. I served on admission committees for 10+ years, and chaired a few, and what I learned is that all the spreadsheets of grades and test scores and recommendations and essays and publications and interview
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The primary issue to me is that extensive lab experience with publications or at least the prospect of them has become a de facto prerequisite for molecular biology PhD programs. This was not true when I applied to graduate school, nor was it true even when I became a PI.
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Fiber makes short chain fatty acids, we affects health. Our paper showing how this works (in part) at the level of gene expression is out: https://t.co/Nk2hs7ld8S
nature.com
Nature Metabolism - Nshanian et al. investigate the differential effects of the short-chain fatty acids propionate and butyrate on chromatin remodelling and gain insight into the mechanisms that...
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.@PennStateFball student tickets for the Orange Bowl will be free, courtesy of @tacobell. Students can request their tickets from now until 5 p.m. on Thursday, January 2. https://t.co/a7CDxG9kR2
onwardstate.com
The deadline to request student tickets is 5 p.m. on Thursday, January 2.
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Dear friends and colleagues, I'm excited to share that in 2025 I will open my new lab at @PennMedicine, @PennGenetics and the RNA innovation center. looking forward to be doing cutting-edge science with great colleagues!
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I find it concerning we know of at least 3 persons who have had #H5N1 and don't know the source - The person from #Missouri who was admitted to the hospital - The teenager in #Canada who is in critical care - The child in #California It seems we are missing something and need
California's Dept of Public Health reports a #birdflu case in a child with no known contact with infected animals. They're looking into a possible wild bird exposure. Oddly, the press release doesn't stipulate which type of bird flu (there are many). I'm assuming #H5N1. Specimen
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