Jed Barash
@JedBarash
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Neurologist / Researcher, helped catch "The Memory Thief" (opioid-associated amnestic syndrome)/ Enthusiast of a good case report and the New York Yankees
Boston, MA
Joined July 2021
📣 New article alert! 📣 Great to work with Feng Sha @AndrewKofke et al exploring assoc betw regular opioid exposure, MRI brain volumetrics, and dementia outcomes 🧠 @alzdemjournals 🔓 1/brief 🧵 https://t.co/DFP8MNbS6O
alz-journals.onlinelibrary.wiley.com
INTRODUCTION We investigated the association between regular opioid use and incident dementia, neuroimaging outcomes, and cognitive measures. METHODS Cox regression was used to assess the associat...
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Would like to see a similar MCI trial for naltrexone, which has a clearer potential mechanism(s) including CNS penetrance, longer clinical experience, is more scalable based on cost
Forecasting $NVO's EVOKE/EVOKE+ semaglutide in early-stage Alzheimer Disease trial results https://t.co/fzeuc406nD Open to discussion, please share thoughts and comments.
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Interesting story on complications associated with surviving opioid overdose — including mention of hippocampal injury — by @erikafry in @guardian
https://t.co/YuNuT5aZz1
theguardian.com
After overdoses left them with brain injuries and lasting complications, Americans are struggling to get proper care. Experts call it another epidemic
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🧠 Fentanyl misuse can cause CHANTER syndrome: Cerebellar, hippocampal and basal nuclei transient oedema with restricted diffusion. There’s a characteristic MRI pattern: restricted diffusion in the basal ganglia and hippocampi, with cerebellar oedema and haemorrhage. 📖 Open
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Credit to @PracticalNeuro for raising awareness
🧠 Fentanyl misuse can cause CHANTER syndrome: Cerebellar, hippocampal and basal nuclei transient oedema with restricted diffusion. There’s a characteristic MRI pattern: restricted diffusion in the basal ganglia and hippocampi, with cerebellar oedema and haemorrhage. 📖 Open
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Was honored to be at the naming of Mass DPH campus at Jamaica Plain after Dr Al DeMaria, a living legend in public health and huge influence on my own path
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More evidence for opioid antagonism as a potential therapeutic intervention in Alzheimer’s spectrum disorders, this time at delta receptors Naltrexone is a non selective opioid antagonist w established track record and worth a pilot trial https://t.co/OX3UHUmAUP
pubs.acs.org
Alzheimer’s Disease is a growing health concern, with no available disease-modifying treatments. A previous report suggested that a Delta Opioid Receptor (DOR) antagonist could prevent Alzheimer’s-...
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Studied food deserts in fellowship, interesting to see this study extending food insecurity to cognitive outcomes 🥗 ➡️ 🧠 @JAMANetworkOpen
https://t.co/XOlOp1gZAb
jamanetwork.com
This cohort study examines the associations between food insecurity and the risks of dementia, cognitive impairment with no dementia, and cognitive impairment with dementia among US older adults.
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Characteristic imaging patterns in toxic and acquired metabolic disorders of the central nervous system (schematic) 🧠🤮💊🫗
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Biggest win of the year for the @yankees That was either the peak or they’re onto something
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Losing teams can’t cash in with a bases-loaded hit for two innings in a row, then immediately respond by blowing the lead in sloppy fashion — the 2025 NY Yankees
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Really nice educational video from @YaleRadiology on a case of opioid-associated amnestic syndrome - worth a view! 👀 @francisdeng @AndrewKofke @josh_emncc @AANmember
https://t.co/YeYNA7ygfz
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✅CHANTER syndrome (Cerebellar, Hippocampal, and Basal Nuclei Transient Edema with Restricted diffusion). 🐉Seen in acute intoxication, often with opioids or cocaine. 💡Cortical and white matter sparing helps distinguish it from anoxic injury. https://t.co/klJCrM1l4V
neurology.org
🙄44-year-old man with history of alcohol use disorder is found unresponsive. Toxicology positive for cocaine and fentanyl. 🏥🤔What syndrome explains the clinical context and radiologic pattern?
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🙄44-year-old man with history of alcohol use disorder is found unresponsive. Toxicology positive for cocaine and fentanyl. 🏥🤔What syndrome explains the clinical context and radiologic pattern?
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Important study!
Excited to share my new study with the @VETSATwinStudy team (@Jeremyelman @PanizzonLab) published in #JINS showing that moderate-to-severe chronic pain and opioid use are independently related to risk of mild cognitive impairment. https://t.co/rYsb0BsLu7
@UCSanDiego
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Opioid-induced neurotoxicity has a spectrum of neuroradiologic manifestations. Are you familiar with these? @FrankGaillard at @Radiopaedia Day 1 (supraclavicular radiology)
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Thanks for amplifying our work! One clarification: opioid use and non-opioid analgesic use were each compared to non-analgesic use. Opioid use showed an increased risk of dementia, as noted, whereas non-opioid analgesic use did not.
Regular opioid use may increase dementia risk The researchers found that regular opioid use was associated with a 20% higher risk of all-cause dementia compared with taking analgesics. Participants who regularly used strong opioids had a over 70% increased risk of dementia, and
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They conclude: “…chronic pain was not strongly linked to episodic memory decline or amnestic MCI. Interestingly, opioid use… doubled the risk of amnestic MCI, suggesting distinct cognitive consequences for chronic pain versus opioid use.”
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