Jed Barash
@JedBarash
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Neurologist / Researcher, helped catch "The Memory Thief" (opioid-associated amnestic syndrome)/ Enthusiast of a good case report and the New York Yankees
Boston, MA
Joined July 2021
📣 New article alert! 📣. Great to work with Feng Sha @AndrewKofke et al exploring assoc betw regular opioid exposure, MRI brain volumetrics, and dementia outcomes 🧠. @alzdemjournals 🔓. 1/brief 🧵.
alz-journals.onlinelibrary.wiley.com
INTRODUCTION We investigated the association between regular opioid use and incident dementia, neuroimaging outcomes, and cognitive measures. METHODS Cox regression was used to assess the associat...
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Really nice educational video from @YaleRadiology on a case of opioid-associated amnestic syndrome - worth a view! 👀 . @francisdeng @AndrewKofke @josh_emncc @AANmember .
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RT @DocNavarrow: ✅CHANTER syndrome (Cerebellar, Hippocampal, and Basal Nuclei Transient Edema with Restricted diffusion). 🐉Seen in acute i….
neurology.org
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RT @DocNavarrow: 🙄44-year-old man with history of alcohol use disorder is found unresponsive. Toxicology positive for cocaine and fentanyl.….
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Important study!.
Excited to share my new study with the @VETSATwinStudy team (@Jeremyelman @PanizzonLab) published in #JINS showing that moderate-to-severe chronic pain and opioid use are independently related to risk of mild cognitive impairment. @UCSanDiego
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RT @francisdeng: Opioid-induced neurotoxicity has a spectrum of neuroradiologic manifestations. Are you familiar with these?. @FrankGaillar….
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Thanks for amplifying our work!. One clarification: opioid use and non-opioid analgesic use were each compared to non-analgesic use. Opioid use showed an increased risk of dementia, as noted, whereas non-opioid analgesic use did not.
Regular opioid use may increase dementia risk. The researchers found that regular opioid use was associated with a 20% higher risk of all-cause dementia compared with taking analgesics. Participants who regularly used strong opioids had a over 70% increased risk of dementia, and
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They conclude:. “…chronic pain was not strongly linked to episodic memory decline or amnestic MCI. Interestingly, opioid use… doubled the risk of amnestic MCI, suggesting distinct cognitive consequences for chronic pain versus opioid use.”.
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BUT:. “…a history of opioid use was related to an increased likelihood of progression to amnestic MCI (HR = 1.99, 95%CI: 1.05, 3.77, p = .036). Among with a history of opioid use, 16.9% developed amnestic MCI compared to 7.7% not taking an opioid medication.”. 3/.
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“A history of chronic pain intensity or chronic pain interference of any severity was not related to greater risk of incident amnestic MCI (all p-values were > .05).”. 2/.
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🚨 Important work by @TylerBellPhD et al just out in J Int Neuropsychol Soc. 1/🧵.
cambridge.org
History of chronic pain and opioid use is associated with cognitive decline and mild cognitive impairment
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RT @LEAD_Coalition: Regular Use of Strong #Opioids May Lead to Increased #Dementia Risk by @NeuroAdvisor. #Alzheime….
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Opioid associated amnestic syndrome and CHANTER in differential.
💊 Confusion, hyperalgesia, myoclonus? Think Opioid-Induced Neurotoxicity (OIN). A new @CJEMonline Just the Facts reviews how to recognize and manage this under-recognized cause of delirium in the ED. Hydrate, rotate, reduce. 📄 Read more: ✍️ Fischer L.
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RT @CJEMonline: 💊 Confusion, hyperalgesia, myoclonus? Think Opioid-Induced Neurotoxicity (OIN). A new @CJEMonline Just the Facts reviews h….
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RT @SleepWakeAdv: The regular use of #opioids, particularly strong opioids, is associated with an increased risk for #dementia among patien….
sleepwakeadvisor.com
Researchers evaluated the association between regular use of opioids and incident dementia risk among patients with chronic noncancer pain.
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RIP Dave Parker. The Cobra passed away after a long battle w Parkinson’s, just a month short of his Hall of Fame induction. Always known for his bat, but this throw shows the all-around talent he was. @MichaelOkun.
If you’ve never seen the National League dugout’s reaction to Dave Parker’s phenomenal throw from right field to Gary Carter in the 1979 All-Star Game, it’s even better than you’d imagine.
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