Adith Arun
@aditharun_
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md candidate @yalemed, writing at https://t.co/gffDMMDkZR, prev @delfidiagnostic @ibmresearch and math @johnshopkins. Views my own.
United States
Joined September 2018
Some takeaways from my conversation with Barry Borluag on his recent paper in @JACCJournals - Ventricular-secondary tricuspud regurigitation (V-STR) patients (no right heart cath needed for V-STR/Atrial-STR distinction) identified on echo are a population that need to be
In #JACC’s first Behind the Science, @aditharun_ chats with Dr. Barry A. Borlaug on TR in #HFpEF. VSTR is the most common type, even early in disease (≈26% vs ≈8% ASTR). https://t.co/r60GqqNPpl
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Article published premarket Dec 11, and 18% slide since Correlation or causation. Unclear.
In this week's Biotech Scorecard newsletter: $WVE Wave’s ‘gym bro’ obesity drug is story over substance https://t.co/XATxYYS3zB
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My top 10 books of 2025 - Silence in the age of noise - Random acts of medicine (@AnupamBJena @ChrisWorsham) - The inner game of tennis - The lives of a cell - On writing (@StephenKing) - The idea factory - Love and math - Hardball - Titan - From third world to first Not a
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I have been grinding my teeth in my sleep. Started ~6 months ago. Any suggestions on how to resolve it would be much appreciated, even armchair opinions. Not interested in night guards at the moment, it made it worse. I’m willing to change my routines/etc. too. For reference,
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The actual values in this example are wrong but the premise holds and is doable with current AI.
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This + each number links to the exact line of the financial report from which the number was pulled UI has got to look nice. I want it to still be a spreadsheet but if I hover or something it should take me to the exact UBER SEC filing and highlight the number.
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Looking back on $RZLT: 1. Placing stock in open label no placebo trial results 2. Overweighting interim analysis recommendation 3. Valuation as a tool for slowing you down 1. Placing stock in open label no placebo trial results Phase 2b RIZE study results (n = 23) showed 74%
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"market dynamics know nothing of objectivity anymore. They have become a rigged, bloated, algorithm-warped humiliation ritual masquerading as a market — a parody of what price discovery used to be" "What exists now is something fundamentally different, an environment where being
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Chat guesses that the rate of private credit borrowers unable to cover interest costs is up from 5% in 2021. Default risk rising and growth may slow? May accelerate AI usage in attempt offset costs if true someone who knows credit please chime in
15% of private credit borrowers aren’t generating enough operating profit to cover interest costs, per Goldman Sachs, $GS.
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@zhaoweiasu @medstudentinvst $rzlt I had a tiny position (reasons outlined in quoted post) but I did like the science. The science turned out not to lead to clinical results. And that’s something to study. Position sizing very important. Losses will happen but control their effect. Two points on $rzlt that
$RZLT Ersodetug to treat hypoglycemia caused by congenital hyperinsulinism (HI) or tumor HI. Human mAb that allosterically binds to insulin receptor to counteract excess signaling. Allows glucose to be in healthy range. FDA is aligned that ongoing Ph3'a sunRIZE
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How cool to see tamil on the slide here!
Proud to sponsor the 2025 Nature Conferences "Cracking the Code: Nucleic Acid Medicines Coming of Age" with @ionis_pharma and @harvardstemcell. Our SVP Mano Manoharan delivered a keynote on chemistry's role in RNA therapeutics. Thank you for the scientific exchange!
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The art of saying nothing in lots of words
Howard Marks on AI: "Since no one can say definitively whether this is a bubble, I'd advise that no one should go all-in without acknowledging that they face the risk of ruin if things go badly. But by the same token, no one should stay all-out & risk missing out on one of the
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$RZLT I like the science, and my back of the napkin math was wrong on post-ph3 readout price action. We haven't had ph3 readout yet and stock up 20%
$RZLT Ersodetug to treat hypoglycemia caused by congenital hyperinsulinism (HI) or tumor HI. Human mAb that allosterically binds to insulin receptor to counteract excess signaling. Allows glucose to be in healthy range. FDA is aligned that ongoing Ph3'a sunRIZE
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@zhaoweiasu @medstudentinvst Part of it is of course the macro environment and bull market of biotech ongoing. I can see the fulc reaction to interim data being flt to down a bit if the macro picture was tilted to a high interest rate bear market negative xbi sentiment
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@zhaoweiasu @medstudentinvst - $FULC built a position around 20 mg cohort and oral once daily PRC2i elevating HbF to a level that would meaningfully drop VOC burden for patients with SCD that was not controlled by HU or other drugs. Gene therapy is the future but that future will take time to be realized and
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First year/second year med school student given clinical case for discussion --> clearly fed into openevidence --> asks for it to be spit into format required --> copy/paste --> read off diagnostic reasoning and management to me --> how do I know? every student says the same
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Two different therapies that drug the same pathway at different points are advancing to registrational trials in the same disease, setting, and line of therapy at roughly the same time. $RVMD RASolute 303, a Ph3 study of daraxonrasib (pan-KRASi) + chemo (GnP) compared to GnP
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Post-gene therapy care! Integrated medical follow-up with mental health resources/counseling Opportunity for telehealth company focused specifically on this to emerge
𝐀𝐒𝐇 𝟐𝟎𝟐𝟓: @olagherej, whose life was changed after he participated in a clinical trial for a CRISPR based gene therapy for sickle cell disease, is attending his first ASH. Here's his message for the industry.
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