Jenelle Wallace
@JenelleLWallace
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Postdoc @UCSF Pollen lab @brainevodevo. Evolution of brain development and plasticity. Rock climber, kayaker, skier. She/her.
San Francisco, CA
Joined June 2014
Privileged to write this preview with @brainevodevo - congrats to @CcileCharrier, @blibep, @VanderhaeghenP2, @fpolleux, and lab members for the beautiful work!.
@JenelleLWallace led a preview of two outstanding papers from @CcileCharrier , @blibep , @VanderhaeghenP2 , @fpolleux et al that connect regulation of the tempo of synaptogenesis by the human-specific gene SRGAP2C to ASD-linked genes: .
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RT @NatRevNeurosci: Human neuronal maturation comes of age: cellular mechanisms and species differences — a Review by Jenelle L. Wallace &….
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Huge thanks to everyone in @Lab_Pollen who contributed ideas and discussion and especially to @brainevodevo, the best coauthor anyone could ask for, and a huge support in putting this together during an incredibly difficult time in my personal life.
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In parallel, we cover state-of-the-art methods for producing, growing, and maturing human neurons and assessing their maturation. Also, I would be overjoyed if anyone looks at the extensive supplementary tables I put together on this topic :)
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and we propose a (hopefully fun and memorable!) framework of testable hypotheses for future studies of maturation mechanisms.
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mechanisms that may contribute to species differences,
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We discuss cell-intrinsic and cell-extrinsic mechanisms and their interactions,
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I'm thrilled to announce that the review I wrote with @brainevodevo is now online @NatRevNeurosci: We cover mechanisms of prolonged human neuronal maturation, integrating lessons from model organisms with studies on species differences.
nature.com
Nature Reviews Neuroscience - Human cortical neurons undergo a protracted period of postmitotic maturation compared with those of other species. Wallace and Pollen review the cell-intrinsic and...
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Taking my love of science to a whole new level today by signing up to get injected with a radioactive isotope and then sit still for an hour in a PET scanner.
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RT @VirusesImmunity: An excellent article by @patrickc highlighting the barriers for academics like myself to develop universal and nasal C….
slowboring.com
Bureaucratic and logistical roadblocks, not the science, stand in our way
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Congrats @irenechen_png! So grateful to all the researchers working to understand and beat this virus (#CovidIsNotOver).
Delighted to officially share my thesis work on how and why #SARSCoV2 Envelope interacts with cellular transcription factor, BRD4! @CellReports .@J_Longbotham @TheOttLab @FujimoriLabUCSF @GladstoneInst @Gladstone_GO @UCSF.
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RT @Bob_Wachter: In today's @washingtonpost, I describe why it's prudent to remain careful despite the fall in hospitalizations & deaths in….
washingtonpost.com
The potential for long-term symptoms complicates “back to normal” arguments.
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RT @ariannahuff: So, to sum up the Supreme Court’s week: life begins at conception and ends in a mass shooting.
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RT @GavinNewsom: Abortion is legal in California. It will remain that way. I just signed a bill that makes our state a safe haven for wom….
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Important thread about #LongCovid .While we may now have the tools to prevent many (though not all!) covid deaths and hospitalizations, it is less clear that we understand anything about how to prevent or treat long-term symptoms, which are not as uncommon in vaxed as we hoped.
Covid (@UCSF) Chronicles, Day 848.It’s been a few weeks since my last update – the flow of Covid news & research has slowed a bit. But there’s still plenty of questions that come up, so in this🧵I’ll answer a few that I get asked commonly, including how my wife is doing. (1/25).
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Saw some of this work presented at SFN awhile ago, super excited to read the whole story! Congrats @Nathan_the_Gray!.
Happy to announce the release of my work in the Komiyama lab, in which we try to understand more about the function of new synapses that form during learning. We all have an intuition about how new synapses change our brain and behavior (1/n).
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Thankful to all the public figures here who have opened up about their long covid struggles, it makes the rest of us feel a little less alone.
There's a common myth being passed around that longCOVID is rare, that it only affects medically infirm people, that it can't happen to me. Here's a short thread on the famous people that are dealing with #longCOVID 1/
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Cool study using a combo of lineage tracing and Patch-seq to learn about those fancy-looking human astrocytes!.
Pleased to share the latest study by @InBay01 @crcadwell @sohallab @mattgkeefe @DavidSh90791209 and Kevin Donohue revealing complex developmental origins of human astrocytes
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Seems to be anecdotally true among friends and colleagues, wonder about time from booster vs virus itself.
"Contrary to the perception that recent variants have become successively milder, Omicron BA.2 was associated with reporting more symptoms, with greater disruption to daily activities [than BA.1]" .BA.2 vs BA.1 Figure 👇.
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