Jonas Van lent
@JonasVanlent
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Postdoctoral researcher. Interested in iPSC-derived PNS neuronal models
Joined June 2021
1/ I am happy to share our latest publication in Nature Neuro https://t.co/QCdfr2RRf8. We present the first subcellular proteomic atlas of the myelin–axon interface in human and mouse brain, revealing extensive Alzheimer‑related abnormalities.
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🚨 PhD opportunity alert! Exciting opportunity to join our lab in Bellinzona ⛰️🇨🇭! We're looking for a motivated PhD student to work on an innovative project related to pluripotent stem cells and the peripheral nervous system 🧬 Check it out below 👇 https://t.co/8RbRF9fwTm
ior.usi.ch
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Great read on how sensory neurons help regulate inflammation and defense @ImmunityCP @CellPressNews
Online now: Role of specialized sensory neuron subtypes in modulating peripheral immune responses
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Our new review is out in @NatureNeuro ! 🧠 We dive into the transcriptional diversity of microglia across development, disease, regions, and sexes—highlighting emerging tools + a new resource for cell state annotation. @MancusoRenzo @VIBLifeSciences
I am so excited to share our review on microglial heterogeneity @NatureNeuro! It was a fantastic effort by the lab, led by @C9Laura72 and Alma Mohebiany. We provide a critical view on the plethora of microglial cell states in health and disease.
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Macrophages protect against sensory axon loss in peripheral neuropathy @Nature
https://t.co/sLQs0iZ9CY
nature.com
Nature - A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.
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📣 #OncogenicCompetence what are the factors regulating it? Have a look at our opinion article in @trendscancer led by our 🌟 postdoc @lisapavinato 🌟
❓How does a cell become malignant? 🌟Several tightly regulated factors are needed to lead the cell toward a state of ‘oncogenic competence’. 🔖In this Opinion, we highlight the most updated findings about the mechanisms behind oncogenic competence. ➡️ https://t.co/qPlacIth9U
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My first-author paper is out today @NatureComms ! We investigated how oligodendrocytes produce myelin. Using volume EM, we characterized oligodendroglial ER (magenta) in developing myelin and explored nonvesicular lipid transport involved. #lipidtime
https://t.co/COW6ZjIQk7 (1/n)
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Come work with us on pioneering projects in stem cell technology and cancer neuroscience! Amazing collegues, beautiful surroundings - join us! 🌟✨👇
📢Join our lab and the Bioinformatics Core Unit led by @CascioneLuciano! If you're excited about projects at the intersection of stem cell tech, cancer neuroscience, and genomics, we'd love to have you on our dynamic and fun team. 🌱✨ #Bioinformatician #stemcells #CancerResearch
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📢 Big congratulations to our stellar postdoc🌟🚀, Dr. @JonasVanlent , on securing this fantastic grant🎉🎉🎉! Thrilled to see all the groundbreaking science and discoveries that await!
Dr. Jonas Van Lent from Prof. Arianna Baggiolini's Stem Cells & Cancer Lab has secured the prestigious SNSF grant! His research on pain, proprioception, and balance using human #stemcells could pave the way for new therapies. Exciting times ahead 🚀 #SNSFSpark #stemcells #news
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Dr. Jonas Van Lent from Prof. Arianna Baggiolini's Stem Cells & Cancer Lab has secured the prestigious SNSF grant! His research on pain, proprioception, and balance using human #stemcells could pave the way for new therapies. Exciting times ahead 🚀 #SNSFSpark #stemcells #news
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1/12 Excited to share our new paper, “Leveraging Deep Single-Soma RNA Sequencing to Explore the Neural Basis of Human Somatosensation,” now out in @NatureNeuro! 🎉
nature.com
Nature Neuroscience - Dorsal root ganglia (DRGs) contain a plethora of neuron types. The authors show that the existence of human-specific DRG neuronal types and microneurography recordings reveal...
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Delighted to share our paper on the influence of the #NodeOfRanvier on in vivo #axonaltransport of #mitochondria and #signallingendosomes @iScience_CP @SchiavoMNPlab @J_N_Slayer @samuscientist. A project that started in 2018 but has finally seen the light of day!
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Check out the latest @VolumeEM1 case study from @giulia_casal @EM__Ian @JemimaBurden and Alison Lloyd @LMCB_UCL. They explain how they used array-tomography-SEM to reveal the cellular composition of the Blood Nerve Barrier. https://t.co/Udqcn88WGq
focalplane.biologists.com
vEM reveals the cellular composition of the Blood Nerve Barrier - Volume EM
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🧬Our latest research is now online on @medrxivpreprint!🧬 We show that heterozygous variants in SPTAN1 cause a novel type of distal myopathy. While α-2-spectrin is well-known for its role in the axonal membrane periodic system, its function in muscle fibers is less explored🤔
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Officially out! 🎊🍾🎉
Online now: Protocol for generating human cortical organoids enriched in outer radial glia by guided differentiation https://t.co/POLmQ6Jo6S
#protocol #starprotocols #cellpress
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Super cool! Divergent sensory pathways of sneezing and coughing: Cell
cell.com
Sneezing and coughing are frequently associated with allergies and respiratory viral infections. This study reveals that sneezing and coughing are initiated by discrete sensory receptors and transm...
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I’m happy to share that our new @STARProtocols paper detailing the steps to generate #hPSCs derived 1) LIF-treated cortical #organoids 2) LIF secreting #pericytes 3) Cortico-pericyte #assembloids is finally out! 🎉🎉🎉 Check it out at: https://t.co/tiEJWI6cO0
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Discovery of human-specifc spinal motor neuron progenitors that remain cycling longer than classical progenitors, yielding ~5 times more neurons https://t.co/RpiBUv5aPg
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I am so thrilled that my work from the Feltri lab is now published in @GLIA_Journal. Trying to understand why and how #Schwanncell prohibitin 2 (PHB2) is critical for #radialsorting and #myelination in the developing peripheral nerve. ---> https://t.co/AGaBEEe12J
onlinelibrary.wiley.com
Loss of Schwann cell (SC) PHB2 causes severe radial sorting and myelination defects. PHB2-null SCs exhibit poor proliferation and transcription factor dysregulation. PHB2 may play a role in formati...
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🚨 New paper alert from @martenssascha!🚨 We explore how transmembrane cargo receptors initiate selective autophagy. Through biochemical reconstitutions, we discover a new autophagosome biogenesis pathway with implications for therapeutic interventions. https://t.co/tud1Iq4RPg
biorxiv.org
Selective autophagy is a lysosomal degradation pathway that is critical for maintaining cellular homeostasis by disposing of harmful cellular material. While the mechanisms by which soluble cargo...
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