Kavya Smitha Pillai
@KavyaSmitha
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Take a break from doomscrolling and read up on everything you ever wanted to know about Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics. Fun writing this with @ColinSwenson, Guna and Debbie in my lab! https://t.co/nJWJu3GyZY
pubs.acs.org
The development of potent, specific, and pharmacologically viable chemical probes and therapeutics is a central focus of chemical biology and therapeutic development. However, a significant portion...
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The Ray Moellering Lab, in partnership with @UChicagoPME & @UChicagoMed, have developed a novel way to analyze individual cancer cells. Featured on the cover of @ScienceAdvances, their new study uses single-cell chemoproteomics to identify a 6-enzyme activity signature linked to
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So thrilled to have this paper published. Grateful to all the authors for their contributions and insights!
Our recent work in automated, single-cell chemoproteomics to profile protein activity signatures in cancer w/ @SavasTay_UChi ‘s lab and colleagues @UChiChemistry @UChicagoPME @UChicagoMed
https://t.co/rIYzPneZmS
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Check out this cool paper from my colleagues!
Photoproximity profiling of native integrin “social networks” on cancer cells/tissues. We’ve long been fascinated by these important and dynamic adhesion receptors and how they do their job and who they do it with. No Abs or genetic constructs needed!
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Today in @natchembio we share a new strategy to design fully synthetic “artificial” bZIP family transcription factors that directly block DNA binding of HIF1a and XBP1 to inhibit hypoxia-dependent oncogenic signaling in cells and in vivo. 1/n https://t.co/1xIyfjbw0O
nature.com
Nature Chemical Biology - Qiao and Nguyen et al. describe a strategy to block hypoxia-dependent gene expression in cell and mouse models of breast cancer through dual targeting of X-box-binding...
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The Moellering Lab has published research in @BiochemistryACS that provides "definitive evidence that recombinant DJ-1 produced in human cells prevents the stable glycation of other proteins through the conversion of methylglyoxal" #Parkinsons Read -
pubs.acs.org
The protein PARK7 (also known as DJ-1) has been implicated in several diseases, with the most notable being Parkinson’s disease. While several molecular and cellular roles have been ascribed to DJ-1,...
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New research from @JohnCoukos @rmoellering14 & @UChiChemistry colleagues reports the stereospecific conversion of methylglyoxal to l-lactate by #Parkinsons-associated DJ-1 in solution with negligible or no contribution of direct protein deglycation https://t.co/masNFvqewH
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Identification of 24 proteins with conserved extracellular-vesicle-sorting abilities paves the way for EV-based engineering. #NBThighlight
nature.com
Nature Communications - Extracellular vesicles are naturally occurring nanoparticles that are gaining ground as delivery modalities for therapeutics. Here, the authors conducted a large-scale...
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Check out our review on spatial chemoproteomic probes, methods and applications in Wolf Prize special issue organized by @StephanHacker2 and Eranthie Weerapana. Written by @ColinSwenson, @KavyaSmitha & A. Carlos.
onlinelibrary.wiley.com
Functional regulation of cell signaling through dynamic changes in protein activity state as well as spatial organization represent two dynamic, complex, and conserved phenomena in biology. Seeming...
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our latest work in #metabolism & #PTMs by @JohnCoukos @KavyaSmitha presents a global proteomic profile of reversible Cys mods by the glycolytic metabolite methylglyoxal. Dataset presents a unique view of reactivity, structure and function in metabolism
pubs.acs.org
Methylglyoxal (MGO), a reactive metabolite byproduct of glucose metabolism, is known to form a variety of posttranslational modifications (PTMs) on nucleophilic amino acids. For example, cysteine,...
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Safety protocols in our lab include unusual instructions - like, never leave the mesh windows open. Temperatures are rising as summer approaches and our lab is seeing the regular visitors. Never a dull moment in the lab :)
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Old news by now but excited that my colleagues Chuan He and @gagliardi8 are two new EICs of ACS journals! New editors in chief named for four American Chemical Society journals - American Chemical Society
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Nobel Prize-winning biochemist Jack Szostak will join the #UChicago faculty as a University Professor in the Department of Chemistry and the College. https://t.co/oU8mgoS0Of
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Postdoctoral positions available at the Tay Lab ( https://t.co/YEvrTxotKK). We want to recruit scientists to develop single-cell spatially resolved proteomic and transcriptomic technologies. The positions are funded by the Paul G. Allen Foundation @AllenInstitute
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Congratulations to @UChiChemistry Prof. Dmitri Talapin, co-founder of NanoPattern Technologies, and Asst. Prof Raymond Moellering, founder of ReAx Biotechnologies. Both start-ups were selected to receive $150,000 to commercialize research. https://t.co/YjmBC7l1lw
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The Department of Chemistry is proud to announce that four of our academics have been named on the annual Highly Cited Researchers 2020 list from @clarivate. Congratulations to Chuan He, @wenbinlin_uc, Jiwoong Park, and Luping Yu for the recognition of their impactful work.
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UofC is searching for a Director of our proteomics technology center. This senior staff position will help build and lead this platform alongside other growing efforts in metabolomics, genomics and chemical biology. Please forward/retweet.
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