Jonathan Bohlen
@Jonathan_Bohlen
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I have decided to withdraw myself to posting research papers only on this website. Unfortunately, it has become neither enjoyable nor productive to be here. If you want, come and hang out, for example on bluesky:
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RT @BoissonDupuis: 1/ We are delighted to share our work published in @SciImmunolgyidentifying the role of LY9 in CD4+ T cell IFN-γ immunit….
science.org
Impaired CD4+ T cell–dependent IFN-γ immunity in humans with LY9 deficiency underlies tuberculosis.
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RT @alqurefa: 1/ I am excited to share our new paper from @casanova_lab published today in @JExpMed about humans with autosomal dominant IF….
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RT @ShenYingZhang1: We reported recessive DBR1 deficiency underlying brainstem viral encephalitis in humans in 2018 (.
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Landmark paper from my colleague and friend Masato @casanova_lab ! A must read!!.
1/ We report @ImmunityCP that the PD-1:PD-L1 axis promotes the development of B-cell memory and antibody responses in mice and humans. To our surprise, the pro-B-cell effect of PD-1 and PD-L1 is, at least partially, mediated in a B-cell-intrinsic manner.
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RT @humanimmunenews: Autoinflammation in patients with leukocytic CBL loss of heterozygosity is caused by constitutive ERK-mediated #monocy….
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RT @jclinicalinvest: Why do some patients with a CBL genotype develop autoinflammatory disease? @Jonathan_Bohlen @….
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Wow, what an amazing experience this year's @ESIDsociety meeting was! A community driven by scientific curiosity and the motivation to help patients. It was a huge pleasure to present my work in front of this audience!
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RT @JRosain: A beautiful investigation into how germline heterozygous CBL variants lead to autoinflammation when accompanied by somatic los….
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RT @ShenYingZhang1: Germline + somatic CBL mutations in leukocytes result in autoinflammation. Great work led by @Jonathan_Bohlen !.
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RT @ALNeehus: Congrats to my friend @Jonathan_Bohlen for another amazing story published! 🎉 Very happy to have had the chance to work with….
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RT @casanova_lab: Excellent thread by @Jonathan_Bohlen about germline + somatic deficiency of CBL in leukocytes resulting in autoinflammati….
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RT @LabWaggoner: Autoinflammation in patients with leukocytic CBL loss of heterozygosity is caused by constitutive ERK-mediated monocyte ac….
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@casanova_lab @BustamanteJaci1 @MasatoOgishi @AxelCederholm @FlocCorentin @CarlosArangoFr1 @MarineMichelet @Saettini_F @filippoconsonni @francescaconti @BorisBessot @JRosain @ALNeehus @anne_puel @stutangye @ShenYingZhang1 @BeziatV, Chantal Lagresle-Peyrou, Emmanuelle Six, @marlene_pasquet , @laiaalsina_, Alessandro Aiuti, @zhangpeng1202, @crow_lab, Nils landegren,Riccardo Masetti, Danny T. Huang, @casanova_lab and @BustamanteJaci1.
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@casanova_lab @BustamanteJaci1 @MasatoOgishi @AxelCederholm @FlocCorentin @CarlosArangoFr1 @MarineMichelet @Saettini_F @filippoconsonni @francescaconti @BorisBessot @JRosain @ALNeehus Lucia Erazo-Borrás, Hailun Li, Zarah Janda, En-Jui Cho, Edoardo Muratore, Camille Soudée, Candice Lainé, Eric Delabesse, Claire Goulvestre, Cindy S Ma, @anne_puel @stutangye, Isabelle André,.Christine Bole-Feysot, Laurent Abel, Miriam Erlacher, @ShenYingZhang1.
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@casanova_lab @BustamanteJaci1 @MasatoOgishi @AxelCederholm @FlocCorentin @CarlosArangoFr1 @MarineMichelet @Saettini_F Albert Catala, Eleonora Gambineri, Marinella Veltroni. Yurena Aguilar de la Red, Gillian I. Rice, @filippoconsonni, Laureline Berteloot, Laetitia Largeaud, @francescaconti, Cécile Roullion, Cécile Masson, @BorisBessot ,Yoann Seeleuthner, Tom Le Voyer, Darawan Rinchai, @JRosain.
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@casanova_lab @BustamanteJaci1 Massive thanks also to all the contributors and authors: @MasatoOgishi, Seyed Ahmed, @AxelCederholm, Lori Buetow, Steicy Sobrino, @FlocCorentin, @CarlosArangoFr1, Luis Seabra, @MarineMichelet, Federica Barzaghi, Davide Leardini, @Saettini_F, Francesca Vendemini, Francesco Bacelli.
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Huge thanks to all the contributors, including my excellent mentees and now PhD students Taja Vatovec and Ivan Bagaric, who contributed massively to this project. I also thank my mentors @casanova_lab and @BustamanteJaci1 for their relentless support. 8/8+.
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Deep gratitude and admiration to the patients and their families for selflessly contributing to and supporting our research. Without them, none of this would be possible. We hope this work contributes to the understanding of this disease and eventually to the treatment. 7/8.
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Finally, we found that a large number of people in the general population is heterozygous for these deleterious CBL variants (e.g. 8000 people in Germany). And using the UKBB we found significant associations of inflammatory and myelodysplastic phenotypes with this genotype. 6/8
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