ConstantinouLab
@ConstantinouL
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Molecular Bases of Human Diseases
Montpellier, France
Joined November 2019
Our latest work "TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer" led by Laura Morano, is now out in @eLife! Huge thanks to our collaborators at @IGH_MTP & @ircm_mtl. And a special thought goes to Angelos. đ
elifesciences.org
Pharmacological disruption of TopBP1 condensation impairs ATR signaling, promotes DNA damage and apoptosis, and enhances the efficacy of FOLFIRI chemotherapy in colorectal cancer.
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Dear Colleagues, We are extending our early bird registration deadline to December 17th as there have been some issues both with the Carte Achat service as well as with the website. All have now been sorted. https://t.co/ysMXHk7ApK
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We wish to draw your attention to the fact that the meeting is limited to a total of 150 participants including our 20 invited speakers. The deadline for Early Bird registration is December 1st 2024. If you have any questions, you can send an email at tribute2angelos@gmail.com
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We are pleased to inform you that the meeting âFrom Genome Instability to Cancer: A tribute to Angelos Constantinouâ that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: https://t.co/ysMXHk7ApK
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Thrilled to share our latest preprint, led by our fantastic PhD student Laura Morano, proposing Topbp1 condensates as a potential therapeutic target for advanced colorectal cancer. Great collaboration with Celine Gongora & Nathalie Bonnefoy's teams! #IGH
https://t.co/Dfs3XK66xw
biorxiv.org
In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein,...
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Congratulations to our former PhD student @EmileElGhoul for the prestigious award "Les grandes avancĂ©es Françaises en Biologie 2024" by the AcadĂ©mie des sciences ! Well deserved đ @IGH_MTP
𧔠1/9 Aujourd'hui, dans la grande salle des sĂ©ances de l'@InstitutFrance, l'AcadĂ©mie des sciences remet les prix « Les grandes avancĂ©es françaises en biologie » Ă six jeunes scientifiques pour leurs dĂ©couvertes majeures. DĂ©couvrez leurs travaux primĂ©s đ
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I want to express my gratitude to Laura Morano and Tom Egger for their exceptional dedication and the remarkable work they have accomplished despite the challenging circumstances faced by our lab.
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Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates: Cell Reports
cell.com
Egger et al. implement their previously proposed ATR/Chk1 activation model by dissociating the functions of ATR and Chk1. Using reverse genetics and optogenetics, they show that Chk1 is phosphoryla...
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We are pleased to announce the publication of our latest paper. Although this achievement comes with mixed emotions, we dedicate this work to the memory of our esteemed team leader Angelos Constantinou whose vision continue to inspire us. @IGH_MTP
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The Department of Immunobiology mourns the death of our former colleague Angelos Constantinou on January 19. Angelos worked with us from 2004 to 2010, and we remember him as a highly committed researcher and teacher. We send his family and friends our deepest condolences.
It is with deep sorrow that we share the news of Angelos Constantinou's passing today. Angelos was not only a remarkable scientist but also a cherished colleague and friend. Our heartfelt condolences go out to his family during this difficult time. He will be profoundly missed.
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The IGH @CNRS_OccitaniE regrets to announce the death of Angelos Constantinou, one of its most brilliant team leaders, who joined us nearly 14 years ago. We are all deeply saddened by this terrible loss and our thoughts are with his family and friends. He will be sorely missed.
It is with deep sorrow that we share the news of Angelos Constantinou's passing today. Angelos was not only a remarkable scientist but also a cherished colleague and friend. Our heartfelt condolences go out to his family during this difficult time. He will be profoundly missed.
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Today I lost not only my mentor but also a close friend. His impact on my life and work is immeasurable. Grateful for the time and the wisdom we shared. Rest in peace, Angelos. đïž
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It is with deep sorrow that we share the news of Angelos Constantinou's passing today. Angelos was not only a remarkable scientist but also a cherished colleague and friend. Our heartfelt condolences go out to his family during this difficult time. He will be profoundly missed.
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I am happy to share that our review is out in the special Genome Maintenance issue of DNA repair @repair_dna, edited by Penny Jeggo. Thank you and congratulations to shrena and kamila @schirmeisen_K for this collaborative work. https://t.co/v9LmXjStMD
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The next DINGO meeting (Dynamic of Genetic Instability and oncogenesis) will take place at Institut Jacques Monod the 14-15 November 2023. Great list of speakers + short talks from selected abstracts. @PaseroLab, @KannoucheLab, @PalancadeLab, @Bernard_S_Lopez, @VincentGELI1.
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Congratulations on your excellent thesis defense Emile! @EmileElGhoul, we are all proud of you. And many thanks to Anne-Marie Martinez, Gaelle Legube @LabLegube, Simon Alberti @Simon Alberti1, Matthias Altmeyer @altmeyerlab and all the friends for making this event unforgettable.
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We are very excited today to share our work in @Nature defining the structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2) tumour suppressor complex https://t.co/AJXPsWATfC. Thread (1/10)
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Dear all, our review on the functions of condensates formed in response to DNA damage is available in open https://t.co/TbmYXPE00T. Condensates are the subject of polarized discussions. We strived to propose a path through the nuclear landscape. Hope you will find it useful.
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Thrilled to share this fantastic collaborative study: A multi-scale map of protein assemblies in the DNA damage response https://t.co/deiZsJIidH
@CancerCellMap @KroganLab @MinkyuKim20
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