Kannouche Lab
@KannoucheLab
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Our lab at Gustave Roussy Institute studies DNA replication and error-prone mechanisms of repair leading to cancers and drug resistance.
Villejuif - Grand Paris France
Joined November 2022
Merci au Canard Enchaîné de se soucier de la crédibilité scientifique du @HCERES_, l'organisme qui évalue l'enseignement Supérieur et la recherche. @suprecherche Que son président soit prêtre ou psychanalyste, ce serait vraiment une mauvaise farce.
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📢Check out this Article NOW ONLINE! @NatureCancer '#Transcription and #DNAreplication collisions lead to large tandem duplications and expose targetable #therapeutic vulnerabilities in #cancer' ✏️By Jonathan Chou, Lixing Yang and colleagues 📎 https://t.co/MyQVvgPWsq
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Online Now: STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment https://t.co/aTKV2IFISN
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Excited that our work on transcription-coupled DNA repair is now published @CellCellPress! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples stalled Pol II to TFIIH. 🧬🐸 ➡️ https://t.co/0SDr81nzhu
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I’m thrilled to share this preprint, in which we @BaubecLab engineer DNA damage probes to track DNA damage dynamics by live cell imaging and to probe the DNA damage-associated proteome via proximity ligation:
biorxiv.org
DNA damage is a constant threat to genome integrity and function. Diminished capacity for DNA repair is linked to many human diseases, therefore understanding the molecular pathways responding to DNA...
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We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: https://t.co/ysMXHk7ApK
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We are recruiting for a Research Assistant (Computing) (Fixed Term) @Cambridge_Uni
https://t.co/MVZUHDzQnT Please share
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Les contours des sections du CoNRS vont changer https://t.co/nZYK7uXxj5 Création de deux sections supplémentaires, modification des périmètres de plusieurs autres sections, modification de l’intitulé de huit sections et nouvelle numérotation de toutes les sections. @CNRS
cnrs.fr
Début septembre 2025, le mandat des sections du Comité national de la recherche scientifique arrive à échéance.
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We have an exciting PhD project available within the @CRUKCOLcentre at @QMBCI to investigate novel mechanisms of sensitization to PARP inhibitors. Enthusiasts in genome stability and cancer therapeutics get in touch and apply ! please RT https://t.co/642QfYlhty
colcc.ac.uk
Investigating the role of DNA Polymerase Epsilon in sensitization to PARP inhibitors Primary supervisor: Roberto Bellelli, Queen Mary University of London Secondary supervisor: David Michod, UCL...
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Thrilled to share our new work @biorxivpreprint: https://t.co/6unXV2pn2C Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live cells. We reveal genome chromatin is essentially replicated from regions with greater nucleosome motions. 1/2
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Our team in Orléans (France) is looking for a new postdoc, to work closely with a research associate, Ibtissam Talhaoui, on a project focused on potential SUMO E3 ligases targeting the nucleosome. The details here:
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I am super excited to show our work, now published in NAR @NAR_Open, on the structural function of SLF1 at the stalled replication fork. @AstburyCentre @ScienceLeeds
academic.oup.com
Abstract. DNA damage that obstructs the replication machinery poses a significant threat to genome stability. Replication-coupled repair mechanisms safegua
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À l'occasion de la journée internationale de la bibliodiversité 📚 et 5 ans après la publication de la feuille de route du @CNRS pour la #ScienceOuverte, @AlainSchuhl dresse un point d’étape sur l’ouverture des publications scientifiques. https://t.co/nzr9ZkkGic
cnrs.fr
Le CNRS a publié sa
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Looking for PhD students/postdocs for my newly opened lab at the Institute of Human Biology of #Roche in Basel. We work on human lung, liver and gut #organoids. Send email + CV + motivation letter to hans.clevers@roche.com with header #IHB
https://t.co/5Ki03fy4NH
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Ensuring that clinics in low- and middle-income countries are well-stocked with high-quality antibiotics could help physicians to treat millions of people each year and slow the spread of drug resistance, says Ramanan Laxminarayan
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By 2050, around 2 million people — the majority aged over 70 — could die from drug-resistant infections each year
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[APPEL AUX SCIENTIFIQUES FRANCOPHONES] RT pour l'amour des sciences 🙏 Tous les matins sur @franceculture, je fais parler un.e https://t.co/PSRglJaQp7 d'une étude qui vient de paraître dans son domaine, souvent une dont il est co-auteur.trice mais pas toujours.
Et hop, c'est la rentrée des sciences ! 🦕🧪🦠🦟🐒 "Avec Sciences" redémarre lundi, en direct sur @franceculture à 6h52 (oui c'est tôt) Chaque jour, je décortique avec l'aide d'un.e scientifique, une étude qui vient de paraître 🧑🔬
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📢Open call: #IRBBarcelona International PhD #Fellowships Programme 2024! 👉Up to 5⃣ #PhD positions for promising young scientists from around the world eager to pursue a doctoral degree in #biomedicine. Apply by September 22! ➡️ https://t.co/iKprZCcryB
@CienciaGob
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We are looking for posdocs to join our research team and work on genomic instability, cGAS-STING signaling and TREX1 exonuclease. If you have or will have a PhD in cancer, cellular or molecular biology and want to apply to postdoctoral fellowship contact us @ircaninstitute
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